<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kasturi Bhattacharjee</style></author><author><style face="normal" font="default" size="100%">Moumita Nath</style></author><author><style face="normal" font="default" size="100%">Yashmin Choudhury</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Berberine Mitigates Betel-Nut Induced Hepatocarcinogenesis, Enhances Chemosensitivity to Cisplatin and Reduces Cisplatin- Induced Nephrotoxicity in Mice Exposed to an Aqueous Extract of Betel Nut</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">AEBN</style></keyword><keyword><style  face="normal" font="default" size="100%">Berberine</style></keyword><keyword><style  face="normal" font="default" size="100%">Betel-Nut</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemotherapy</style></keyword><keyword><style  face="normal" font="default" size="100%">Cisplatin</style></keyword><keyword><style  face="normal" font="default" size="100%">Toxicity</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">1021-1028</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; There is a considerable correlation between the use of betel-nut (BN) as a chewing substance and the development of various malignancies. Objective: The bioactive phytocompound berberine was tested as monotherapy or in combination with cisplatin to reduce BN-induced carcinogenesis in mice. We also examined how berberine affected cisplatin-induced toxicity. &lt;strong&gt;Methods:&lt;/strong&gt; Swiss Albino mice were exposed to aqueous extract of betel-nut (AEBN) at a dose of 2 mg ml-1 in drinking water, for 16 weeks. Following this, the mice were given a combination of AEBN and berberine (10 mg kg&lt;sup&gt;-1&lt;/sup&gt;) for 8 weeks. Control mice were given drinking water without AEBN for 24 weeks. For the combination treatment, mice that had been exposed to AEBN (2 mg ml&lt;sup&gt;-1&lt;/sup&gt;) for 16 weeks were given AEBN+sodiumchloride+cisplatin (5 mg kg&lt;sup&gt;-1&lt;/sup&gt;) +berberine (10 mg kg&lt;sup&gt;-1&lt;/sup&gt;) for 2 weeks. Histopathology, oxidative stress, proliferation, apoptosis, oncogenic and tumor suppressor proteins, hepatotoxicity, and nephrotoxicity were assessed in tissues retrieved at treatment endpoints. &lt;strong&gt;Results: &lt;/strong&gt;Berberine monotherapy reduced tissue dysplasia, liver nodulation, oxidative stress, proliferation (Ki-67 and Cyclin D1) markers, Akt/mTOR signaling, and pP53 (Ser-15) levels and apoptosis in AEBN-treated mice to levels comparable to cisplatin alone. Berberine with cisplatin decreased nephrotoxicity, fur shedding, and cancer phenotype more than cisplatin alone. &lt;strong&gt;Conclusion:&lt;/strong&gt; The study results imparted a new therapeutic approach in developing more effective and less harmful cancer treatments.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1021</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kasturi Bhattacharjee, Moumita Nath, Yashmin Choudhury*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Biotechnology, Assam University, Silchar-788011, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Temin Payum</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Distribution, Ethnobotany, Pharmacognosy and Phytoconstituents of Coptis teeta Wall.: A Highly Valued and Threatened Medicinal Plant of Eastern Himalayas</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Berberine</style></keyword><keyword><style  face="normal" font="default" size="100%">Eastern Himalayas</style></keyword><keyword><style  face="normal" font="default" size="100%">Medicinal plant</style></keyword><keyword><style  face="normal" font="default" size="100%">Mishmi tribe</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytoconstituents</style></keyword><keyword><style  face="normal" font="default" size="100%">Threatened</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/378</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">s28-s34</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objectives:&amp;nbsp;&lt;/strong&gt;To study the distribution, traditional knowledge, dose and preparations, phytoconstituents, pharmacognostic characters and to correlate phytoconstituents and the claimed health benefits among the tribal people of Arunachal Pradesh if any, the present study was carried out. &lt;strong&gt;Methods:&lt;/strong&gt; Field survey and interview were used for ethnobotany and protocol given in Shah and Seth (2010), Kakote &lt;em&gt;et. al.&lt;/em&gt;,(2012) and Wallis (2011) was followed to study pharmacognostic studies while GC-MS was used in the studies of phytoconstituents. &lt;strong&gt;Results:&lt;/strong&gt; This study reports numbers of volatile and non-volatile compounds from the rhizome of &lt;em&gt;Coptis teeta&lt;/em&gt; with high percentage of berberine alkaloids. The study also reports alkaloid deposition at parenchymatous tissues and vascular tissues of rhizome. Phytoconstituents presents in the ethanolic extract of &lt;em&gt;C.teeta &lt;/em&gt;cold be related to health problems and phytoconstituents as claimed by tribal people of Arunachal Pradesh. &lt;strong&gt;Conclusion:&lt;/strong&gt; Locally called Mishmi teeta in Arunachal Pradesh, &lt;em&gt;Coptis teeta&lt;/em&gt; Wall. is a well-known medicinal plant used among Mishmi and other tribes of Arunachal Pradesh for health problems like loose motion, stomach pain, diarrhoea and malaria. This endemic and threatened medicinal plant contains numbers of biologically active compounds and need &lt;em&gt;in-situ&lt;/em&gt; as well as &lt;em&gt;ex-situ&lt;/em&gt; conservation.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">s28</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Temin Payum &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Botany, J.N. College, Pasighat, Arunachal Pradesh-791103, INDIA.&amp;nbsp;&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Mohind C. Mohan</style></author><author><style face="normal" font="default" size="100%">Anu P. Abhimannue</style></author><author><style face="normal" font="default" size="100%">Prakash Kumar B</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Identification and Characterization of Berberine in Tinospora cordifolia by Liquid Chromatography Quadrupole Time of Flight Mass Spectrometry (LC MS/MS Q-tof) and Evaluation of its anti Inflammatory Potential</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">5 Lipoxygenase</style></keyword><keyword><style  face="normal" font="default" size="100%">Berberine</style></keyword><keyword><style  face="normal" font="default" size="100%">Mass spectrometry</style></keyword><keyword><style  face="normal" font="default" size="100%">Molecular Docking.</style></keyword><keyword><style  face="normal" font="default" size="100%">Tinospora cordifolia</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2017 </style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">/files/PJ-9-3/10.5530pj.2017.3.59</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">350-355</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; &lt;em&gt;Tinospora cordifolia&lt;/em&gt; (Willd.) Miers ex Hook F and Thomas commonly called as gudduchi or amrita is a widely used plant in traditional medicinal system of Ayurveda. A UPLC MS/MS Q-tof method for the identification and characterization of berberine in &lt;em&gt;Tinospora cordifolia&lt;/em&gt; (Willd.) Miers. ex HooK.F. and Thomas. and to evaluate the anti inflammatory potential of bioactive fraction. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; The presence of berberine in &lt;em&gt;Tinospora cordifolia&lt;/em&gt; was determined by HPLC and was subsequently isolated by HPTLC. The anti inflammatory property of the fraction containing berberine was demonstrated to have an inhibitory activity on 5 lipoxygenase, an enzyme involved in inflammatory pathway and its IC&lt;sub&gt;50&lt;/sub&gt; value was obtained. The binding interactions between berberine and 5-LOX were demonstrated by docking studies. &lt;strong&gt;Result:&lt;/strong&gt; The presence of berberine in &lt;em&gt;Tinospora cordifolia&lt;/em&gt; methanolic extract was identified by HPLC and HPTLC analysis and confirmed by UPLC MS/ MS Q-tof. The fraction containing berberine inhibited 5-LOX with an IC&lt;sub&gt;50&lt;/sub&gt; of 0.041&amp;plusmn; 0.0003&amp;mu;g/mL as compared to that of NDGA (positive control) which showed an IC&lt;sub&gt;50&lt;/sub&gt; of 2.75 &amp;plusmn; 0.05 &amp;mu;g/mL. Molecular docking of berberine with 5-LOX showed a binding energy of -8.942 &amp;plusmn; 0.039665 kcal/mol and Ki of 273.16 &amp;plusmn; 3.026 nM as compared to the NDGA which has a binding energy of -7.186 &amp;plusmn; 0.170503 kcal/mol and Ki 5.604&amp;plusmn; 1.618 &amp;mu;M. &lt;strong&gt;Conclusion:&lt;/strong&gt; &lt;em&gt;Tinospora cordifolia&lt;/em&gt; can be used as a source of berberine and possible anti inflammatory activity of &lt;em&gt;Tinospora cordifolia&lt;/em&gt; may be attributed to the presence of berberine.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">350</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Mohind C. Mohan, Anu P. Abhimannue, Prakash Kumar B&lt;sup&gt;* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Inflammation Research Lab, School of Biosciences, Mahatma Gandhi University, Kerala, INDIA.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Vidya Shivram Patil</style></author><author><style face="normal" font="default" size="100%">Nutan Padmnabh Malpathak</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Micro-morphoanatomical approach for comparative analysis of Tinospora cordifolia (Willd.) Miers and its adulterant plant using SEM and Cryostat</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Berberine</style></keyword><keyword><style  face="normal" font="default" size="100%">Morpho-anatomy</style></keyword><keyword><style  face="normal" font="default" size="100%">Pergularia daemia</style></keyword><keyword><style  face="normal" font="default" size="100%">SEM study.</style></keyword><keyword><style  face="normal" font="default" size="100%">Tinospora cordifolia</style></keyword><keyword><style  face="normal" font="default" size="100%">Tinosporin</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">39-45</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Tinospora cordifolia&lt;/em&gt; (Willd.) Miers, belongs to Menispermaceae, commonly known as &amp;ldquo;Guduchi&amp;rdquo;or &amp;ldquo;Amrita&amp;rdquo; and has immense importance in Ayurvedic medicine. Several studies have been carried out on pharmacology, pharmaceutical, anticancer activity and clinical trials of &lt;em&gt;T. cordifolia&lt;/em&gt;, however not much information is available on the adulterants that are added with the genuine plant. Considerable work has been done on pharmacognosy but very few studies have been performed on the anatomy of &lt;em&gt;T. cordifolia&lt;/em&gt;. &lt;strong&gt;Objectives:&lt;/strong&gt; Comparative micro-morphoanatomical analysis of &lt;em&gt;T. cordifolia&lt;/em&gt; and &lt;em&gt;P. daemia&lt;/em&gt;, is important for quality control of fresh and dried samples of the root, stem and leaves. &lt;strong&gt;Material and Methods:&lt;/strong&gt; The plant materials of &lt;em&gt;T. cordifolia &lt;/em&gt;and &lt;em&gt;P. daemia&lt;/em&gt; were collected, and identified. Fixed sample subjected to cryostat microtomy and sections were observed under light microscope. Micromorphology were studied by light as well as scanning electron microscope. &lt;strong&gt;Results:&lt;/strong&gt; Anatomical studies are cheap and important tool for identification of the correct medicinal plant. Adulterant plant does not contain active principles like Berberine and Tinosporin nor have similar morpho-anatomical characters. Because of the similar appearance and resemblance of dried adulterant plant samples, medicinally important &lt;em&gt;T. cordifolia&lt;/em&gt; often get adulterated with other plants. SEM study revealed morpho-anatomical differences like the abundance of starch in cortical and ray parenchyma, different types of trichomes, etc. Cryostat techniques were used for sectioning and showed the presence of xylem plates with wide multicelluar rays. &lt;strong&gt;Conclusion:&lt;/strong&gt; Morphological and anatomical differences were observed in &lt;em&gt;T. cordifolia &lt;/em&gt;and &lt;em&gt;P. daemia&lt;/em&gt;. The given results showed significant differences therefore this study aims to help in accurate identification and avoid adulteration of a medicinally important plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">39</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Vidya Shivram Patil&lt;sup&gt;1&lt;/sup&gt; and Nutan Padmnabh Malpathak&lt;sup&gt;*2&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1,2&lt;/sup&gt;Department of Botany, Savitribai Phule Pune University, Ganeshkhind Road, Pune 411007, Maharashtra, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">S.Tamilselvi</style></author><author><style face="normal" font="default" size="100%">Padma Venkatasubramanian</style></author><author><style face="normal" font="default" size="100%">N.S. Vasanthi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Physico Chemical Characterization and Anti Inflammatory Activity of Stem Extracts Of Berberis aristata DC and Cosinium fenestratum Linn in Carrageenan Induced Wistar Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antiinflammation</style></keyword><keyword><style  face="normal" font="default" size="100%">Berberine</style></keyword><keyword><style  face="normal" font="default" size="100%">Berberis aristata</style></keyword><keyword><style  face="normal" font="default" size="100%">Cosinium fenestratum</style></keyword><keyword><style  face="normal" font="default" size="100%">Physico-chemical analysis</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">26th May 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">6</style></volume><pages><style face="normal" font="default" size="100%">72-77</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;An initial study on the physico-chemical properties of Berberis aristata and Cosinium fenestratum, both used as Daruharidra by the Ayurvedic drug industry, recorded all the tested parameters within the limits of Ayurvedic Pharmacopeia of India. Also, analysis of secondary metabolite of the plants was carried out focusing on the presence and quantification of berberine in the samples. Further, the potential difference in the anti-inflammatory activity of the aqueous and methanolic stem extracts of the two species was compared using carrageenan induced Wistar rats model. At a dose of 25 mg/kg, the aqueous and methanolic crude extracts of both the plant species showed significant inhibition of rat paw edema at various time intervals viz.,0, 30, 60, 120 and 240 minutes as against the control standard drug indomethacin (p&amp;lt;0.01, p&amp;lt;0.001).&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;antiinflammation, Berberine, Berberis aristata, Cosinium fenestratum, Physico-chemical analysis.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;S Tamilselvi&lt;sup&gt;1&lt;/sup&gt;, Padma Venkatasubramanian&lt;sup&gt;*2&lt;/sup&gt; and N S Vasanthi&lt;/strong&gt;&lt;sup&gt;&lt;strong&gt;1&lt;/strong&gt;&lt;/sup&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biotechnology, Bannari Amman Institute of Technology, Sathyamangalam-638452, TamilNadu, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Institute of Ayurveda and Integrative Medicine (IAIM), Bangalore -560106, Karnataka, India.&lt;/p&gt;</style></auth-address></record></records></xml>