<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pallab Kar</style></author><author><style face="normal" font="default" size="100%">Ayodeji O. Oriola</style></author><author><style face="normal" font="default" size="100%">Adebola O. Oyedeji</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Natural Flavonoid Glycoside-Based Zinc Oxide Nanoparticles: Compound Isolation, Nanoparticle Green Synthesis, Characterization, and in vitro Antioxidant, Anti-hyperglycaemic and Anti-inflammatory Effects</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">antihyperglycaemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Green synthesis</style></keyword><keyword><style  face="normal" font="default" size="100%">natural flavonoid glycosides</style></keyword><keyword><style  face="normal" font="default" size="100%">ZnO Nanoparticles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">531-541</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Recent advances in effective and efficient drug delivery have favoured the biological applications of phytochemical-based metal oxide nanoparticles (NPs). Objective: This study, therefore, utilized a flavonoid glycoside, Myricitrin (MY), isolated from &lt;em&gt;Eugenia uniflora &lt;/em&gt;as a biogenic substance for the synthesis of zinc oxide nanoparticles (ZnONPs) and evaluated the antioxidant, anti-hyperglycaemic, and anti-inflammatory potentials. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Flavonoid glycoside was isolated from the leaf of &lt;em&gt;E. uniflora&lt;/em&gt; following standard phytochemical techniques for extraction, solvent-partitioning, column chromatography, and thin-layer chromatography. The phytocompound was characterized by NMR and HRESI-MS methods. Zinc oxide NPs were green synthesized using the isolated flavonoid glycoside. The biogenic ZnONPs were characterized using UV-Vis, FESEM, EDX, and XRD techniques. The biological potential of the MY-ZnONPs was based on in vitro analysis. Nitric oxide (NO), H2O2, OH, and O2 - antioxidant methods were used. The anti-hyperglycaemic effect was based on α-amylase and α-glucosidase enzyme inhibition, while the egg albumin denaturation (EAD) method was used to determine the antiinflammatory effect. &lt;strong&gt;Results:&lt;/strong&gt; Flavonoid glycoside was isolated and characterized as myricitrin from &lt;em&gt;E. uniflora&lt;/em&gt;. The MY-ZnONPs were green synthesized as a greyish powder. The UV-Vis absorption peaks at 387 and 415 nm match the characteristic peaks for ZnONPs. The FESEM revealed petal-, irregular-, and spindle-shaped NPs of 30-80 nm size, which tend to agglomerate in clusters and bundles. The EDX analysis showed the elemental weight percentage of Zn and O to be 79.83% and 18.51%, respectively, indicating the successful formation of ZnO nanoparticles. The X-ray diffractogram showed the crystallinity of the NPs at 29.23⁰, 36.25⁰, 51.50⁰, 63.67⁰, 72.06⁰, and 78.90⁰. At 100 μg/mL, the NPs demonstrated a comparable 68% inhibition of O&lt;sub&gt;2&lt;/sub&gt; - to Quercetin, the standard antioxidant. They inhibited EAD in a dose-de pendent manner, having ≥75% inhibition at 200 μg/mL. Finally, they exhibited notable anti-hyperglycaemic properties against α-amylase and α-glucosidase with IC&lt;sub&gt;50&lt;/sub&gt; of 89.24±0.63 and 105.95±0.05 μg/mL, respectively. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study has shown MY-ZnONPs as a flavonoid glycoside-based metal oxide nanoparticle with notable antioxidant, anti-diabetic, and anti-inflammatory activities.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">531</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Pallab Kar&lt;sup&gt;1,*&lt;/sup&gt;, Ayodeji O. Oriola&lt;sup&gt;2,*&lt;/sup&gt;, Adebola O. Oyedeji&lt;sup&gt;1,2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;African Medicinal Flora and Fauna Research Niche Area, Walter Sisulu University Nelson Mandela Drive, P/Bag X1, Mthatha 5117, SOUTH AFRICA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemical and Physical Sciences, Walter Sisulu University, Nelson Mandela Drive, P/ Bag X1, Mthatha 5117, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pallab Kar</style></author><author><style face="normal" font="default" size="100%">Ayodeji O. Oriola</style></author><author><style face="normal" font="default" size="100%">Adebola O. Oyedeji</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synthesis and Characterization of Biogenic Zinc Oxide Nanoparticles Using Eugenia uniflora Extract and its Anticancer Potential</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Eugenia uniflora</style></keyword><keyword><style  face="normal" font="default" size="100%">Green synthesis</style></keyword><keyword><style  face="normal" font="default" size="100%">ZnO Nanoparticles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">506-510</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Green synthesized nanoparticles have continued to be an important bioresource, exhibiting targeted delivery to diseases’ active sites with considerable eco-friendliness and effectiveness. &lt;strong&gt;Objective:&lt;/strong&gt; In this study, the medicinally useful Eugenia uniflora L. through green synthesis with zinc oxide nanoparticles (ZnONPs), was potentiated for its anticancer activity. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The leaf aqueous extract of E. uniflora (EU) was biosynthesized with zinc acetate dihydrate precursor to develop EU-ZnONPs. Characterization was based on field emission scanning electron microscopy (FESEM), high-resolution transmission electron microscopy (HRTEM), ultraviolet-visible (UV-Vis) spectroscopy, and energy-dispersive X-ray (EDX) spectroscopy. The anticancer potential of EU-ZnONPs was based on MTT-based cytotoxicity (CC50) against human cancerous (HepG2 and ACHN) cell lines. &lt;strong&gt;Results:&lt;/strong&gt; The FESEM revealed spherical-to-cubical shaped EU-ZnONPs with 40 and 80 nm average size ranges. Further microscopic evaluation by HRTEM showed that the bulk of the nanoparticles (NPs) are spherical, ranging from 5–30 nm in size. The UV-Vis absorption peak at 387 nm agreed with the characteristic 300-400 nm peak range of biogenic ZnONPs. The presence of Zn and O at elemental weight percentages of 73.55 and 23.05% confirmed the successful green synthesis of the Eu-ZnONPs. At 48 h post-treatment, the cytotoxicity against HepG2 and ACHN cancer cell lines was concentration-dependent, with CC50 values of 54.21 ± 0.06 μg/mL and 33.36 ± 2.25 μg/mL, respectively. &lt;strong&gt;Conclusion: &lt;/strong&gt;This study has shown that EUZnONPs possess notable cytotoxicity against HepG2 and ACHN cancer cells, thus suggesting E. uniflora extract-based ZnONPs as a promising anticancer bioresource.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">506</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Pallab Kar&lt;sup&gt;1*&lt;/sup&gt;, Ayodeji O. Oriola&lt;sup&gt;2*&lt;/sup&gt;, Adebola O. Oyedeji&lt;sup&gt;1,2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;African Medicinal Flora and Fauna Research Niche Area, Walter Sisulu University, Nelson Mandela Drive, P/Bag X1, Mthatha 5117, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemical and Physical Sciences, Walter Sisulu University, Nelson Mandela Drive, P/ Bag X1, Mthatha 5117, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ayodeji Oluwabunmi Oriola</style></author><author><style face="normal" font="default" size="100%">Pallab Kar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Zinc Oxide Nanoparticle Green Synthesis Using Black Cumin Seed Aqueous Extract: Its Characterization and in vitro Anti- Hyperglycaemic Properties</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-Hyperglycaemia</style></keyword><keyword><style  face="normal" font="default" size="100%">Black cumin</style></keyword><keyword><style  face="normal" font="default" size="100%">ZnO Nanoparticles</style></keyword><keyword><style  face="normal" font="default" size="100%">α-amylase</style></keyword><keyword><style  face="normal" font="default" size="100%">α-glucosidase</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">434-437</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; α-Amylase and α-glucosidase are carbohydrate metabolizing enzymes that are known to be involved in postprandial hyperglycaemia in diabetic patients. &lt;strong&gt;Objective:&lt;/strong&gt; In a bid to source potent inhibitors of these enzymes, the study synthesized zinc oxide nanoparticles and evaluated the in vitro anti-hyperglycaemic activity.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; The seed aqueous extract of black Cumin (BC) was used as a capping and/or reducing agent to synthesize ZnO NPs from zinc acetate precursor. The BC-ZnONPs were characterized by microscopy (FESEM and HRTEM) and spectroscopy (UV-Vis and EDX) methods. &lt;em&gt;In vitro &lt;/em&gt;anti-hyperglycaemic evaluation was based on α-amylase and α-glucosidase inhibition assays. &lt;strong&gt;Results:&lt;/strong&gt; The BC-ZnONPs showed a spherical-to-cubical shape with a 10-50 nm size range. The UV-Vis absorption peaks at 387 and 415 nm suggest the formation of biogenic ZnO NPs. The EDX spectrum revealed 68.92% and 27.49% weight compositions of Zn and O, respectively, to further substantiate ZnO nanoparticle synthesis. The BC-ZnONPs showed notable anti-hyperglycaemic properties with IC&lt;sub&gt;50&lt;/sub&gt; of 87.72±5.13 and 124.21±15.20 μg/mL against α-amylase and α-glucosidase, respectively.&lt;strong&gt; Conclusion: &lt;/strong&gt;Black Cumin seed extract was a useful biogenic material for synthesizing ZnO NPs. The BCZnONPs showed promising anti-hyperglycaemic properties based on the notable inhibitory activities against α-amylase and α-glucosidase enzymes. Future work may include evaluating the synergistic effects of black Cumin metabolites and ZnONPs, as well as determining the in vivo toxicity profile for safety considerations.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">434</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ayodeji Oluwabunmi Oriola&lt;sup&gt;1*&lt;/sup&gt;, Pallab Kar&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemical and Physical Sciences, Walter Sisulu University, Nelson Mandela Drive, P/ Bag X1, Mthatha 5117, SOUTH AFRICA&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;African Medicinal Flora and Fauna Research Niche Area, Walter Sisulu University, Nelson Mandela Drive, P/Bag X1, Mthatha 5117, SOUTH AFRICA&lt;/p&gt;
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