<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rattazart Denchai</style></author><author><style face="normal" font="default" size="100%">Somsak Nualkaew</style></author><author><style face="normal" font="default" size="100%">Pornpun Laovachirasuwan</style></author><author><style face="normal" font="default" size="100%">Nopphawan Pornsiri</style></author><author><style face="normal" font="default" size="100%">Chonlada Judprakop</style></author><author><style face="normal" font="default" size="100%">Surapong Rattana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-inflammatory Activity, Toxicity Assessment and GC-MS Chemical Profiling of Cha-Nu-Ruk Traditional Thai Herbal Poultice for Knee Pain Management</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Herbal poultice</style></keyword><keyword><style  face="normal" font="default" size="100%">Knee pain</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Thai traditional medicine</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2026</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2026</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">18</style></volume><pages><style face="normal" font="default" size="100%">31-35</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Thai Traditional herbal medicine employs multi-herb formulations for managing inflammatory conditions. This study investigates the anti-inflammatory properties, cytotoxicity, and chemical composition of Cha-Nu-Ruk, an eight-herb traditional poultice formulation for knee pain. &lt;strong&gt;Methods:&lt;/strong&gt; Eight medicinal plants (&lt;em&gt;Tiliacora triandra, Thunbergia laurifolia, Azadirachta indica, Clinacanthus nutans, Pandanus amaryllifolius, Justicia gendarussa, Sida acuta,&lt;/em&gt; and &lt;em&gt;Zingiber cassumunar&lt;/em&gt;) were extracted with 70% ethanol. Anti-inflammatory activity was evaluated through nitric oxide inhibition assay using Jurkat cells. Cytotoxicity was assessed via MTT assay. Chemical profiling employed GC-MS analysis. &lt;strong&gt;Results: &lt;/strong&gt;Individual plant extracts demonstrated variable anti-inflammatory activity (NO inhibition: 28.52-73.80%) with &lt;em&gt;Clinacanthus nutans &lt;/em&gt;showing highest potency. The combined eight-herb formulation yielded 11.82±0.41% extraction efficiency with 26.2% NO inhibition. GC-MS analysis identified 21 compounds, with DMPBD (19.13% relative abundance) and β-sitosterol (1.13%). Cytotoxicity evaluation revealed acceptable safety profiles (&amp;gt;80% cell viability) for most extracts. &lt;strong&gt;Conclusions:&lt;/strong&gt; While individual herbs showed promising anti-inflammatory potential, the traditional eight-herb combination did not demonstrate synergistic enhancement. Chemical standardization revealed significant batch-to-batch variability, highlighting the need for optimized formulation ratios and quality control protocols.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">31</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rattazart Denchai&lt;sup&gt;1&lt;/sup&gt;, Somsak Nualkaew&lt;sup&gt;2&lt;/sup&gt;, Pornpun Laovachirasuwan&lt;sup&gt;2&lt;/sup&gt;, Nopphawan Pornsiri&lt;sup&gt;3&lt;/sup&gt;, Chonlada Judprakop4, Surapong Rattana&lt;sup&gt;5*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Thai Traditional Medicine, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmaceutical Chemistry and Natural Product Research Unit, Faculty of Pharmacy, Mahasarakham University, Maha Sarakham, 44150, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Applied Thai Traditional Medicine, Faculty of Science and Technology, Phanakhon Rajabhat University, Bangkok, 10220, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Pharmacy, Nakhonratchasima College, Nakhon Ratchasima, 30000, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Division of Science, Faculty of Education, Nakhon Phanom University, Nakhon Phanom, 48000, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">On-Anong Somsap</style></author><author><style face="normal" font="default" size="100%">Wasinee Poonsawat</style></author><author><style face="normal" font="default" size="100%">Ameena Benchamana</style></author><author><style face="normal" font="default" size="100%">Anussara Kamnate</style></author><author><style face="normal" font="default" size="100%">Gornganok Piboonpol</style></author><author><style face="normal" font="default" size="100%">Wanita Pantong</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-Tyrosinase, Anti-Inflammatory, and Cytotoxic Activity of Si Boo Gan Tang Rice and Rice Bran Extracts</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-tyrosinase</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">HaCaT cell</style></keyword><keyword><style  face="normal" font="default" size="100%">Si Boo Gan Tang Rice</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">22-27</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Si Boo Gan Tang is a widely cultivated variety of rice in the Tak Bai district of Narathiwat province, located in the southern region of Thailand. This study aimed to evaluate the biological properties of Si Boo Gan Tang rice and rice bran extracts, focusing on their anti-tyrosinase activity, anti-inflammatory activity, and cytotoxicity. The anti-tyrosinase assay revealed that the aqueous extract of rice (RW) significantly inhibited tyrosinase activity by 41.47%. Similarly, the ethanolic extract of rice (RE) exhibited anti-tyrosinase activity at 35.34%. The aqueous (RBW) and ethanolic (RBE) extracts of rice bran showed anti-tyrosinase activity with percentages of 19.26% and 29.08%, respectively. The anti-inflammatory experiment, conducted using RAW 264.7 cells, demonstrated that all extracts (RW, RBW, RE, and RBE) from rice and rice bran exhibited anti-inflammatory properties by reducing the release of nitric oxide (NO) from lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The extracts had IC&lt;sub&gt;50&lt;/sub&gt; values of over 400 μg/ml and CC&lt;sub&gt;50&lt;/sub&gt; values over 400 μg/ml. Cytotoxicity was assessed using the MTT assay on HaCaT cells. The findings indicated that the IC&lt;sub&gt;50&lt;/sub&gt; values for both aqueous and ethanolic extracts of rice and rice bran were greater than 800 μg/ml.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">22</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;On-Anong Somsap&lt;sup&gt;1*&lt;/sup&gt;, Wasinee Poonsawat&lt;sup&gt;2&lt;/sup&gt;, Ameena Benchamana&lt;sup&gt;3&lt;/sup&gt;, Anussara Kamnate&lt;sup&gt;4&lt;/sup&gt;, Gornganok Piboonpol&lt;sup&gt;5&lt;/sup&gt;, Wanita Pantong&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biochemistry, Faculty of Medicine, Princess of Naradhiwas University, Narathiwat 96000, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;The Center for Scientific and Technological Equipment, Walailak University, NaKhon Si Thammarat 80160, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Physiology, Faculty of Medicine, Princess of Naradhiwas University, Narathiwat 96000, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Anatomy, Faculty of Medicine, Princess of Naradhiwas University, Narathiwat 96000, THAILAND.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Pharmacology, Faculty of Medicine, Princess of Naradhiwas University, Narathiwat 96000, THAILAND.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Omar Naseem Alzrigat</style></author><author><style face="normal" font="default" size="100%">Yazeed Nabeel Al-Qusous</style></author><author><style face="normal" font="default" size="100%">Dema Maher Masadeh</style></author><author><style face="normal" font="default" size="100%">Madleen Nabeel Al-Qusous</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Discover How Ashwagandha May Impact Health: A Comprehensive Review</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticancer dosage</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Ashwagandha</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Withania somnifera</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">394-398</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Withania somnifera (Ashwagandha) is a medicinal herb that has been commonly utilized in traditional medicine for millennia, particularly in Ayurvedic practices. The root of the plant is pharmacologically active and has been used for its aphrodisiac, diuretic, anti-helminthic, narcotic, tonic, and stimulant properties. Additionally, other parts of ashwagandha, including the leaves, shoots, seeds, and berries, contribute to its health-promoting effects and the potential for improving longevity. This plant is composed of many bioactive compounds which exhibit a myriad of health-enhancing properties. Contemporary research has focused on the multifaceted bioactivities of ashwagandha, revealing promising impacts such as anticancer, antioxidant, and anti-inflammatory activities, among other therapeutic applications. This review was planned to find the most recent findings, providing an examination of the active constituents of ashwagandha, their biological activities, and a critical assessment of any associated safety concerns and potential toxicity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">394</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Omar Naseem Alzrigat&lt;sup&gt;1&lt;/sup&gt;, Yazeed Nabeel Al-Qusous&lt;sup&gt;2&lt;/sup&gt;, Dema Maher Masadeh&lt;sup&gt;1&lt;/sup&gt;, Madleen Nabeel Al- Qusous&lt;sup&gt;3*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;King Hussein Medical Center, Amman 11855, JORDAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine, Mutah University, Al-Karak 61710, JORDAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Clinical Pharmacy, Faculty of Pharmacy, Mutah University, Al-Karak 61710, JORDAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Aasia Kanwal</style></author><author><style face="normal" font="default" size="100%">Muhammad Hamdi Mahmood</style></author><author><style face="normal" font="default" size="100%">Mahad Butt</style></author><author><style face="normal" font="default" size="100%">Hidayat Ur Rahman</style></author><author><style face="normal" font="default" size="100%">Norhida Ramli</style></author><author><style face="normal" font="default" size="100%">Saiful Bahri Talip</style></author><author><style face="normal" font="default" size="100%">Showkat Ahmad Bhawani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effect of Components of Gamma Oryzanol on Toll-Like Receptor 4: Receptor Structure-Based Pharmacophore, Hit Identification, and In Silico Evidence</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Gamma oryzanol</style></keyword><keyword><style  face="normal" font="default" size="100%">Infertility</style></keyword><keyword><style  face="normal" font="default" size="100%">Polycystic ovarian syndrome</style></keyword><keyword><style  face="normal" font="default" size="100%">TLR4 antagonist</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">329-335</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Polycystic ovarian syndrome is a leading cause of female infertility. Inflammation has a central role in infertility. Persistent activation of Toll-like receptor 4 contributes to inflammation in PCOS. Gamma-oryzanol consists of esters of ferulic acid combined with phytosterols and triterpene alcohol derivatives of rice bran oil, and is known to have anti-inflammatory effects. However, the structural interaction of different gamma-oryzanol compounds with TLR4 remains unknown. &lt;strong&gt;Objectives: &lt;/strong&gt;The study aimed to investigate gamma oryzanol compounds as hit compounds and inhibitors of Toll-like receptor 4 by developing a pharmacophore model through a receptor structure-based approach coupled with molecular docking studies with the Molecular Operating Environment (MOE) software. &lt;strong&gt;Methods: &lt;/strong&gt;A structure-based pharmacophore model was generated from the co-crystalized structure of the TLR4– MD2 complex. Gamma-oryzanol derivatives were evaluated against the constructed pharmacophore model to identify potential hit compounds. The potential hit compounds that satisfied essential pharmacophoric features were subjected to molecular docking with TLR4. &lt;strong&gt;Results:&lt;/strong&gt; The pharmacophore consisted of three characteristics: a hydrogen bond donor, a hydrogen bond acceptor, and a hydrophobic. Cycloartenyl ferulate, 24-methylenecycloartenyl ferulate, Campesteryl ferulate, and β-sitosteryl ferulate were found to be the hit compounds against the generated pharmacophore. The docking experiment showed that Cycloartenyl ferulate had the most potent binding interaction with TLR4 (7.9933), followed by 24-methylenecycloartenyl ferulate (-7.8580), Campesteryl ferulate (-6.1675), and β-sitosteryl ferulate (-5.9673). &lt;strong&gt;Conclusion: &lt;/strong&gt;The present pharmacophore modeling and docking findings predict that gammaoryzanol may bind with the TLR4 ligand binding domain, providing structural insights into their therapeutic potential role as a modulator of the TLR4-mediated inflammatory pathway. These findings provide a theoretical foundation for future in vitro and in vivo validation studies aimed at elucidating the mechanistic basis of gamma-oryzanol’s anti-inflammatory activity in PCOS.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">329</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Aasia Kanwal&lt;sup&gt;1*&lt;/sup&gt;, Muhammad Hamdi Mahmood&lt;sup&gt;1&lt;/sup&gt;, Mahad Butt&lt;sup&gt;2&lt;/sup&gt;, Hidayat Ur Rahman&lt;sup&gt;1&lt;/sup&gt;, Norhida Ramli&lt;sup&gt;1&lt;/sup&gt;, Saiful Bahri Talip&lt;sup&gt;1&lt;/sup&gt;, Showkat Ahmad Bhawani&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine &amp;amp; Health Sciences, Universiti Malaysia Sarawak, 94300 Kota Samarahan, MALAYSIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Medicine, Allama Iqbal Medical College, 54550 Lahore, PAKISTAN. 3Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, 94300 Kota Samarahan, MALAYSIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ica Yulianti Pulungan</style></author><author><style face="normal" font="default" size="100%">Ermi Girsang</style></author><author><style face="normal" font="default" size="100%">Ermi Girsang</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Protective Role of Centella asiatica Extract Against Carbon Tetrachloride–Induced Hepatic Damage: A Biochemical and Ultrasonographic Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Centella asiatica</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytokines</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Ultrasonography</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">760-769</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aimed to evaluate the hepatoprotective activity of &lt;em&gt;Centella asiatica&lt;/em&gt; extract on Wistar rats induced with carbon tetrachloride (CCl&lt;sub&gt;₄&lt;/sub&gt;). The extract is known to contain active compounds such as flavonoids, phenolics, and triterpenoids, which contribute to its antioxidant and anti-inflammatory effects. The total phenolic and flavonoid contents were 70.31 mg GAE/g and 13.49 mg QE/g, respectively, with very strong antioxidant activity (IC&lt;sub&gt;₅₀&lt;/sub&gt; = 48.45 ppm). Evaluation through ultrasonography and histopathology revealed structural improvement in the liver of treated groups, particularly at doses of 200 and 300 mg/ kgBW, marked by reduced abnormal echogenicity and improved liver parenchyma, along with a decrease in histopathological score from 2 to 1. The administration of the extract also significantly reduced proinflammatory cytokines TNF-α and IL-6 (P≤0.05), as well as CRP levels, indicating strong anti-inflammatory potential. In addition, liver function showed meaningful recovery, with the highest albumin level recorded at 200 mg/kgBW (3.00 ± 0.52 g/dL), and a significant reduction in bilirubin level at 300 mg/kgBW to 0.102 ± 0.040 mg/dL. Significant decreases were also observed in SGOT and SGPT enzyme levels in the treatment groups, especially at 300 mg/kgBW, indicating protection of hepatocyte integrity. In conclusion, this study demonstrated that Centella asiatica extract possesses hepatoprotective effects through antiinflammatory, antioxidant, and liver function-restorative mechanisms. These findings support the potential development of pegagan as a phytopharmaceutical agent for adjunct therapy in liver disorders and highlight the need for further studies on its active compounds and long-term safety.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">760</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ica Yulianti Pulungan&lt;sup&gt;1*&lt;/sup&gt;, Ermi Girsang&lt;sup&gt;2&lt;/sup&gt;, Yolanda Eliza Putri Lubis&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Dijeng Euginiah Rampana</style></author><author><style face="normal" font="default" size="100%">Pakiso Moses Makhoahle</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A Review: Searsia genus and Its Potential Anti-Cancer Properties</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemistry</style></keyword><keyword><style  face="normal" font="default" size="100%">Searsia genus</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">117-120</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The &lt;em&gt;Searsia genus&lt;/em&gt;, belonging to the &lt;em&gt;Anacardiaceae&lt;/em&gt; family, comprises small trees and evergreen shrubs primarily found in Southern Africa, with some species extending to East Africa and the Mediterranean. While these species are well-known for their ecological roles in stabilizing soils and providing habitat for wildlife, they also possess significant medicinal value, particularly in traditional African medicine. Searsia plants are rich in bioactive compounds such as flavonoids, phenolic acids, and tannins, which exhibit potent anti-inflammatory, antibacterial, antioxidant, and anticancer properties. This has drawn scientific interest, especially regarding their potential in cancer treatment. Notably, &lt;em&gt;Searsia chirindensis&lt;/em&gt; and other species have demonstrated cytotoxic effects against various cancer cell lines, attributed to compounds like gallic acid and other polyphenolics. This review delves into the phytochemical profiles of selected &lt;em&gt;Searsia species&lt;/em&gt;, exploring their medicinal properties with a particular focus on their anticancer activities. The anti-inflammatory properties of these plants, coupled with their antioxidant activities, suggest a promising role in cancer prevention and treatment, although further research is necessary to confirm these benefits in clinical settings.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">117</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Dijeng Euginiah Rampana*, Pakiso Moses Makhoahle&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Health Sciences, Faculty of Health Sciences, Central University of Technology, Bloemfontein, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ayodeji O. Oriola</style></author><author><style face="normal" font="default" size="100%">Pallab Kar</style></author><author><style face="normal" font="default" size="100%">Adebola O. Oyedeji</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Synthesis and Characterization of Biogenic Silver Nanoparticles using Medicinally important Nigella sativa L. (black Cumin) and their Antioxidant, Anti‑inflammatory, and DNA Cleavage Potentials</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">DNA cleavage</style></keyword><keyword><style  face="normal" font="default" size="100%">Nigella sativa</style></keyword><keyword><style  face="normal" font="default" size="100%">Silver nanoparticles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">282-288</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The application of nanotechnology in herbal medicine offers promising prospects for drug delivery by enabling targeted, controlled, and efficient delivery of medicinal ingredients, potentially minimizing side effects and improving treatment outcomes. Nigella sativa L. (black Cumin) seed infusions are useful in Asian and African ethnomedicines in remedying stress and inflammatory-related ailments. &lt;strong&gt;Objective: &lt;/strong&gt;On this premise, black Cumin-based silver nanoparticles (BC-Ag NP) were developed and evaluated for their biological potential. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Silver nanoparticles (AgNPs) were green synthesized using the seed aqueous extract of black cumin (BC). The BC-AgNPs were characterized using scanning electron microscopy (SEM), field emission scanning electron microscopy (FESEM), highresolution transmission electron microscopy analysis (HRTEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD). The biological potential of the NPs was based on NO, H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt;, •OH, and O&lt;sub&gt;2&lt;/sub&gt; •– radical scavenging antioxidant, egg albumin denaturation (anti-inflammatory), and DNA cleavage assay methods.&lt;strong&gt; Results: &lt;/strong&gt;The SEM and FESEM revealed spherical-to-cubical-shaped ultrafine BC-Ag NPs with a size of less than 100 nm. The HR-TEM micrograph confirmed each NP to be spherical in shape and within the 10-50 nm range. The X-ray diffractogram showed the crystallinity of the NPs with a sharp peak at 38.12° [reflection index (111)] at an average size of 47 nm. The transformation of metallic silver into elemental silver was validated by EDX analysis, with 97.58% elemental Ag at ~3 keV acute curve. The BC-Ag NPs showed dose-dependent antioxidant activity, with IC50 of 87.56 ± 1.54 and 110.5 ± 2.27 μg/mL against H&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;2&lt;/sub&gt; and O&lt;sub&gt;2&lt;/sub&gt; ._ free radicals, respectively. The anti-inflammatory activity of the NPs was one-third the potency of Diclofenac sodium (standard drug) at IC&lt;sub&gt;50&lt;/sub&gt; of 103.44 ± 5.35 μg/mL. Finally, the BC-Ag NPs acted as chemical nucleases to cleave DNA at a 20 mg/mL concentration for 120 minutes.&lt;strong&gt; Conclusion: &lt;/strong&gt;This study has shown that AgNPs biosynthesized with black Cumin seed extract possess notable antioxidant, anti-inflammatory, and DNA cleavage properties and, thus, may be a useful nanomaterial for efficient pharmaceutical delivery.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">282</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ayodeji O. Oriola&lt;sup&gt;1,*&lt;/sup&gt;, Pallab Kar&lt;sup&gt;2,*&lt;/sup&gt;, Adebola O. Oyedeji&lt;sup&gt;1,2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Chemical and Physical Sciences, Walter Sisulu University, Nelson Mandela Drive, P/ Bag X1, Mthatha 5117, SOUTH AFRICA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;African Medicinal Flora and Fauna Research Niche Area, Walter Sisulu University Nelson Mandela Drive, P/Bag X1, Mthatha 5117, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Inda Kania Meilani</style></author><author><style face="normal" font="default" size="100%">Ermi Girsang</style></author><author><style face="normal" font="default" size="100%">Yolanda Eliza Putri Lubis</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ultrasonographic and Biochemical Evaluation of the Hepatoprotective Effect of Cinnamomum burmannii Bark Extract in Carbon Tetrachloride–Induced Liver Injury</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cinnamon</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytokine</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2025</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2025</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">17</style></volume><pages><style face="normal" font="default" size="100%">751-759</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This study aimed to evaluate the hepatoprotective activity of ethanolic extract of cinnamon (&lt;em&gt;Cinnamomum burmannii&lt;/em&gt;) in male Wistar rats induced with carbon tetrachloride (CCl&lt;sub&gt;₄&lt;/sub&gt;). Cinnamon extract is known to contain bioactive compounds such as flavonoids and polyphenols, which play significant roles in antioxidant and anti-inflammatory mechanisms. Phytochemical analysis revealed that the extract contained total phenolic content of 71.55 mg GAE/g and flavonoid content of 0.41 mg QE/g, with a potent antioxidant activity indicated by an IC&lt;sub&gt;₅₀&lt;/sub&gt; value of 18.19 ppm. Administration of the extract for 28 days at a dose of 300 mg/kg body weight resulted in a significant reduction (P&amp;lt;0.05) in pro-inflammatory cytokines TNF-α, IL-6, and CRP levels compared to the negative control group. The 300 mg/kg dose showed the highest efficacy, with TNF-α levels approaching those of the normal group. Furthermore, liver function parameters improved, as evidenced by significant reductions in SGOT and SGPT enzyme levels, an increase in serum albumin (2.96 ± 0.52 g/dL), and a decrease in serum bilirubin to 0.102 ± 0.040 mg/dL. Ultrasonographic examination showed improved liver parenchymal homogeneity and a reduction in the number of nodules. Histopathological findings revealed a decrease in liver tissue damage score from moderate to mild. These findings suggest that &lt;em&gt;Cinnamomum burmannii&lt;/em&gt; extract has potential hepatoprotective effects through antiinflammatory, antioxidant, and hepatocellular recovery mechanisms. Therefore, this extract holds promise as a phytopharmaceutical candidate for complementary therapy in liver function disorders; however, further studies are required to isolate the active compounds and evaluate long-term toxicity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">751</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Inda Kania Meilani&lt;sup&gt;1*&lt;/sup&gt;, Ermi Girsang&lt;sup&gt;2&lt;/sup&gt;, Yolanda Eliza Putri Lubis&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Public Health and Preventive Medicine, Faculty of Medicine, Dentistry, and Health Science, Universitas Prima Indonesia, Universitas Prima Indonesia, Medan 20118, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elizabeth Bosede Aladejana</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Biological Properties of Polyherbal Formulations: A Review of their Antimicrobial, Anti-Inflammatory, Antioxidant, and Toxicological Activities</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antimicrobial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyherbal medicines</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicological properties.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">933-963</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The use of traditional and folklore systems of medicine has been an important part of healthcare worldwide, and polyherbal formulations, which are combinations of different herbs, are gaining recognition for their medicinal and therapeutic potential. These formulations can be optimized to have stronger therapeutic effects with lower toxicity. The aim of this study was to review research on the antimicrobial, antiinflammatory, antioxidant and toxicological properties of polyherbal formulations around the world, with a view to promoting their use and identifying areas where further research is needed. The author analyzed 99 articles published between 2010 and 2022, using scientific search engines such as Elsevier, BioMed Central, ScienceDirect, PubMed, and Scopus, to assess the use of polyherbal formulations in different countries. This article enlists some commercial and non-commercial polyherbal formulations all around the world with India leading in the number of publications on polyherbal formulations, followed by Nigeria, and Pakistan. The various pharmacological studies conducted have shown that polyherbal medicines possess antimicrobial, anti-inflammatory, antioxidant and toxicological properties, hence, validating their traditional use. However, further clinical work is required to fully understand the therapeutic potential of polyherbal formulations. The growing interest in the therapeutic use of non-toxic conventional medicinal plants as low-cost alternatives for disease prevention and treatment has made natural products valuable tools for creating new lead compounds and scaffolds. Plants will continue to play a pivotal role in the discovery of drugs for human diseases, and the development of potent cures derived from plants would represent significant progress in the treatment of diseases.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">933</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elizabeth Bosede Aladejana*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Electron Microscope Unit; Medicinal Plants for Economic Development Niche Area, Faculty of Science and Agriculture, University of Fort Hare, Private Bag X1314, Alice 5700, SOUTH AFRICA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sardar Hussain</style></author><author><style face="normal" font="default" size="100%">Komal KP</style></author><author><style face="normal" font="default" size="100%">Guruvayoorappan C</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Emilia Sonchifolia-A Critical and Comprehensive Review of its  Diverse Medicinal Potential and Future as Therapeutic</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-tumour</style></keyword><keyword><style  face="normal" font="default" size="100%">Emilia sonchifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plant</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1143-1149</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Emilia sonchifolia&lt;/em&gt; (L.) DC, it belongs to the family Asteraceae or Compositae, is conventionally used in ethnomedicine, and acquires various medicinal properties. This plant has been regarded as one of the widespread traditional vegetable salads in Malaysia, Bangladesh, and India. In addendum to its avail as a vegetable, the plant has been documented with several medicinal benefits in the extravagance of night blindness, epilepsy, malaria, asthma, burns, breast abscesses, and inflammatory diseases. On scrutinization of their pharmacological properties, it has been revealed that they possess numerous notable biological properties such as antimicrobial, analgesic, anti-inflammatory, antioxidant, hepatoprotective, antianxiety, and anticataract, as well as anticonvulsant activities. Concrete evidence suggests the presence of potential phytochemicals in this plant with a wide range of unknown applications. In this current review, we discuss the phytochemicals present in the plant &lt;em&gt;Emilia sonchifolia &lt;/em&gt;and emphasize the therapeutic and pharmacological activities reported so far concerning this plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1143</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sardar Hussain&lt;sup&gt;1&lt;/sup&gt; , Komal KP&lt;sup&gt;2&lt;/sup&gt; , Guruvayoorappan C&lt;sup&gt;3&lt;/sup&gt;,*&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Ph.D. Scholar, R&amp;amp;D Centre, Bharathiar University, Coimbatore 641 046, Tamil Nādu; Assistant Professor, Department of Biotechnology, Government Science College, Chitradurga 577 501, Karnataka, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Assistant Professor, Department of Biochemistry, Government Science College, Chitradurga 577 501, Karnataka, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Associate Professor, Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram 695 011, Kerala, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Bhuvaneshwari. J</style></author><author><style face="normal" font="default" size="100%">Thirumalai Vasan. P</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Bio-Evaluation, In-Vitro and In-Vivo Anti-Inflammatory Activity, Therapeutic Efficacy, and Genotoxicity of the Potentials of the Green Seaweed Valoniopsis Pachynema using Zebra Fish Larvae (Danio Rerio) as an Animal Model</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Bioactive compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS</style></keyword><keyword><style  face="normal" font="default" size="100%">Marine algae</style></keyword><keyword><style  face="normal" font="default" size="100%">V. pachynema</style></keyword><keyword><style  face="normal" font="default" size="100%">Zebra fish larvae drug toxicity.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">1037-1053</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Advancement in the medical sectors to treat regular diseases are increasing day-by-day. Yet, there is a considerable growth in the demand for the natural/herbal products as well due to their low level of side effects, cost efficiency and their multiple inhibition properties. Based on this, the present research works with an objective to examine the bioactive components, &lt;em&gt;in vitro&lt;/em&gt; anti-inflammatory and in vivo antiinflammatory behaviour of the green marine macro algae &lt;em&gt;Valoniopsis pachynema &lt;/em&gt;using zebra fish (Danio rerio) larvae as a skin inflammation model. In this study, the secondary metabolites are extracted using methanol solvent from the marine green seaweed, &lt;em&gt;V. pachynema&lt;/em&gt; using the Gas Chromatography-Mass Spectrometry (GC-MS) analysis and these are further evaluated for their anti-inflammatory effects. Further screening process is accomplished for the&lt;em&gt; in vitro &lt;/em&gt;anti-inflammatory activity by the albumin-denaturation inhibition. Results from concentration-dependent analysis is documented. The efficacy, therapeutic efficacy, and genotoxicity of the compound Valp at various concentrations are determined by recapitulating the pathophysiology of Skin inflammation in Zebrafish larvae. In evaluating the efficiency of the study, Valp at 1 pg, 10 pg, 100 pg are observed and progressed for the evaluation of therapeutic efficacy and genotoxicity. In the assessment of genotoxicity, the gene expression of mgmt gene is observed to be in control level at Valp 100 pg treated group confirming no genotoxicity. According to the results obtained, the green seaweed&lt;em&gt; V. pachynema&lt;/em&gt; can be potentially explored as an effectual anti-inflammatory agent for its bio-functionalities&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">1037</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Bhuvaneshwari. J&lt;sup&gt;1&lt;/sup&gt;, Thirumalai Vasan. P&lt;sup&gt;2,*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Research Scholar and adjunct faculty, Department of Biotechnology, Srimad Andavan College of Arts and Science (Autonomous), Affiliated to Bharathidasan University, Thiruvanaikovil, Tiruchirapalli, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Professor and Head, Department of Biotechnology, Srimad Andavan College of Arts and Science (Autonomous), Affiliated to Bharathidasan University, Thiruvanaikovil, Tiruchirapalli, Tamil Nadu, INDIA&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Min Rahminiwati</style></author><author><style face="normal" font="default" size="100%">Trivadila</style></author><author><style face="normal" font="default" size="100%">Dyah Iswantini</style></author><author><style face="normal" font="default" size="100%">Hiroshi Takemori</style></author><author><style face="normal" font="default" size="100%">Mamoru Koketsu</style></author><author><style face="normal" font="default" size="100%">Rut Novalia Rahmawati Sianipar</style></author><author><style face="normal" font="default" size="100%">Suminar Setiati Achmadi</style></author><author><style face="normal" font="default" size="100%">Ahmad Sjahriza</style></author><author><style face="normal" font="default" size="100%">Betty Marita Soebrata</style></author><author><style face="normal" font="default" size="100%">Armi Wulanawati</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Indonesian Medicinal Plants with Anti-inflammatory Properties and Potency as Chronic Obstructive Pulmonary Disease (COPD) Herbal Medicine</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Bioactive compounds</style></keyword><keyword><style  face="normal" font="default" size="100%">Biological activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chronic obstructive pulmonary disease</style></keyword><keyword><style  face="normal" font="default" size="100%">Indonesian medicinal plants</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2022</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">432-444</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Indonesia is a tropical country with mega-biodiversity. Several medicinal plants locally have been recognized for their anti-inflammatory properties and are traditionally used to help treat respiratory diseases. Chronic obstructive pulmonary disease (COPD) is one of the diseases known as the high cause of death globally, and one of the treatment efforts is by using anti-inflammatory drugs. In developing alternative remedies for COPD, this review summarizes the potential of Indonesian medicinal plants and their ingredients known to have an anti-inflammatory activity to develop alternative remedies for COPD. Primarily, we focus on the medicinal plants that have been scientifically proven to pose some biological activities, such as legetan warak (&lt;em&gt;Adenostemma lavenia&lt;/em&gt;), celery &lt;em&gt;(Apium graveolens&lt;/em&gt;),&lt;em&gt; pegagan&lt;/em&gt; (&lt;em&gt;Centella asiatica&lt;/em&gt;),&lt;em&gt; kenikir &lt;/em&gt;(&lt;em&gt;Cosmos caudatus&lt;/em&gt;), and &lt;em&gt;kersen (Muntingia calabura). &lt;/em&gt;This review is expected to provide more information about Indonesian medicinal plants and their potencies to be developed as COPD herbal medicine and, further, as a treatment to help patients suffering from coronavirus disease (COVID-19).&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><accession-num><style face="normal" font="default" size="100%">26</style></accession-num><section><style face="normal" font="default" size="100%">432</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Min Rahminiwati&lt;sup&gt;1,4,*&lt;/sup&gt;, Trivadila&lt;sup&gt;2,4&lt;/sup&gt;, Dyah Iswantini&lt;sup&gt;2,4&lt;/sup&gt;,*, Hiroshi Takemori&lt;sup&gt;3&lt;/sup&gt;, Mamoru Koketsu&lt;sup&gt;3&lt;/sup&gt;, Rut Novalia Rahmawati Sianipar&lt;sup&gt;2&lt;/sup&gt;, Suminar Setiati Achmadi&lt;sup&gt;2,4&lt;/sup&gt;, Ahmad Sjahriza&lt;sup&gt;2&lt;/sup&gt;, Betty Marita Soebrata&lt;sup&gt;2&lt;/sup&gt;, Armi Wulanawati&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Anatomy, Physiology, and Pharmacology, Faculty of Veterinary Medicine, IPB University, Bogor 16680, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University, Bogor 16680, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, JAPAN.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Tropical Biopharmaca Research Center, IPB University, Bogor 16128, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Afriwardi</style></author><author><style face="normal" font="default" size="100%">Rahmatul Nazmi</style></author><author><style face="normal" font="default" size="100%">Dwisari Dillasamola</style></author><author><style face="normal" font="default" size="100%">Elsa Badriyya</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-inflammatory Activity of Pegagan Embun (Hydrocotyle sibthorpioides Lam.) Plant Extract on Topical Application</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Exudate</style></keyword><keyword><style  face="normal" font="default" size="100%">Gel</style></keyword><keyword><style  face="normal" font="default" size="100%">Hydrocotyle sibthorpioides Lam.</style></keyword><keyword><style  face="normal" font="default" size="100%">Ketoprofen</style></keyword><keyword><style  face="normal" font="default" size="100%">Leukocytes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">411-417</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Pegagan embun (&lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam.) is traditionally known to have many benefits, including anti-inflammatory.&lt;strong&gt; Aims:&lt;/strong&gt; This study aimed to determine the activity of ethanol extract of Pegagan Embun as an anti-inflammatory using the granuloma pouch method. &lt;strong&gt;Methods:&lt;/strong&gt; This experiment used 25 male white mice and were divided into five groups, namely, the positive control group, &lt;em&gt;Hydrocotyle sibthorpioides &lt;/em&gt;Lam. extract group with concentration 0.5%; 1%; 2%, and the comparison group that given Kaltrofen® gel containing 2.5% ketoprofen. Experimental animals were given carrageenan 2% to induced the inflammation subcutaneously. The dosage form was given as much as 0.2 g topically for four days once a day. &lt;strong&gt;Results:&lt;/strong&gt; Based on the results of one-way ANOVA analysis and Duncan's test, there were significant differences in exudate volume and total leukocytes (p&amp;lt;0.05) in the positive control group, extract with concentration 0.5%, 1%, 2%, and the comparator. While the percentage of leukocyte cells showed that they were not significantly different (p&amp;gt;0.05), the number of neutrophil cells decreased. &lt;strong&gt;Conclusion:&lt;/strong&gt; From the overall data obtained, it can be concluded that the extract of &lt;em&gt;Hydrocotyle sibthorpioides&lt;/em&gt; Lam. at concentration 0.5 %; 1%; 2%, has an anti-inflammatory effect.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">411</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Afriwardi&lt;sup&gt;1,&lt;/sup&gt;*, Rahmatul Nazmi&lt;sup&gt;2&lt;/sup&gt;, Dwisari Dillasamola&lt;sup&gt;2&lt;/sup&gt;, Elsa Badriyya&lt;sup&gt;2&lt;/sup&gt;, Yufri Aldi&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Medicine, Andalas University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy, Andalas University, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Saleh A Almatroodi</style></author><author><style face="normal" font="default" size="100%">Ahmad Almatroudi</style></author><author><style face="normal" font="default" size="100%">Mohammed A Alsahli</style></author><author><style face="normal" font="default" size="100%">Arshad Husain Rahmani</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Fenugreek (Trigonella Foenum-Graecum) and its Active Compounds: A Review of its Effects on Human Health through Modulating Biological Activities</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-cancer activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-oxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Fenugreek</style></keyword><keyword><style  face="normal" font="default" size="100%">Health management</style></keyword><keyword><style  face="normal" font="default" size="100%">Trigonella foenum-graecum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">813-821</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Fenugreek seed are rich sources of various essential compounds and such components shows a significant role in the diseases cure and management through its anti-inflammatory, hepatoprotective, cardioprotective, neuroprotective, immunomodulatory, nephroprotective and anti-microbial activity. Moreover, fenugreek seed is a rich source of antioxidant and such potentiality inhibit the pathogenesis of diseases through free radical scavenging activity. Besides, fenugreek and its active compound shows role in tumour inhibition through modulating various genes activity including induction of apoptosis, tumour suppressor gene and inhibition of tumor necrosis factor. This review comprehensively summarizes the role of fenugreek seeds in health management through modulating various physiological and biochemical activities, along with special emphasis on &lt;em&gt;in vitro &lt;/em&gt;and&lt;em&gt; in vivo&lt;/em&gt; study.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">813</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Saleh A. Almatroodi&lt;sup&gt;1&lt;/sup&gt;, Ahmad Almatroudi&lt;sup&gt;1&lt;/sup&gt;, Mohammed A. Alsahli&lt;sup&gt;1&lt;/sup&gt;, Arshad Husain Rahmani&lt;sup&gt;1,&lt;/sup&gt;*&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Laboratories, College of Applied Medical Science, Buraydah 52571, Qassim University, SAUDI ARABIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Raden Joko Kuncoroningrat Susilo</style></author><author><style face="normal" font="default" size="100%">Dwi Winarni</style></author><author><style face="normal" font="default" size="100%">Saikhu Akhmad Husen</style></author><author><style face="normal" font="default" size="100%">Suhailah Hayaza</style></author><author><style face="normal" font="default" size="100%">Sri Puji Astuti Wahyuningsih</style></author><author><style face="normal" font="default" size="100%">Ruey-An Doong</style></author><author><style face="normal" font="default" size="100%">Win Darmanto</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Hepatoprotective Effect of Ganoderma applanatum Crude Polysaccharides on Carbon Tetrachloride-Induced Early Liver Fibrosis in Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Carbon tetrachloride</style></keyword><keyword><style  face="normal" font="default" size="100%">Crude polysaccharides</style></keyword><keyword><style  face="normal" font="default" size="100%">Fibrosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Ganoderma applanatum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1428-1436</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Liver fibrosis is a treatable disease when still at early stages. &lt;em&gt;Ganoderma applanatum &lt;/em&gt;plays role as alternative medicine. The fungi have antioxidant, anti-inflammatory, and anticancer bioactivities. This study aimed to evaluate the hepatoprotective effects of &lt;em&gt;G. applanatum &lt;/em&gt;crude polysaccharides (GACP) on liver fibrosis due to CCl4 induction. &lt;strong&gt;Methods&lt;/strong&gt;: This study was divided into six groups. BALB/c mice were given CCl4 dissolved in olive oil (2 mL/kg; 1:3) intraperitoneally (i.p) twice a week for four weeks to produce a liver fibrosis model. Distilled water (control group), silymarin 100 mg/kg and GACP 25, 50, 100 mg/kg were given once daily for four weeks. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis-α (TNF-α) and interleukin-6 (IL-6) were determined by enzyme-linked immunosorbent assay (ELISA) kit. Histopathology was stained by hematoxylin &amp;amp; eosin (H&amp;amp;E) and Masson’s trichome.&lt;strong&gt; Results: &lt;/strong&gt;The administration of GACP effectively prevented ALT, AST, TNF-α, and IL-6 levels from high elevation. Additionally, the GACP had protective effect after liver histological analysis exhibited less injury in the liver tissue.&lt;strong&gt; Conclusion: &lt;/strong&gt;The hepatoprotective effect of GACP on liver fibrosis is mainly due to avoid high elevation of pro-inflammatory cytokine. This result revealed that GACP could be a potential hepatoprotective agent for later clinical therapy.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1428</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Raden Joko Kuncoroningrat Susilo&lt;sup&gt;1&lt;/sup&gt;, Dwi Winarni&lt;sup&gt;1,*&lt;/sup&gt;, Saikhu Akhmad Husen&lt;sup&gt;1&lt;/sup&gt;, Suhailah Hayaza&lt;sup&gt;1&lt;/sup&gt;, Sri Puji Astuti Wahyuningsih&lt;sup&gt;1&lt;/sup&gt;, Ruey-An Doong&lt;sup&gt;1,2&lt;/sup&gt;, Win Darmanto&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya 60115, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Institute of Analytical and Environmental Sciences, National Tsing Hua University, Sec. 2 Kuang Fu Road, Hsinchu 30013, TAIWAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">SM Abdul Aziz Barbhuiya</style></author><author><style face="normal" font="default" size="100%">SH Victoria Devi</style></author><author><style face="normal" font="default" size="100%">Ajay Kakati</style></author><author><style face="normal" font="default" size="100%">Rejwan Ahmed Choudhury</style></author><author><style face="normal" font="default" size="100%">Muslek Uddin Mazumder</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Pharamacognostic Profile and Comparative in vitro Anti- Inflammatory Activity Study of Ethanomedicinal Plants of North East India</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Diclofenac sodium</style></keyword><keyword><style  face="normal" font="default" size="100%">Macroscopic</style></keyword><keyword><style  face="normal" font="default" size="100%">Microscopic</style></keyword><keyword><style  face="normal" font="default" size="100%">Northeast India</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacognostic study</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">317-324</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; In ethno-medicinal practices, the leaves of &lt;em&gt;Alocasia macrrorhizos&lt;/em&gt;, &lt;em&gt;Canavalia ensiformis, Amaranthus cruentus, Averrhoea carambola, Bauhina tenifloara&lt;/em&gt;&amp;nbsp;and &lt;em&gt;Capsicum Chinese&lt;/em&gt; have different pharmacological activities. The problem encountered with the proper utilization of herbal drugs is lack of documentation and standard parameter, which create problem in acceptance and importance of these plants. &lt;strong&gt;Objective:&lt;/strong&gt; The objectives of our study are to establish scientifically evaluated pharmacognostic profile and &lt;em&gt;in vitro&lt;/em&gt; antiinflammatory screening of six plants. &lt;strong&gt;Methods:&lt;/strong&gt; Leaf sample from each plant was evaluated by macroscopic, microscopic and physicochemical parameters (As per WHO recommended methods of standardization). The anti-inflammatory activity screening of methanolic extracts was carried out against inhibition of protein denaturation method taking diclofenac sodium as a benchmark. &lt;strong&gt;Results: &lt;/strong&gt;The macroscopic characteristic and microscopical evaluation reveals the type of stomata within the leaves and presence of parenchyma cells, collenchyma cells, upper epidemis, lower epidermis, vascular bundle, palisade cells and trichomes in the transverse section of leaves. Physicochemical parameter reveals the total ash, acid insoluble ash, water soluble, methanol soluble extractives and moisture content. The IC&lt;sub&gt;50&lt;/sub&gt; value of &lt;em&gt;MEAM, MECE, MEAC, MEAC1, MECC&lt;/em&gt;&amp;nbsp;and &lt;em&gt;MEBT&lt;/em&gt; against inhibiton of protein denaturation was found to be 72.88, 841.78, 735.12, 303.75, 188, and 354.1855 μg/mL respectively. &lt;strong&gt;Conclusion: &lt;/strong&gt;The present study contributes useful information that will help in the exact identification as well as assessment of purity of crude drugs. Methanolic extract of&lt;em&gt; Alocasia macrorrhizos&lt;/em&gt; could be a potential anti-inflammatory agent from the natural sources.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">317</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;SM Abdul Aziz Barbhuiya, SH Victoria Devi*, Ajay Kakati, Rejwan Ahmed Choudhury, Muslek Uddin Mazumder&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Regional Institute of Paramedical and Nursing Sciences, Zemabawk, Aizwal - 796017, Mizoram, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Amira Horchani</style></author><author><style face="normal" font="default" size="100%">Fadwa Chaabane</style></author><author><style face="normal" font="default" size="100%">Mahassen Barboura</style></author><author><style face="normal" font="default" size="100%">Imen Mokdad-Bzeouich</style></author><author><style face="normal" font="default" size="100%">Aimen Abbassi</style></author><author><style face="normal" font="default" size="100%">Amine Trabelsi</style></author><author><style face="normal" font="default" size="100%">Leila Chekir-Ghedira</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemistry and Biological Evaluation of Daphne gnidium L. Butanol Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Analgesic</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Daphne gnidium</style></keyword><keyword><style  face="normal" font="default" size="100%">Lysosmal activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Nitric oxide production.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">1688-1693</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Daphne gnidium &lt;/em&gt;L. (Thymelaeaceae) has been used in the Mediterranean basin to treat skin diseases, rheumatism and toothache.&amp;nbsp;&lt;strong&gt;Objective: &lt;/strong&gt;the aim of this study was to evaluate the biological activities of butanol extract from the &lt;em&gt;D. gnidium&lt;/em&gt; leaves. &lt;strong&gt;Methods: &lt;/strong&gt;A quantitative analysis by high‐performance liquid chromatography with a diode array detector (HPLC‐DAD) was performed. The antioxidant activities were evaluated by using three different assays: 2,2-diphenyl-l-picrylhydrazyl assay (DPPH assay), deoxyribose degradation assay and Cellular Antioxidant Activity (CAA) assay. The butanol extract was investigated for anti-inflammatory and analgesic activities in animal models. In addition, its effect on the production of NO and lysosomal activity &lt;em&gt;in vivo &lt;/em&gt;was assessed. &lt;strong&gt;Results: &lt;/strong&gt;The HPLC-DAD analysis showed the presence of daphnetin. The butanol extract had a remarkable antioxidant activity in the different systems tested. Furthermore, it has an anti-inflammatory effect by inhibiting the xyleneinduced ear edema and reduced the number of abdominal constrictions in mice indicating analgesic effect. It also was found to inhibit (NO) production and lysosomal activity &lt;em&gt;in vivo&lt;/em&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; These findings support the daphne use in traditional medicine for its analgesic and anti-inflammatory activities. Further investigations to elucidate its mechanism of action are required.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1688</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Amira Horchani&lt;sup&gt;1,&lt;/sup&gt;*, Fadwa Chaabane&lt;sup&gt;1&lt;/sup&gt;, Mahassen Barboura&lt;sup&gt;1&lt;/sup&gt;, Imen Mokdad-Bzeouich&lt;sup&gt;1&lt;/sup&gt;, Aimen Abbassi&lt;sup&gt;1&lt;/sup&gt;, Amine Trabelsi&lt;sup&gt;1&lt;/sup&gt;, Leila Chekir-Ghedira&lt;sup&gt;1,2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Unit of natural bioactive substances and biotechnology, Faculty of Pharmacy of Monastir, 5000, TUNISIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Laboratory of Cell and Molecular Biology, Faculty of Dental Medicine of Monastir,5000, TUNISA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Twinkle Francis</style></author><author><style face="normal" font="default" size="100%">S Rajeshkumar</style></author><author><style face="normal" font="default" size="100%">Anita Roy</style></author><author><style face="normal" font="default" size="100%">T Lakshmi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-inflammatory and Cytotoxic Effect of Arrow Root Mediated Selenium Nanoparticles</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Brine shrimp</style></keyword><keyword><style  face="normal" font="default" size="100%">Green synthesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Selenium nanoparticles</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1363-1367</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Nanoparticles serve to reduce toxicity, enhance bioactivity and improve targeting. Selenium nanoparticles (SeNPs) are explored because of it’s unique characteristics and various known therapeutic benefits such as antioxidants activities and reducing risk of cancer. In this study, arrow root which is a starch obtained from tapioca or cassava is mediated with SeNPs and studied for it’s anti-inflammatory and cytotoxic effect. The plant extract of arrow root was prepared and mixed with the sodium selenite solution. The solution is kept in a magnetic stirrer while being observed for any colour change. The synthesis of nanoparticles is observed using UV-vis spectrophotometry. Then the anti-inflammatory activity is observed using albumin denaturation assay and cytotoxic analysis conducted on brine shrimp nauplii. The results showed that there was a lower toxicity rate of SeNPs and significant anti-inflammatory activity which concludes that these nanoparticles can be used in various drug designing aspects in future.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1363</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Twinkle Francis, S Rajeshkumar*, Anita Roy, T Lakshmi &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Nanobiomedicine Lab, Department of Pharmacology, Saveetha Dental College and Hospital, SIMATS, Chennai – 600077, TN, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Manish Kumar</style></author><author><style face="normal" font="default" size="100%">Ankita Misra</style></author><author><style face="normal" font="default" size="100%">Akanksha Srivastava</style></author><author><style face="normal" font="default" size="100%">Pushpendra Kumar Shukla</style></author><author><style face="normal" font="default" size="100%">L M Tewari</style></author><author><style face="normal" font="default" size="100%">Sharad Srivastava</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Comparative Pharmacognostical and Pharmacological Evaluation of Costus speciosus (Koen) J.E. Sm. Germplasm Collected from Eastern Ghats of India</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-diabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Costus speciosus</style></keyword><keyword><style  face="normal" font="default" size="100%">Diosgenin</style></keyword><keyword><style  face="normal" font="default" size="100%">HPTLC</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February  2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">150-156</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Costus speciosus &lt;/em&gt;is an erect perennial herb belonging to family Costaceae, an important medicinal plant widely used in several indigenous medicinal formulations. &lt;strong&gt;Objective: &lt;/strong&gt;A comparative evaluation of Pharmacognostical and Pharmacological potential of &lt;em&gt;Costus speciosus &lt;/em&gt;for the validation of traditional claims and quality parameters for industry. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Pharmacognostical studies were performed as per Ayurvedic Pharmacopeia of India and quantification of diosgenin was done through HPTLC. &lt;em&gt;In vitro&lt;/em&gt; antidiabetic activity was evaluated by α-amylase inhibition assay based on starch iodine method and &lt;em&gt;in vitro &lt;/em&gt;anti-inflammatory were done by using inhibition of protein denaturation assay. &lt;strong&gt;Results: &lt;/strong&gt;The pharmacognostical standards were also laid down for each sample. Morpho-anatomical characters had no distinct variation in all the collected samples of Eastern Ghats. The quantification of diosgenin (without hydrolysis of samples) in the collected germplasm varies significantly from 0.002 to 0.076 % on dry weight basis. The maximum content was recorded in NBCS-06 from Patiya, Bhubaneswar and was identified as distinct chemotype with high metabolite content. IC&lt;sub&gt;50&lt;/sub&gt; value of&lt;em&gt; Costus speciosus &lt;/em&gt;extract in starch-iodine assay was found to be maximum in NBCS- 6 (87.54 μg/ml) and inhibition of protein denaturation assay was found to be maximum in NBCS- 11 (73.91 μg/ml), respectively. &lt;strong&gt;Conclusion: &lt;/strong&gt;The study suggests that the &lt;em&gt;Costus speciosus&lt;/em&gt; germplasm possess potential anti-inflammatory and anti-diabetic activity and comparative pharmacognostical parameters will be useful in collection of location specific potential samples for industrial usage along with quality control of raw materials.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">150</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Manish Kumar&lt;sup&gt;1,2&lt;/sup&gt;, Ankita Misra&lt;sup&gt;1&lt;/sup&gt;, Akanksha Srivastava&lt;sup&gt;1&lt;/sup&gt;, Pushpendra Kumar Shukla&lt;sup&gt;1&lt;/sup&gt;, L. M. Tewari&lt;sup&gt;2&lt;/sup&gt;, Sharad Srivastava&lt;sup&gt;1,&lt;/sup&gt;*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacognosy Division, CSIR-National Botanical Research Institute, Lucknow (U.P.) 226001, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Botany, D.S.B. Campus, Kumaun University, Nainital-263002, Uttarakhand, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Saleh A Almatroodi</style></author><author><style face="normal" font="default" size="100%">Ahmad Almatroudi</style></author><author><style face="normal" font="default" size="100%">Mohammed A Alsahli</style></author><author><style face="normal" font="default" size="100%">Arshad Husain Rahman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Grapes and their Bioactive Compounds: Role in Health Management Through Modulating Various Biological Activities</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-tumour</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Proanthocyanidins</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitis vinifera</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1455-1462</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;em&gt;Grape&lt;/em&gt; is one of the important plant and its implication in health management has been proven. Grapes are used in the production of grape juice, food products and in other form. The fruits leaves and seeds of the plant are confirmed its role in diseases management based on &lt;em&gt;in vivo&lt;/em&gt; and &lt;em&gt;in vitro&lt;/em&gt; study. Leaves, fruits and seeds of grape are rich source of bioactive compounds and such compound play role in diseases cure and management. Grapes leaves, fruits and seeds shows therapeutic implications as antioxidant, anti-inflammatory, anti-diabetic, hepatoprotective effect and antimicrobial. Grapes leave, fruit and seed and their active compounds play significant role in inhibition of cancer. Its bioactive compound has designated its role in tumour management through modulating genes activity. This review comprehensively summarizes the role of grapes fruits, seeds and leaves in diseases management through modulating different biological activities based on&lt;em&gt; in vivo&lt;/em&gt; and &lt;em&gt;in vitro &lt;/em&gt;study.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1455</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Saleh A. Almatroodi&lt;sup&gt;1&lt;/sup&gt;, Ahmad Almatroudi&lt;sup&gt;1&lt;/sup&gt;, Mohammed A. Alsahli&lt;sup&gt;1&lt;/sup&gt;, Arshad Husain Rahmani&lt;sup&gt;1,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Medical Laboratories, College of Applied Medical Sciences, Buraidah 52571, Qassim University, SAUDI ARABIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Elsa Badriyya</style></author><author><style face="normal" font="default" size="100%">Salman</style></author><author><style face="normal" font="default" size="100%">Amalia Refina Pratiwi</style></author><author><style face="normal" font="default" size="100%">Dwisari Dillasamola</style></author><author><style face="normal" font="default" size="100%">Yufri Aldi</style></author><author><style face="normal" font="default" size="100%">Elidahanum Husni</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Topical Anti-Inflammatory Activity of Bromelain</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Bromelain</style></keyword><keyword><style  face="normal" font="default" size="100%">Exudate</style></keyword><keyword><style  face="normal" font="default" size="100%">Gel</style></keyword><keyword><style  face="normal" font="default" size="100%">Granuloma</style></keyword><keyword><style  face="normal" font="default" size="100%">Leukocyte</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1586-1593</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Bromelain is a proteolytic enzyme found in pineapple plants. &lt;strong&gt;Aim:&lt;/strong&gt; This study conducted to determine the activity of bromelain enzyme as an anti-inflammatory using the Granuloma Pouch method. &lt;strong&gt;Methods: &lt;/strong&gt;The experimental animals were divided into five groups, namely the positive control group, the bromelain concentration group of 0.1%; 0.5%; 1%, and the comparison group. Experimental animals induced carrageenan 2% subcutaneously. The dosage form is given topically for 2, 4, and 6 days. The observation was made by measuring the volume of edema, the total number, and the percentage of leukocyte cells on days 2, 4, and 6. &lt;strong&gt;Results:&lt;/strong&gt; The observation results of a positive control group, bromelain concentration 0.1%, 0.5%, 1%, and the comparators, there was a significant decrease for the volume of exudate on days 2, 4, and 6 (p&amp;lt;0.05). The average total number of leukocytes also decreased significantly (p&amp;lt;0.05) in the positive control, the bromelain, and comparison group in day 2, 4, and 6. At the same time, the mean leucocyte percentage had no effect (p&amp;gt;0.05). &lt;strong&gt;Conclusion: &lt;/strong&gt;From the results of the study, it was concluded that the bromelain enzyme at concentration 0.1%, 0.5%, and 1% have an anti-inflammatory effect by suppressing the volume of exudate, and the total number of leucocyte.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1586</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Elsa Badriyya, Salman, Amalia Refina Pratiwi, Dwisari Dillasamola, Yufri Aldi, Elidahanum Husni* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Faculty of Pharmacy, University Andalas, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Em Sutrisna</style></author><author><style face="normal" font="default" size="100%">Maryati</style></author><author><style face="normal" font="default" size="100%">Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Tanti Azizah S</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-inflammatory Effect of Phyllanthus niruri L. from Indonesia (Pre-clinical Study)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Carrageenan</style></keyword><keyword><style  face="normal" font="default" size="100%">Phyllanthus niruri L.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1347-1350</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Indonesian people often use &lt;em&gt;Phyllanthus niruri&lt;/em&gt; L. (&lt;em&gt;P. niruri&lt;/em&gt; L.) to treat pain. Pain is the one of symptoms of inflammation. Some people take traditional medicine to treat this pain, because some analgesic drugs have several adverse effects. The aim of this research is to explore the anti-inflammatory effect of ethyl asetat fraction of ethanolic extract of &lt;em&gt;P. niruri&lt;/em&gt; L. (EAPN) from Indonesia in rats induced by carrageenan. A total of 25 rats were divided into 5 groups. Group 1 (diclofenac sodium 50 mg/kgbb), group 2 (aqueous extract), groups 3,4and 5 were ethyl asetat fraction at dosage of 250; 500 and 1000 mg/kgbw respectively. Group 1 was treated by diclofenac sodium at dose of 50 mg/kgbw, group II was treated by aqueous 2mL/rats, groups III, IV and V were treated by EAPN at dosage of 250; 500 and 1000mg/kgbw respectively. Thirty minutes later, all rats were injected by carrageenan 0,1 mL 1% w/v sub cutaneous into back rat’s left paw. Paw volumes were measured by Plethysmometer on minutes 0, 60, 90, 150, 210, 330. Area under the curve (AUC) were calculated from these results (AUC 0-30; AUC 0-90; 0-150; AUC 0-210 and AUC 0-330). The AUC of EAPN at dosage of 250; 500 and 1000mg/ kgbw smaller than negative control significantly (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.05). EAPN contains alkaloids, flavonoids, terpenoids, saponins and triterpens. EAPN has anti-inflammatory effect in rats induced by carrageenan.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1347</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Em Sutrisna&lt;sup&gt;1&lt;/sup&gt;,*, Maryati&lt;sup&gt;2&lt;/sup&gt;, Sri Wahyuni&lt;sup&gt;2&lt;/sup&gt;, Tanti Azizah S&lt;sup&gt;2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Medical faculty of Universitas Muhammadiyah Surakarta, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacy faculty of Universitas Muhammadiyah Surakarta, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vigasini Subbiah</style></author><author><style face="normal" font="default" size="100%">Pannaga Nagaraja</style></author><author><style face="normal" font="default" size="100%">Priya Narayan</style></author><author><style face="normal" font="default" size="100%">Holenarasipur GunduRao Nagendra</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Pharmacological Properties of Caesalpinia bonducella Seed and Shell Extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-diabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-mitotic</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-oxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Caesalpinia bonducella</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January-2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">150-154</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Background:&lt;/strong&gt;&lt;em&gt; Caesalpinia bonducella&lt;/em&gt; L. is a medicinal plant belonging to the family Caesalpiniaceae. It is a prickly shrub widely distributed all over the world especially in Indian tropical regions such as Kerala, Andaman and Nicobar Islands and Sri Lanka. There are claims that its leaves or seeds/ seed kernel possess antipyretic, antidiuretic, antibacterial, antiviral, antiestrogenic and antidiabetic activities Due to the above properties several preparations of the plant were used in folk medicine.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; The aqueous extract of &lt;em&gt;Caesalpinia bonducella&lt;/em&gt; nut containing the seed and the shell, has been evaluated for qualitative analysis of secondary metabolites (tannis, flavonoids, alkaloids, saponins, coumarins, quinone and phenols), in-vitro anti -inflammatory, anti-diabetic assay, antioxidant, antimitotic and antimicrobial activity. The studies were carried out using HRBC membrane stabilization, inhibition of alpha amalyse enzyme, DPPH method, green gram growth inhibition, agar diffusion method respectively. &lt;strong&gt;Results:&lt;/strong&gt; Our results indicate the presence of Alkaloids, Flavanoids and Saponins. We report in our study the antidiabetic, anti-inflammatory, anti-oxidant, anti-microbial and antimitotic activity of &lt;em&gt;Caesalpinia bonducella.&lt;/em&gt;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">150</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Vigasini Subbiah, Pannaga Nagaraja, Priya Narayan&lt;sup&gt;*&lt;/sup&gt;, Holenarasipur GunduRao Nagendra &lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Department of Biotechnology, Sir M Visvesvaraya Institute of Technology, Hunasamaranahalli, Bangalore- 562 157, Karnataka, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sendangratri</style></author><author><style face="normal" font="default" size="100%">Rosita Handayani</style></author><author><style face="normal" font="default" size="100%">Berna Elya</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Inhibitory Effects of Different Varieties of Sweet Potato (Ipomoea batatas L.) Tubers Extracts on Lipoxygenase Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Ipomoea batatas L</style></keyword><keyword><style  face="normal" font="default" size="100%">Lipoxygenase</style></keyword><keyword><style  face="normal" font="default" size="100%">Sweet potato tubers</style></keyword><keyword><style  face="normal" font="default" size="100%">Total flavonoid contents</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1195-1198</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;Sweet potatoes (&lt;em&gt;Ipomoea batatas&lt;/em&gt; L.) with purple, orange and white varieties can be differentiated by their skin and flesh tubers’ colors. Research on anti-inflammatory activity of this plant is still limited although has been used traditionally. &lt;strong&gt;Objective:&lt;/strong&gt; This study aimed to determine IC&lt;sub&gt;50 &lt;/sub&gt;value of sweet potato tubers extracts in inhibiting lipoxygenase activity. &lt;strong&gt;Methods:&lt;/strong&gt; Dried tubers of sweet potato were macerated with ethanol 70%. Each extracts were tested for soybean lipoxygenase inhibitory activity, phytochemical screening and total flavonoid contents. IC&lt;sub&gt;50&lt;/sub&gt; value and total flavonoid contents obtained from each extracts were analyzed statistically. &lt;strong&gt;Results: &lt;/strong&gt;IC&lt;sub&gt;50 &lt;/sub&gt;value of purple, orange and white sweet potato tubers extracts are 46.09, 52.12 and 63.69 μg/mL respectively. Each extracts contain alkaloids, flavonoids, saponins, tannins and glycosides. Total flavonoid contents in purple, orange and white sweet potato extracts are 8.45±0.41; 7.57±0.03; and 6.12±0.14 mgQE/g extract respectively. &lt;strong&gt;Conclusion: &lt;/strong&gt;Total flavonoid contents and IC&lt;sub&gt;50&lt;/sub&gt; values of each extracts are strongly correlated and inversely proportional with significance value of 0.026 and correlation value of -0.999 which indicate that the higher total flavonoid contents, the stronger inhibitory activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1195</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Sendangratri&lt;sup&gt;1&lt;/sup&gt;, Rosita Handayani&lt;sup&gt;1&lt;/sup&gt;, Berna Elya&lt;sup&gt;1&lt;/sup&gt;,* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Pharmacognosy- Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ismael Leon-Rivera</style></author><author><style face="normal" font="default" size="100%">Juana Villeda-Hernandez</style></author><author><style face="normal" font="default" size="100%">Elizur Montiel-Arcos</style></author><author><style face="normal" font="default" size="100%">Isaac Tello</style></author><author><style face="normal" font="default" size="100%">Maria Yolanda Rios</style></author><author><style face="normal" font="default" size="100%">Samuel Estrada-Soto</style></author><author><style face="normal" font="default" size="100%">Angelica Berenice Aguilar</style></author><author><style face="normal" font="default" size="100%">Veronica Nunez-Urquiza</style></author><author><style face="normal" font="default" size="100%">Jazmin Mendez-Miron</style></author><author><style face="normal" font="default" size="100%">Victoria Campos-Pena</style></author><author><style face="normal" font="default" size="100%">Sergio Hidalgo-Figueroa</style></author><author><style face="normal" font="default" size="100%">Eva Hernandez</style></author><author><style face="normal" font="default" size="100%">Gerardo Hurtado</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Neuroprotective Effects of Ganoderma curtisii Polysaccharides After Kainic Acid-Seizure Induced</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticonvulsant</style></keyword><keyword><style  face="normal" font="default" size="100%">Ganoderma curtisii</style></keyword><keyword><style  face="normal" font="default" size="100%">Neuroprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">β-glucan</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1046-1054</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Epilepsy is one of the major neurological disorders affecting world population. Although, some &lt;em&gt;Ganoderma&lt;/em&gt; species have shown neuroprotective activities, the effects of polysaccharides isolated from &lt;em&gt;Ganoderma curtisii&lt;/em&gt; on epileptic seizures have not been reported. &lt;strong&gt;Objective:&lt;/strong&gt; The aims of the present study were to determine whether treatment with a polysaccharide fraction (GCPS-2) from a Mexican &lt;em&gt;Ganoderma curtisii &lt;/em&gt;strain can reduce seizures, and the increases in the levels of apoptotic molecules and inflammatory cytokines in kainic acid-induced seizure mouse model. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Rats were separated in groups: Control group received 2.5% Tween 20 solution; GCPS-2 groups were administered GCPS-2 (10, 40, or 80 mg/kg); KA group received KA 10 mg/kg; GCPS-2+KA received GCPS- 2 and 30 min later KA. Pathological changes in neuronal morphology, expression of B-cell lymphoma-2, and pro-inflammatory cytokines (interleukin1-β and tumor necrosis factor-α) in the rat hippocampus and cortex were determined by immunohistochemistry.&lt;strong&gt; Results: &lt;/strong&gt;&lt;em&gt;Ganoderma curtisii&lt;/em&gt; soluble polysaccharides (GCPS-2) inhibited convulsions in rats. Moreover, treatment with GCPS-2 reduced the increased levels of apoptotic signaling molecules (Bcl-2) and proinflammatory mediators (in the kainic acid-treated hippocampus and cortex). &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Ganoderma curtisii&lt;/em&gt; soluble polysaccharides have a neuroprotective potential against epilepsy, partially through its ability to inhibit neurotoxic events in the &lt;em&gt;in vivo&lt;/em&gt; hippocampus and cortex.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1046</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ismael León-Rivera&lt;sup&gt;1&lt;/sup&gt;*, Juana Villeda-Hernández&lt;sup&gt;2&lt;/sup&gt;, Elizur Montiel-Arcos&lt;sup&gt;3&lt;/sup&gt;, Isaac Tello&lt;sup&gt;3&lt;/sup&gt;, María Yolanda Rios&lt;sup&gt;1&lt;/sup&gt;, Samuel Estrada-Soto&lt;sup&gt;4&lt;/sup&gt;, Angélica Berenice Aguilar&lt;sup&gt;1&lt;/sup&gt;, Verónica Núñez-Urquiza&lt;sup&gt;1&lt;/sup&gt;, Jazmín Méndez-Mirón&lt;sup&gt;5&lt;/sup&gt;, Victoria Campos-Peña&lt;sup&gt;2&lt;/sup&gt;, Sergio Hidalgo-Figueroa&lt;sup&gt;6&lt;/sup&gt;, Eva Hernández&lt;sup&gt;7&lt;/sup&gt;, Gerardo Hurtado&lt;sup&gt;7&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Centro de Investigaciones Químicas, IICBA, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez. Avenida Insurgentes Sur No. 3877 Col. La Fama Tlalpan, Ciudad de México, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Autónoma del Estado de Morelos, Avenida Universidad 1001, Col. Chamilpa 62209 Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;CONACYT-IPICYT Consorcio de Investigación, Innovación y Desarrollo para las Zonas Áridas, 78216 San Luis Potosí, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;7&lt;/sup&gt;Instituto Nacional de Salud Pública. Avenida Universidad 565, Col. Santa María Ahuacatitla Cuernavaca, Morelos, ESTADOS UNIDOS MEXICANOS.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rima Boukhary</style></author><author><style face="normal" font="default" size="100%">Maha Aboul-Ela</style></author><author><style face="normal" font="default" size="100%">Abdalla El-Lakany</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Review on Chemical Constituents and Biological Activities of Genus Anthemis</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anthemis</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-oxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Flavonoids</style></keyword><keyword><style  face="normal" font="default" size="100%">Sesquiterpenes</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">1155-1166</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;Genus &lt;em&gt;Anthemis&lt;/em&gt; of Family Asteraceae contains mainly flavonoids, sesquiterpene lactones belonging to germacranolides, eudesmanolides, guaianolides, sterols and essential oils. The Plants of genus Anthemis have been known to have anti-inflammatory, hepatoprotective and antioxidant activities due to their rich contents of important physiological and biological compounds. They are referred to as nature’s biological response modifier’s and are involved in energy transfer, photosensitization and morphogenesis. Several clinical studies have shown that people who take diets rich in flavonoids and sesquiterpenes have reduced risk of developing cancer and cardiovascular diseases. This article covers most of constituents of plants of genus Anthemis reported from 2002 up to 2018. Furthermore, the biological activities of plants of genus Anthemis will be presented.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1155</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Rima Boukhary*, Maha Aboul- ElA, Abdalla El-Lakany&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Beirut Arab University, 115020 Beirut, LEBANON.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Salah Eddine Marref</style></author><author><style face="normal" font="default" size="100%">Naima Benkiki</style></author><author><style face="normal" font="default" size="100%">Mohamed Akram Melakhessou</style></author><author><style face="normal" font="default" size="100%">Soumia Bouzidi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Acute Toxicity, Anti-ulcer and Anti-inflammatory Effects of Methanol Extract of Gladiolus segetum in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antiulcer genic</style></keyword><keyword><style  face="normal" font="default" size="100%">Gastric ulcer</style></keyword><keyword><style  face="normal" font="default" size="100%">Gladiolus segetum</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">June 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/665</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">758-762</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&lt;/strong&gt; To evaluate the &lt;em&gt;in vivo&lt;/em&gt; anti-ulcer and anti-inflammatory activities of methanol extract of the aerial parts of &lt;em&gt;Gladiolus segetum&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; First methanol extract of &lt;em&gt;Gladiolus segetum&lt;/em&gt; was subjected to the acute oral toxicity test according to the OECD, guideline no 423.The anti-ulcer activity of &lt;em&gt;Gladiolus segetum&lt;/em&gt; was investigated by ethanol induced gastric ulcer in Wistar rats. Methanol extract was administered by gavage one hour before ethanol to the different groups at a dose corresponding of 100,250 and 500 mg/kg body weight. The control group received normal saline in comparable volume (10ml/kg body weight) by the same route. The anti-inflammatory activity of the tested extract was evaluated in adult wistar rats by the egg albumin induced paw edema method. &lt;strong&gt;Results:&lt;/strong&gt; A significant reduction (&lt;em&gt;p&lt;/em&gt; &amp;lt;0.001) was observed in the results of the present study, revealed that methanol extract possessed gastroprotective activity and exerts a topical anti-inflammatory effect &lt;em&gt;in vivo&lt;/em&gt;. &lt;strong&gt;Conclusion:&lt;/strong&gt; These results suggest that methanol extract of &lt;em&gt;Gladiolus segetum&lt;/em&gt; may represent an important clinical alternative in anti-inflammatory and antiulcer genic therapeutics.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">758</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Salah Eddine Marref*, Naima Benkiki, Mohamed Akram Melakhessou, Soumia Bouzidi &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Laboratoire de Biotechnologie des Mol&amp;eacute;cules Bioactives et de la Physiopathologie Cellulaire. Universit&amp;eacute; de Batna-2, 05000, ALG&amp;Eacute;RIE.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sirirat Deeseenthum</style></author><author><style face="normal" font="default" size="100%">Vijitra Luang-In</style></author><author><style face="normal" font="default" size="100%">Supaporn Chunchom</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Characteristics of Thai Pigmented Rice Milk Kefirs with Potential as Antioxidant and Anti-Inflammatory Foods</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Lactic acid</style></keyword><keyword><style  face="normal" font="default" size="100%">Rice kefir</style></keyword><keyword><style  face="normal" font="default" size="100%">Thai color rice</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/412</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">154-161</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aims:&lt;/strong&gt; The characteristics, antioxidant property of Hawm Nil rice (Purple rice), Red Hawm rice (Red rice), Khao Dawk Mali 105 rice (White rice) milk kefirs and mixing of three color rice milk kefir in different ratios were investigated. Then, anti-inflammatory activity of Hawm Nil rice kefir was studied. &lt;strong&gt;Methodology:&lt;/strong&gt; The physiochemical properties, total phenolic compounds and antioxidant activities of these rice milk kefirs were investigated. Anti-inflammatory measurements were performed to study blood chemistry, hematological values and tumor necrosis factor-a (TNF-a) level in colitis rats compared with rats treated with prednisolone (positive control) and cow&amp;rsquo;s milk kefir. &lt;strong&gt;Results:&lt;/strong&gt; All the rice kefir formulas had lower pH values than the cow&amp;rsquo;s milk kefir. Moreover, they all exhibited no changing viscosity. Lactic acid concentrations increased in cow&amp;rsquo;s milk kefir during 24-48 h. Alcohol concentrations in all the rice formulas increased within 24-48 h, while cow&amp;rsquo;s milk only increased at 72 h. Antioxidant activity, most of the rice milk kefirs had antioxidant activity higher than cow&amp;rsquo;s milk by DPPH assay. In addition, the Hawm Nil rice milk kefir had high antioxidant activity by DPPH assay and FRAP assay. Blood chemistry, hematological values and tumor necrosis factor-&amp;alpha; (TNF-&amp;alpha;) levels in colitis rats treated with Hawm Nil rice milk kefir did not differ from those treated with prednisolone and cow&amp;rsquo;s milk kefir. TNF-&amp;alpha; in the serum of colitis rats treated with Hawm Nil rice milk kefir was significantly reduced when compared to the PBS buffer. &lt;strong&gt;Conclusion:&lt;/strong&gt; The findings indicated that color rice kefirs may offer protection against chemically induced tissue injury. Hawm Nil rice milk kefir exerted potential antioxidant and anti-inflammatory activities and was safe for human consumption. Other Thai colored rice will be used to develop Thai rice milk kefir products as new and antioxidant-rich beverages and functional foods for human health benefits in the future.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">154</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Sirirat Deeseenthum*, Vijitra Luang-In, Supaporn Chunchom &lt;/strong&gt;&lt;/p&gt;
&lt;p&gt;Natural Antioxidant Innovation Research Unit, Faculty of Technology, Mahasarakham, University, Khamriang Sub-district, Kantarawichai District, Maha Sarakham-44150, THAILAND.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Jorge Luis Arroyo-Acevedo</style></author><author><style face="normal" font="default" size="100%">Oscar Herrera-Calderon</style></author><author><style face="normal" font="default" size="100%">Juan Pedro Rojas-Armas</style></author><author><style face="normal" font="default" size="100%">Victor Chumpitaz-Cerrate</style></author><author><style face="normal" font="default" size="100%">César Franco-Quino</style></author><author><style face="normal" font="default" size="100%">Renán Hañari-Quispe</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chuquiraga spinosa Lessing: A Medicinal Plant for Gastric Cancer Induced By N-Methyl-N-Nitroso-Urea (NMU)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anticancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Chuquiraga spinosa</style></keyword><keyword><style  face="normal" font="default" size="100%">NMU</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/359</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">20-24</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Gastric cancer (GC) is one of the most frequent diseases in human population: Many plants from Peruvian flora is used to treat cancer as alternative treatment. &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; Lessing (ChS) is a species with high potential therapeutic due to its antioxidant and anti-inflammatory effect as well as protective against prostate cancer. &lt;strong&gt;Objective:&lt;/strong&gt; The main objective was to evaluate the possible protective effect of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; extract on NMU (N-methyl-N nitrosourea)-induced gastric cancer in rats. &lt;strong&gt;Methods:&lt;/strong&gt; Gastric carcinogenesis was induced in 30 male Holtzman rats by providing NMU 50 &amp;mu;g/Kg by oral administration for 16 weeks. Ethanolic extract of ChS aerial parts was administered at doses 50, 250 and 500 mg/Kg per oral. The protective effect was determined through weight controls, biochemical and hematological parameters; the antioxidant capacity by superoxide dismutase (SOD), nitric oxide (NO), malondialdehyde (MDA) and anti-inflammatory capacity by the level of C-reactive protein (CRP). The tumors were monitored by using histological examinations. &lt;strong&gt;Results:&lt;/strong&gt; Oral administration of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; extract significantly decreased superoxide dismutase malondialdehyde, nitric oxide, C-reactive protein levels (&lt;em&gt;p&lt;/em&gt;&amp;lt;0,01, &lt;em&gt;p&lt;/em&gt;&amp;lt;0,01, &lt;em&gt;p&lt;/em&gt;&amp;lt;0,01 and &lt;em&gt;p&lt;/em&gt;&amp;lt;0,01 respectively compared with Inductor group). There was a significant increase in the weights of animals (&lt;em&gt;P&lt;/em&gt;&amp;lt;0.05). &lt;strong&gt;Conclusion:&lt;/strong&gt; Considering the anti-inflammatory, antioxidant, and anticancer properties of &lt;em&gt;Chuquiraga spinosa&lt;/em&gt; extract, we conclude that it has a protective effect on NMU induced gastric cancer in rats.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">20</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Jorge Luis Arroyo-Acevedo&lt;sup&gt;1&lt;/sup&gt;, Oscar Herrera- Calderon&lt;sup&gt;2&lt;/sup&gt;*, Juan Pedro Rojas-Armas&lt;sup&gt;1&lt;/sup&gt;, Victor Chumpitaz-Cerrate&lt;sup&gt;3&lt;/sup&gt;, C&amp;eacute;sar Franco-Quino&lt;sup&gt;3&lt;/sup&gt;, Ren&amp;aacute;n Ha&amp;ntilde;ari-Quispe&lt;sup&gt;4 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Laboratory of Experimental Pharmacology, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima. PERU.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga de Ica, Ica, PERU.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Physiology and Pharmacology, Faculty of Dentistry, Universidad Nacional Mayor de San Marcos, Lima, PERU.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Laboratory of Animal Physiology, Universidad &amp;Aacute;ndina N&amp;eacute;stor C&amp;aacute;ceres Vel&amp;aacute;squez, Puno, PERU.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fatma Sri Wahyuni</style></author><author><style face="normal" font="default" size="100%">Daud Ahmad Israf Ali</style></author><author><style face="normal" font="default" size="100%">Nordin Hj. Lajis</style></author><author><style face="normal" font="default" size="100%">Dachriyanus</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-inflammatory activity of isolated compounds from the stem bark of Garcinia cowa Roxb</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia cowa</style></keyword><keyword><style  face="normal" font="default" size="100%">Nitric oxide</style></keyword><keyword><style  face="normal" font="default" size="100%">rubraxanthone</style></keyword><keyword><style  face="normal" font="default" size="100%">tetrapreniltoluquinone</style></keyword><keyword><style  face="normal" font="default" size="100%">α-mangostin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">55-57</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To find the anti inflammatory active compounds from methanol extract of &lt;em&gt;Garcinia cowa&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; To evaluate the inhibitory activity of isolated compounds on nitric oxide (NO) production, culture media was assayed using Griess reaction. An equal volume of Griess reagent (1% sulphanilamide and 0.1% N-(L-naphthyl)-ethylene diamine dihydrochloride, dissolved in 2.5% H3PO4) was mixed with culture supernatant and color development was measured at 550 nm using a micro plate reader. The amount of nitrite in the culture supernatant was calculated from a standard curve (0&amp;ndash;100 &amp;mu;M) of sodium nitrite freshly prepared in deionized water. Percentage of the NO inhibition was calculated by using nitrate level of IFN-&amp;gamma;/LPS-induced group as the control. &lt;strong&gt;Results:&lt;/strong&gt; Isolated compounds, tetraprenyltoluquinone, rubraxanthone and &amp;alpha;-mangostin from stem bark of &lt;em&gt;Garcinia cowa&lt;/em&gt; Roxb were evaluated for their anti-inflammatory activity. Only &amp;alpha;-mangostin exhibited strong anti-inflammatory activity with 83.42 % inhibition of NO and without inducing severe cytotoxicity at 50&lt;em&gt; &amp;mu;&lt;/em&gt;M. Rubraxanthone showed weak inhibition of NO with 23.86 % inhibition of NO while maintained 77.32 % of cell viability. TPTQ also showed the strong inhibition of NO with 80.98 % inhibition but unfortunately this compound also induced severe cytotoxicity with 39.62% viability. &lt;strong&gt;Conclusion:&lt;/strong&gt; &amp;alpha;-Mangostin exhibited strong anti-inflammatory activity without inducing severe cytotoxicity at 50 &lt;em&gt;&amp;mu;&lt;/em&gt;M. Rubraxanthone showed weak inhibition of NO while Tetraprenyltoluquinone also showed the strong inhibition of NO however this compound also induced severe cytotoxicity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">55</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Fatma Sri Wahyuni&lt;sup&gt;1&lt;/sup&gt;, Daud Ahmad Israf Ali&lt;sup&gt;2&lt;/sup&gt;, Nordin Hj. Lajis&lt;sup&gt;3&lt;/sup&gt; and Dachriyanus&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Pharmacy, Andalas University, Kampus Limau Manis, Padang, West Sumatra, Indonesia, 25163 &lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Faculty of Medicine and Health Sciences, University Putra Malaysia 43400 UPM, Serdang, Selangor, Malaysia &lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Laboratory of Natural Products, Institute of Bioscience, University Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Abdelsamed Ibrahim Elshamy</style></author><author><style face="normal" font="default" size="100%">Mohamed El-Shazly</style></author><author><style face="normal" font="default" size="100%">Yomna Mahmoud Yassine</style></author><author><style face="normal" font="default" size="100%">Mona Anwar El-Bana</style></author><author><style face="normal" font="default" size="100%">Abdel- Razik Farrag</style></author><author><style face="normal" font="default" size="100%">Mahmoud Ibrahim Nassar</style></author><author><style face="normal" font="default" size="100%">Abdel Nasser Singab</style></author><author><style face="normal" font="default" size="100%">Masaaki Noji</style></author><author><style face="normal" font="default" size="100%">Akemi Umeyama</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phenolic Constituents, Anti-Inflammatory and Antidiabetic Activities of Cyperus laevigatus L.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antidiabetic.</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cyperus Laevigatus</style></keyword><keyword><style  face="normal" font="default" size="100%">New Flavone</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/182</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">828-833</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Cyperus&lt;/em&gt; species are well known traditional plants and used for several diseases around the world. &lt;strong&gt;Aim of the Study:&lt;/strong&gt; Our study aimed to identification of the phenolic constituents in addition to evaluation of different extracts of &lt;em&gt;Cyperus laevigatus&lt;/em&gt; L as antioxidant, antiinflammatory and antidiabetic agents. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The phenolic constituents were identified using spectroscopic techniques. The antioxidant activity was evaluated using &lt;em&gt;in vitro&lt;/em&gt; DPPH assay. Total extract, methanol and EtOAc fractions were evaluated for their antiinflammatory activity using RAW 264.7 macrophages assay. Antidiabetic activity of the total extract was examined biochemically and histopathologically using streptozotocin-induced diabetic rats. &lt;strong&gt;Results:&lt;/strong&gt; A new flavone, chrysoeriol 7-&lt;em&gt;O&lt;/em&gt;-&amp;beta;-(6‴-&lt;em&gt;O-acetyl&lt;/em&gt;-&amp;beta;-D-glucopyranosyl)-(1&amp;rarr;4) glucopyranoside (1), along with seven knowns (2-8) were isolated from &lt;em&gt;Cyperus laevigatus&lt;/em&gt; L. The structures of isolated compounds were established depending upon 1D, 2D-NMR and HR-ESI-MS. The MeOH and EtOAc fractions exhibited significant antioxidant activity while the isolated flavonoids exhibited from moderate to weak antioxidant activity. The total extract, MeOH and EtOAc fractions exhibited significant anti-inflammatory activity using LPS-stimulated RAW 264.7 macrophages model by decreasing of NO accumulation by 76 &amp;ndash; 66% and 84 &amp;ndash; 67%, of the original accumulation values with increasing concentrations in comparison with the reference drug, dexamethasone. The total extract exhibited antidiabetic activity in streptozotocin-induced diabetic rats and this effect was manifested by decreasing serum levels of glucose, glucagon and NO. It also increased level of insulin and promoted paraoxonase activity. &lt;strong&gt;Conclusion:&lt;/strong&gt; These results proved that this plant may be multiple sources for medicinal natural drugs especially for anti-inflammatory and antidiabetic.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">828</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Abdelsamed Ibrahim Elshamy&lt;sup&gt;1,5*&lt;/sup&gt;, Mohamed El- Shazly&lt;sup&gt;2&lt;/sup&gt;, Yomna Mahmoud Yassine&lt;sup&gt;1&lt;/sup&gt;, Mona Anwar El- Bana&lt;sup&gt;3&lt;/sup&gt;, Abdel-Razik Farrag&lt;sup&gt;4&lt;/sup&gt;, Mahmoud Ibrahim Nassar&lt;sup&gt;1&lt;/sup&gt;, Abdel Nasser Singab&lt;sup&gt;2&lt;/sup&gt;, Masaaki Noji&lt;sup&gt;5&lt;/sup&gt;, Akemi Umeyama&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Natural Compounds Chemistry Department, National Research Centre, 33 El Bohouth st., Dokki, Giza, 12622, EGYPT.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo, EGYPT.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Medical Biochemistry Department, National Research Centre, 33 El Bohouth st., Dokki, Giza, 12622, EGYPT.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Pathology, National Research Centre, 33 El Bohouth st., Dokki, Giza, P.O. Box 12622, EGYPT.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, JAPAN.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arshad Husain Rahmani</style></author><author><style face="normal" font="default" size="100%">Amjad Ali Khan</style></author><author><style face="normal" font="default" size="100%">Yousef Homood Aldebasi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Saffron (Crocus sativus) and its Active Ingredients: Role in the Prevention and Treatment of Disease</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-tumour activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Crocus sativus</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity level.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/190</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">873-879</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Crocus sativus&lt;/em&gt; is a member of iridaceae family and its use in health management is in practice since ancient time. Additionally, research based on clinical trials and animal models have advocates its role in disease cure without any severe adverse complications. The aim of this study is to summarize the study of saffron and its ingredients based on &lt;em&gt;in vivo&lt;/em&gt; and &lt;em&gt;in vitro&lt;/em&gt; and role in disease cure and prevention. &lt;strong&gt;Materials:&lt;/strong&gt; This study was designed through the search engines such as Pub Med, Scopus and Google Scholar. The keywords used for the search were mainly focused on Saffron with health benefit and its therapeutics role in different diseases. &lt;strong&gt;Result:&lt;/strong&gt; Saffron stigma is mixture of various components and recent studies have proven that saffron and its active ingredients play a key role in disease management. Moreover, clinical trials based study on the use of saffron and its individual components have confirmed the health promising effects. &lt;strong&gt;Conclusion:&lt;/strong&gt; Although Saffron has potential role in the disease cure and prevention via modulation of anti-oxidant, anti-inflammatory, anti-tumour, anti-microbial and anti-diabetic activity. Furthermore, advanced research is needed to elaborate the role of saffron in health management and its mechanism of action in the modulation of biological activities.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">873</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Arshad Husain Rahmani&lt;sup&gt;1*&lt;/sup&gt;, Amjad Ali Khan &lt;sup&gt;2&lt;/sup&gt;, Yousef Homood Aldebasi&lt;sup&gt;3&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, SAUDI ARABIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Basic Health Science, College of Applied Medical Sciences, Qassim University, SAUDI ARABIA.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Optometry, College of Applied Medical Sciences, Qassim University, SAUDI ARABIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Tchimene Kenne Michel</style></author><author><style face="normal" font="default" size="100%">Anaga Arua Ottoh</style></author><author><style face="normal" font="default" size="100%">Ugwoke Christopher Emeka Chukwunonye</style></author><author><style face="normal" font="default" size="100%">Ezugwu Christopher Obodoike</style></author><author><style face="normal" font="default" size="100%">Okunji Christopher</style></author><author><style face="normal" font="default" size="100%">Iwu Maurice Mmaduakolam</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Bio-Flavonoids and Garcinoic Acid from Garcinia kola Heckel Seeds with Promising Antioxidant Potentials</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Carrageenan</style></keyword><keyword><style  face="normal" font="default" size="100%">Garcinia kola</style></keyword><keyword><style  face="normal" font="default" size="100%">Paw edema</style></keyword><keyword><style  face="normal" font="default" size="100%">Wistar rats.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">56-58</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The research was carried out to investigate the anti-inflammatory effect of ethanol extract, fraction (kolaviron) and compounds (garcinoic acid, GB1 and GB2) of &lt;em&gt;Garcinia kola&lt;/em&gt; seeds. &lt;strong&gt;Materials and Method:&lt;/strong&gt; To evaluate the acute anti-inflammatory effect of extract, fraction and compounds of &lt;em&gt;G. kola&lt;/em&gt; carrageenan-induced edema model in wistar albino rats was used. &lt;strong&gt;Results:&lt;/strong&gt; Kolaviron (50 mg/kg), garcinoic acid (50 mg/kg) and the crude extract (50 mg/kg) caused 100, 83 and 74% inhibition of carrageenan-induced paw edema respectively at 6 h post administration. Indomethacin (10 mg/ kg), the reference drug induced 100% inhibition of carrageenan-induced paw oedema. While GB1 (50 mg/kg) and GB2 (50 mg/kg) was prominent at 4, 5 and 6 h post administration. &lt;strong&gt;Conclusion:&lt;/strong&gt; Results showed that the extract possessed anti-inflammatory activity, which have justified their use in Nigeria traditional medicine to treat inflammation.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">56</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Tchimene Kenne Michel&lt;sup&gt;1,3*&lt;/sup&gt;, Anaga Arua Ottoh&lt;sup&gt;2&lt;/sup&gt;, Ugwoke Christopher Emeka Chukwunonye&lt;sup&gt;3&lt;/sup&gt;, Ezugwu Christopher Obodoike&lt;sup&gt;3&lt;/sup&gt;, Okunji Christopher&lt;sup&gt;1&lt;/sup&gt; and Iwu Maurice Mmaduakolam&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;International Centre for Ethnomedicine and Drug Development, 110 Aku Road, Nsukka, Nigeria.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, UNN, Nsukka, Nigeria.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of pharmacognosy and Environmental Medicine, UNN, Nsukka, Nigeria.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Govindappa Melappa</style></author><author><style face="normal" font="default" size="100%">Ara Roshan</style></author><author><style face="normal" font="default" size="100%">Chanduri Nithi</style></author><author><style face="normal" font="default" size="100%">Thouseef Syed Mohummed</style></author><author><style face="normal" font="default" size="100%">Channabasava</style></author><author><style face="normal" font="default" size="100%">Chandrappa Chinna Poojari</style></author></authors><secondary-authors><author><style face="normal" font="default" size="100%">Yerappa Lakshmikanth Ramachandra</style></author></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical analysis and in vitro antioxidant, antimicrobial, anti-inflammatory and cytotoxicity activities of wood rotting fungi, Trametes ochracea</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals</style></keyword><keyword><style  face="normal" font="default" size="100%">Trametes ochracea</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Mar-Apr 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">136-146</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The present research was aimed to identify the metabolites in the methaolic and hexane extract of Trametes ochracea and evaluated these extracts to know their in vitro biological activities. &lt;strong&gt;Materials and methods:&lt;/strong&gt; Two solvent extracts of T. ochracea was subjected to phytochemical analysis. The two solvent extracts were subjected to in vitro biological activity viz., antioxidant, anti-inflammatory and cytoxicity assays. &lt;strong&gt;Results:&lt;/strong&gt; The methanol extract yielded important phytochemicals viz., saponins, flavonoids, alkaloids, steroids, phenols and tannins compared to hexane. The methanolic extract has shown strong antioxidant activity in all tested methods. The methanol extract was effectively inhibited the heat induced hemolysis, antilipoxygenase activity and also stabilized the membrane, avoided the membrane denaturation, proteinase and xanthine oxidase inhibition.The onion root meristametic cells were inhibited due to toxicity of methanol extract by possessing various cellular abnormalities in various stages of actively growing cells. The yeast cells were dead due to toxicity of methanol extract by possessing cell necrosis and also fragmented the cell DNA.&lt;strong&gt; Conclusion:&lt;/strong&gt; The obtained results clearly indicates that Trametes ochracea methanol extract is having potent phytochemicals, which plays important role in antioxidant, anti-inflammatory, cytotoxicity assays. The further research is needed to identify the exact mechanism is by action of one or combination of active phytochemicals.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">136</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Govindappa Melappa&lt;sup&gt;1*&lt;/sup&gt;, Ara Roshan&lt;sup&gt;1&lt;/sup&gt;, Chanduri Nithi&lt;sup&gt;1&lt;/sup&gt;, Thouseef Syed Mohummed&lt;sup&gt;1&lt;/sup&gt;, Channabasava&lt;sup&gt;1&lt;/sup&gt;, Yerappa Lakshmikanth Ramachandra&lt;sup&gt;2 &lt;/sup&gt;and Chandrappa Chinna Poojari&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt; &lt;sup&gt;1&lt;/sup&gt;Department of Biotechnology, Shridevi Institute of Engineering &amp;amp; Technology, Sira Road, Tumkur-572 106, Karnataka, India 2Department of P.G. Studies and Research in Biotechnology &amp;amp; Bioinformatics, Kuvempu University, Jnana Sahyadri, Shankaraghatta Shimoga, Karnataka -577 451, India.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Govindappa Melappa</style></author><author><style face="normal" font="default" size="100%">Ara Roshan</style></author><author><style face="normal" font="default" size="100%">Chanduri Nithi</style></author><author><style face="normal" font="default" size="100%">Thouseef Syed Mohummed</style></author><author><style face="normal" font="default" size="100%">Channabasava</style></author><author><style face="normal" font="default" size="100%">Yerappa Lakshmikanth Ramachandra</style></author><author><style face="normal" font="default" size="100%">Chandrappa Chinna Poojari</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical analysis and in vitro antioxidant, antimicrobial, anti-inflammatory and cytotoxicity activities of wood rotting fungi, Trametes ochracea</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal </style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemicals</style></keyword><keyword><style  face="normal" font="default" size="100%">Trametes ochracea</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">8th Jan, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">136-146</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The present research was aimed to identify the metabolites in the methaolic and hexane extract of Trametes ochracea and evaluated these extracts to know their &lt;em&gt;in vitro&lt;/em&gt; biological activities. Materials and methods Two solvent extracts of T.&lt;em&gt; ochracea&lt;/em&gt; was subjected to phytochemical analysis. The two solvent extracts were subjected to &lt;em&gt;in vitro&lt;/em&gt; biological activity viz., antioxidant, anti-inflammatory and cytoxicity assays. &lt;strong&gt;Results&lt;/strong&gt;: The methanol extract yielded important phytochemicals viz., saponins, flavonoids, alkaloids, steroids, phenols and tannins compared to hexane. The methanolic extract has shown strong antioxidant activity in all tested &lt;strong&gt;methods: &lt;/strong&gt;The methanol extract was effectively inhibited the heat induced hemolysis, antilipoxygenase activity and also stabilized the membrane, avoided the membrane denaturation, proteinase and xanthine oxidase inhibition.The onion root meristametic cells were inhibited due to toxicity of methanol extract by possessing various cellular abnormalities in various stages of actively growing cells. The yeast cells were dead due to toxicity of methanol extract by possessing cell necrosis and also fragmented the cell DNA. &lt;strong&gt;Conclusions:&lt;/strong&gt; The obtained results clearly indicates that Trametes ochracea methanol extract is having potent phytochemicals, which plays important role in antioxidant, anti-inflammatory, cytotoxicity assays. The further research is needed to identify the exact mechanism is by action of one or combination of active phytochemicals.&lt;/p&gt;&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt;&lt;em&gt; Trametes ochracea&lt;/em&gt;, Phytochemicals, Antioxidant, Anti-inflammatory, Cytotoxicity.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">136</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Govindappa Melappa&lt;sup&gt;1*&lt;/sup&gt;, Ara Roshan&lt;sup&gt;1&lt;/sup&gt;, Chanduri Nithi&lt;sup&gt;1&lt;/sup&gt;, Thouseef Syed Mohummed&lt;sup&gt;1&lt;/sup&gt;, Channabasava&lt;sup&gt;1&lt;/sup&gt; Chandrappa Chinna Poojari and Yerappa Lakshmikanth Ramachandra&lt;sup&gt;2 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biotechnology, Shridevi Institute of Engineering &amp;amp; Technology, Sira Road, Tumkur-572 106, Karnataka, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of P.G. Studies and Research in Biotechnology &amp;amp; Bioinformatics, Kuvempu University, Jnana Sahyadri, Shankaraghatta Shimoga, Karnataka -577 451, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kamal Hasan</style></author><author><style face="normal" font="default" size="100%">Thangavelu Lakshmi</style></author><author><style face="normal" font="default" size="100%">Thirumalai Kumaran Rathinam</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Preliminary Phytochemical Analysis and In vitro Anti-helmenthic activity of Achyranthes aspera Leaf extract</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Achyranthes aspera</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-helmenthic</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Laxative</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">397-399</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the preliminary phytochemical analysis and &lt;em&gt;in vitro&lt;/em&gt;- Antihelmenthic activity of leaf extract of &lt;em&gt;Achyranthes aspera&lt;/em&gt;.&lt;strong&gt; Background:&lt;/strong&gt; &lt;em&gt;Achyranthes aspera &lt;/em&gt;is an annual, stiff-erect herb found commonly as a weed throughout India. The leaf ethyl acetate extract showed high larvicidal activity on the tick larvae of Rhipicephalus. It strengthen the liver and kidneys, strengthening muscles, tendons and bones, anti-inflammatory, anti-toxin, urine laxative, normalize menstruation, hemostatic, ease childbirth. Chemical Ingredients includes Akirantin, glokosa, galactose, reilosa, ramnosa, and alkaloids. Hentriakontan, sapogenin, Betaine, ecdysterone, triterpenoid saponins. &lt;strong&gt;Methods:&lt;/strong&gt; Preliminary phytochemical analysis was done by adopting the method of Evans. Antihelmenthic assay is performed by standard protocol. &lt;strong&gt;Result:&lt;/strong&gt; The present study reveals the presence of few secondary metabolites and the extract exhibitspotent Antihelmenthic activity. &lt;strong&gt;Conclusion:&lt;/strong&gt; From the present study it can be concluded that &lt;em&gt;Achyranthes aspera&lt;/em&gt; leaf extract possessed marked &lt;em&gt;in vitro&lt;/em&gt; Anti helminthic effect.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">397</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Kamal Hasan&lt;sup&gt;1&lt;/sup&gt;, Thangavelu Lakshmi&lt;sup&gt;2*&lt;/sup&gt; and Thirumalai Kumaran Rathinam&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Bachelor of Dental Surgery, Saveetha Dental College, Saveetha University, Chennai, India.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Saveetha Dental College, Saveetha University, Chennai, India.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmacy, Faculty of Pharmacognosy, Sree ramachandra University, Chennai, India.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hasan S. Yusufoglu</style></author><author><style face="normal" font="default" size="100%">Aftab Alam</style></author><author><style face="normal" font="default" size="100%">Mohamad Ayman A. Salkini</style></author><author><style face="normal" font="default" size="100%">Ahmed M. Zaghloul</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Anti-inflammatory and hepatoprotective activities of methanolic extract of Anthemis scrobicularis herbs</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anthemis scrobicularis</style></keyword><keyword><style  face="normal" font="default" size="100%">Anti-inflammatory</style></keyword><keyword><style  face="normal" font="default" size="100%">Carbon tetrachloride</style></keyword><keyword><style  face="normal" font="default" size="100%">Hepatoprotective</style></keyword><keyword><style  face="normal" font="default" size="100%">Histopathology</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">8th April 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">55-61</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;The anti-inflammatory and hepatoprotective activitiesof the methanolic extract of Anthemis scrobicularis(ANS) herbs were evaluated in rats against carrageenan induced inflammation and carbon tetrachloride (CCl&lt;sub&gt;4&lt;/sub&gt;)induced hepatic injury. To evaluate the anti-inflammatory effects of ANS, twenty male rats were divided into four equal groups. Injection of 100 &amp;mu;l carrageenan in normal saline into the subplantar region of the hind paw of rats clearly induced paw edema. The volume of paw edema was attenuated following oral administration of ANS. For hepatoprotective effects, twenty five rats were equally divided into five groups.The hepatotoxicity, induced by a single dose of CCl&lt;sub&gt;4&lt;/sub&gt;, produced significant (p&amp;lt;0.001) increase of the levels of serumtransaminase, phosphatase, bilirubin and a decrease in proteins were also noticed. The oxidative stress marker such as malondialdehyde (MDA)was increased and nonprotein sulfhydryl (NP-SH) was decreased in the hepatotoxic tissues. Pre-medication of CCl&lt;sub&gt;4&lt;/sub&gt;-intoxicated rats with ANS at the doses 250 and 500 mg/kg reversed the abnormal liver diagnostic stricture. The results showed that ANS is toxicologically safe when orally administered and possess highly significant anti-inflammatory and hepatoprotective activities and the potentials usefulness of Anthemis scrobicularis in hepatic and inflammatory disease.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words&lt;/strong&gt;: Anthemis scrobicularis, Anti-inflammatory, Hepatoprotective, Carbon tetrachloride, Histopathology.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Hasan S. Yusufoglu&lt;sup&gt;1,*&lt;/sup&gt;, Aftab Alam&lt;sup&gt;1&lt;/sup&gt;, Mohamad Ayman A. Salkini&lt;sup&gt;1&lt;/sup&gt;, Ahmed M. Zaghloul&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;1, 2&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacognosy Dept. College of Pharmacy - Salman Bin Abdulaziz University, Al-Kharj, KSA&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Pharmacognosy Department, College of Pharmacy, Mansoura University, Egypt.&lt;/p&gt;</style></auth-address></record></records></xml>