<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nurul Qurrota’Ayun</style></author><author><style face="normal" font="default" size="100%">Astria Deviyani Zakaria</style></author><author><style face="normal" font="default" size="100%">Anton Bahtiar</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Preliminary of Pharmacokinetics Study of Brown Seaweed (Turbinaria decurrens Bory) Extract in Colon Cancer Model Mice Induced by AOM (Azoxymethane) and DSS (Dextran Sodium Sulphate)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Brown seaweed</style></keyword><keyword><style  face="normal" font="default" size="100%">Colon cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Fucoxanthin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2018</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/525</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">567-570.</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Colon Cancer is one of leading cancer that causes morbidity and mortality worldwide, causes 774,000 deaths. Fucoxanthin contained brown seaweed Bory) extracts showed cytotoxic activity by and study, including colon cancer. This study aims to examine the absorption profile of fucoxanthin in blood plasma on colon cancer model mice. &lt;strong&gt;Methods:&lt;/strong&gt; Mice were induced by azoxymethane (AOM) and two cycle dextran sulfate sodium (DSS). Mice were given an extract of brown seaweed Bory that contain fucoxanthin. Fucoxanthin content in blood plasma analyzed using mobile phase methanol: acetonitrile by Reversed- Phase High-Performance Liquid Chromatography (RP-HPLC) analysis. &lt;strong&gt;Results:&lt;/strong&gt; The maximum concentration of fucoxanthin in blood was at 4 hours after administration, and the plasma concentration is 2.15 nmol/L, T1/2 6.25 h, and AUC 10.75 nmol/L/h &lt;strong&gt;Conclusions:&lt;/strong&gt; The method was applied successfully in a pharmacokinetic study and the resulting oral brown seaweed bioavailability calculated.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">567</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Nurul Qurrota&amp;rsquo;Ayun, Astria Deviyani Zakaria, Anton Bahtiar &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia Depok, INDONESIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Alim Isnansetyo</style></author><author><style face="normal" font="default" size="100%">Fadilah Nor Laili Lutfia</style></author><author><style face="normal" font="default" size="100%">Muhammad Nursid</style></author><author><style face="normal" font="default" size="100%">Trijoko</style></author><author><style face="normal" font="default" size="100%">Ratna Asmah Susidarti</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxicity of Fucoidan from Three Tropical Brown Algae Against Breast and Colon Cancer Cell Lines</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Breast cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Colon cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity.</style></keyword><keyword><style  face="normal" font="default" size="100%">Fucoidan</style></keyword><keyword><style  face="normal" font="default" size="100%">Phaeophyta</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">14-20</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Fucoidan is a sulfated polysaccharide that has a wide range of bioactivities including anti-cancer. This polysaccharide commonly is extracted from marine brown seaweed. There is lack of information on the fucoidan extracted from tropical brown algae and its anti-cancer activity.&lt;strong&gt; Objectives:&lt;/strong&gt; The objectives of this study were to purify fucoidan from &lt;em&gt;Sargassum &lt;/em&gt;sp&lt;em&gt;., Turbinaria &lt;/em&gt;sp&lt;em&gt;.&lt;/em&gt; and &lt;em&gt;Padina &lt;/em&gt;sp., and to evaluate their cytotoxicity against breast cancer (MCF-7) and colon cancer cells (WiDr). &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Fucoidan extraction was conducted by using acid extraction method. Purified fucoidans were obtained by DEAE cellulose column chromatography and confirmed by HPLC and FT-IR spectrometry. The cytotoxicity was evaluated by using the MTT (3-[4,5-dimethylthiazol-2-yl] -2,5- diphenyltetrazolium bromide) assay. &lt;strong&gt;Results:&lt;/strong&gt; Fucoidan from &lt;em&gt;Sargassum&lt;/em&gt; sp. and &lt;em&gt;Turbinaria&lt;/em&gt; sp. showed low cytotoxicity with IC&lt;sub&gt;50&lt;/sub&gt; ranging between 461-663 &lt;em&gt;&amp;mu;g&lt;/em&gt;/mL. Higher cytotoxicity against MCF-7 and WiDr was showed by fucoidan from Padina sp. with IC&lt;sub&gt;50&lt;/sub&gt; of 144 and 118 &lt;em&gt;&amp;mu;g&lt;/em&gt;/mL, respectively. While its IC&lt;sub&gt;50&lt;/sub&gt; against Vero cells was 501 &lt;em&gt;&amp;mu;g&lt;/em&gt;/mL.Standard fucoidan from Fucus vesiculosus exhibited IC&lt;sub&gt;50&lt;/sub&gt; of 60, 63 and 211 &lt;em&gt;&amp;mu;g&lt;/em&gt;/mL against MCF-7, WiDr and Vero Cells, respectively. Although the IC&lt;sub&gt;50&lt;/sub&gt; was higher than that of standard fucoidan, &lt;em&gt;Padina&lt;/em&gt; sp. fucoidan showed cytotoxicity comparable with standard fucoidan at concentrations below 100 &lt;em&gt;&amp;mu;g&lt;/em&gt;/mL. &lt;b&gt;Conclusion:&lt;/b&gt; These results indicated that &lt;em&gt;Padina&lt;/em&gt; sp.fucoidan showed potential selective cytotoxicity, and promising for the development of an anti-cancer compound.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">14</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Alim Isnansetyo&lt;sup&gt;1&lt;/sup&gt;, Fadilah Nor Laili Lutfia&lt;sup&gt;2&lt;/sup&gt;, Muhammad Nursid&lt;sup&gt;3&lt;/sup&gt;, Trijoko&lt;sup&gt;4&lt;/sup&gt;, Ratna Asmah Susidarti&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Fisheries, Faculty of Agriculture, GadjahMada University, Jl. Flora, Bulaksumur, Yogyakarta, INDONESIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Study Program of Biotechnology, Post Graduate School, GadjahMada University, INDONESIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Research and Development Center for Marine and Fisheries Product Processing and Biotechnology, Ministry of Fisheries and Marine Affair, INDONESIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Faculty of Biology, GadjahMada University, Sekip Utara, Yogyakarta, INDONESIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Faculty of Pharmacy, GadjahMada University, Sekip Utara, Yogyakarta, INDONESIA.&lt;/p&gt;
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