<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sarath Lal P S</style></author><author><style face="normal" font="default" size="100%">Thirumal M</style></author><author><style face="normal" font="default" size="100%">Ajith Babu T K</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical and Pharmacological Studies of Different Extracts of Stem Bark and Leaf of Flueggea leucopyrus Willd.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Extraction</style></keyword><keyword><style  face="normal" font="default" size="100%">Flueggea leucopyrus</style></keyword><keyword><style  face="normal" font="default" size="100%">In vitro anti-inflammatory activity</style></keyword><keyword><style  face="normal" font="default" size="100%">In vitro antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical evaluation</style></keyword><keyword><style  face="normal" font="default" size="100%">Spectral evaluation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1281-1289</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Traditional medicinal plants are generally extracted and evaluated to identify potential sources of effective drugs. Objective: The present study aimed to conduct the phytochemical and pharmacological evaluation of stem bark and leaf extracts of &lt;em&gt;Flueggea leucopyrus&lt;/em&gt;. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The collected plant material was dried, powdered, and extracted separately by soxhlation with different solvents viz., petroleum ether, n-hexane, chloroform, acetone, methanol, and water. All the extracts were subjected to phytochemical evaluation. Alkaloids were extracted and characterized from the powdered sample of leaf and bark. &lt;em&gt;In vitro&lt;/em&gt; antioxidant activity of the extracts was evaluated by DPPH (2, 2-diphenyl-1-picrylhydrazyl) and nitric oxide radical scavenging assay and anti-inflammatory activity by inhibition of protein denaturation and Human red blood cell (HRBC) membrane stabilization method. &lt;strong&gt;Results: &lt;/strong&gt;Extracts were found to be either semisolid or solid with different tints of green or brown colour. The preliminary phytochemical evaluation found alkaloids, glycoside, phenolic compounds, flavonoids, carbohydrates, sterol, and saponin. On spectral evaluation, the presence of an alkaloid, Securinol-A was found in a fraction extracted from the bark. In the &lt;em&gt;in vitro&lt;/em&gt; antioxidant and anti-inflammatory activity the tested samples showed a concentration-dependent rise of activity, particularly, the isolated fraction and acetone extract of stem bark revealed a significant activity. &lt;strong&gt;Conclusion:&lt;/strong&gt; Alkaloids, flavonoids, sterols, and saponins identified in these extracts may be responsible for these biological activities. Hopefully, our&lt;em&gt; in vitro&lt;/em&gt; and in &lt;em&gt;vivo &lt;/em&gt;evaluations&lt;em&gt; &lt;/em&gt;and compound-level studies in the future will reveal significant data for the development of clinically useful chemotherapeutic agents.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1281</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sarath Lal P S&lt;sup&gt;1&lt;/sup&gt;, Thirumal M&lt;sup&gt;2*&lt;/sup&gt;, Ajith Babu T K&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar, Department of Pharmacognosy, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu District-603203, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Associate Professor, Department of Pharmacognosy, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Chengalpattu District-603203, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Professor &amp;amp; Principal, Malik Deenar College of Pharmacy, Seethangoli, Kasaragod, Kerala, INDIA.&lt;/p&gt;
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