<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ayda Cherian</style></author><author><style face="normal" font="default" size="100%">Velmurugan Vadivel</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In silico ADME and Drug-likeness Evaluation of Phytochemicals  from the Leaves of Tabernaemontana divaricata Linn.</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Apocyanceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Cell cytotoxicity studies</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">In silico study</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1136-1142</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;&lt;em&gt;Tabernaemontana divaricata&lt;/em&gt; is a traditional plant from the family of Apocynaceae, which has wider medicinal activities such brain tonic, anti-epileptic, anti-mania and anti-oxidant. The current predictive study was aimed to know pharmacokinetics and drug likeness of selected phytochemicals present in &lt;em&gt;T.divaricata &lt;/em&gt;by using online tool Swiss-ADME.&lt;strong&gt; Methods&lt;/strong&gt;: The air-dried leaves were pulverized and subjected to Soxhlet extraction and percolation using the solvents, namely, ethanol, hydroalcoholic solvent (50:50 and 70:30 ethanol: water) and water to obtain four different extracts. Aqueous extract was made through percolation. Subsequently, gas chromatography-mass spectrometry was used to analyze each extract further. All the bioactive compounds were subjected to &lt;em&gt;in silico &lt;/em&gt;ADME and drug-likeness studies and the finalized compounds were undergone cell cytotoxicity activity. &lt;strong&gt;Results:&lt;/strong&gt; All the four extracts have distinct physicochemical properties linked to the chemicals naturally present in large amounts in &lt;em&gt;T. divaricata &lt;/em&gt;leaves. The compound 4,4,7a-Trimethylhexahydro-1-benzofuran-2(3H)- one and 2-(4-methylphenyl) indolizine having good drug likeness of 4.50 and 3.50 respectively and good lipophilicity which has the log P value of 2.51 and 3.73 appropriately. IC50 values of compounds were found to be 312.1 ± 0.2μg/ml for 4,4,7a-Trimethylhexahydro-1-benzofuran-2(3H)-one and 393.7 ± 0.2μg/ ml for 2-(4-methylphenyl) indolizine.&lt;strong&gt; Conclusion:&lt;/strong&gt; Major bioactive chemicals were found in the aqueous extract and based on the calculated ADME parameters they are anticipated to serve as cytotoxic lead compounds. It is advocated that current predictive results should be authenticated by in vitro and in vivo toxicological and pharmacological assay.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1136</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ayda Cherian, Velmurugan Vadivel*&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;Department of Pharmaceutical Chemistry, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, SRM College of Pharmacy, Kattankulathur-603203, Chengalpattu District, Tamil Nadu, India.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shalini K</style></author><author><style face="normal" font="default" size="100%">Ilango K</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Preliminary Phytochemical Studies, GC-MS Analysis and In vitro Antioxidant Activity of Selected Medicinal Plants and its Polyherbal Formulation</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Macroscopical</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytochemical</style></keyword><keyword><style  face="normal" font="default" size="100%">Polyherbal formulation</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2021</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2021</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">13</style></volume><pages><style face="normal" font="default" size="100%">648-659</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Novel polyherbal formulation (PHF) is the utilization of more than one herb in the preparation of herbal medication. The thought is found in the conventional system of medicine where the variety of herbs in a specific proportion of illness. Because of synergism, polyherbalism presents a few advantages which aren’t accessible in single herbal medication. It is utilized in these medications for the treatment of numerous sicknesses including antioxidants. &lt;strong&gt;Objective: &lt;/strong&gt;To develop a phytochemical screening and GC-MS analysis of Novel Polyherbal formulation for &lt;em&gt;In vitro&lt;/em&gt; antioxidant activity. &lt;strong&gt;Materials and Methods:&lt;/strong&gt; Macroscopical, preliminary phytochemical, quantitative phytoconstituents, and In-vitro antioxidant activity of all the individual extract and polyherbal formulation was done by chemical method. Identification of phytoconstituents with the aid of Gas chromatography – Mass spectroscopy (GC-MS).&lt;strong&gt; Results:&lt;/strong&gt; Macroscopical study and physicochemical examination, for example, ash value, extractive value, loss on drying, and pH were reported to&lt;em&gt; A. racemosus, B. variegata, C. bonducella, S. asoka,&lt;/em&gt; and &lt;em&gt;S. racemosus&lt;/em&gt; and novel polyherbal formulation. Qualitative phytochemical investigation revealed the presence of alkaloids, flavonoids, gums &amp;amp; mucilage, carbohydrates, steroids, proteins &amp;amp; amino acids, fats &amp;amp; fixed oils, glycoside, phenols, and saponins. Quantitative estimation such as TAC, TFC, TGC, TSC, and TPC was showed positive results. All the individual extract and PHF were subjected to GC-MS analysis. All the individual extract and polyherbal formulation displayed strong antioxidant activity. &lt;strong&gt;Conclusions:&lt;/strong&gt; To conclude the PHF was reported that high level of bioactive contents present and strong antioxidant activity in contrast to the preferred ascorbic acid. The GC-MS uncovered the presence of bioactive compounds and these compounds are suggested to treat antibacterial, antioxidant, anti-inflammatory, and antiviral, anti-tumor, anti-proliferative activity, and antifungal activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">648</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Shalini K&lt;sup&gt;1&lt;/sup&gt;, Ilango K&lt;sup&gt;2,&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Division of Pharmacognosy and Phytochemistry, Interdisciplinary Institute of Indian System of Medicine (IIISM), SRM Institute of Science and Technology, Kattankulathur - 603 203, Chengalpattu (Dt), Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology Kattankulathur-603 203, Chengalpattu (Dt), Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Gan B Bajracharya</style></author><author><style face="normal" font="default" size="100%">Pratigya KC</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">A High Antibacterial Efficacy of Fruits of Litsea cubeba (Lour.) Pers from Nepal. GC-MS and Antioxidative Capacity Analyses</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">Brine-shrimp assay</style></keyword><keyword><style  face="normal" font="default" size="100%">DPPH assay</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Litsea oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Minimum bactericidal concentration</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">889-893</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; Biological activities of the plant materials may vary with different geographic origin. &lt;em&gt;Litsea cubeba &lt;/em&gt;fruits are consumed in Nepal as a spice ingredient and are considered to be possessed antibacterial property. &lt;strong&gt;Objectives:&lt;/strong&gt; Aims of this work are: to compare phytoconstituents present in litsea oil by GC-MS analysis, and to evaluate antibacterial and antioxidant activities of the volatile oil and the fruit extracts. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Hydrodistillation of &lt;em&gt;L. cubeba&lt;/em&gt; fruits was performed to obtain litsea oil followed by extractions with boiling methanol. Fractionations of the extract provided hexane, dichloromethane, ethyl acetate and aqueous extracts. The oil and extracts were analysed for the phytochemicals present. They were evaluated by using antibacterial susceptibility, brine-shrimp lethality and antioxidant capacity assays. &lt;strong&gt;Results:&lt;/strong&gt; All together 49 compounds (accounting 93.66%) were identified in the litsea oil by GC-MS. Monoterpenes being dominant components, the oil constituted 15.96% of citral (geranial and neral). Other major constituents were capric acid (12.44%), β-caryophyllene oxide (7.69%), linalool (5.96%), eucalyptol (5.13%) and cis- β-terpineol (4.22%). Litsea oil, hexane extract and dichloromethane extract displayed very effective antibacterial property. Ethyl acetate extract (LC&lt;sub&gt;50&lt;/sub&gt; = 21.52 μg mL‒1) and litsea oil (LC&lt;sub&gt;50&lt;/sub&gt; = 31.62 μg mL‒1) were found highly cytotoxic against brine-shrimp nauplii. Ethyl acetate (IC&lt;sub&gt;50&lt;/sub&gt; = 124.57 μg mL‒1) and dichloromethane (IC&lt;sub&gt;50&lt;/sub&gt; = 271.08 μg mL‒1) extracts displayed a modest DPPH free radical scavenging activity. &lt;strong&gt;Conclusion:&lt;/strong&gt; Phytoconstituents present in the &lt;em&gt;L. cubeba&lt;/em&gt; fruits from Nepal were analysed. Litsea oil and the extracts have displayed high antibacterial and potentially anticarcinogenic activities.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">889</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Gan B Bajracharya&lt;sup&gt;1,&lt;/sup&gt;*, Pratigya KC&lt;sup&gt;2&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Faculty of Science, Nepal Academy of Science and Technology (NAST), Khumaltar, Lalitpur, NEPAL.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Chemistry, Tri-Chandra Multiple Campus, Tribhuvan University, Kathmandu, NEPAL.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ruchi Singh</style></author><author><style face="normal" font="default" size="100%">Preeti Chaturvedi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Characterization of Rhizome, Fruit, Leaf and Callus of Rheum emodi Wall. using GC-MS</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Callus</style></keyword><keyword><style  face="normal" font="default" size="100%">Fruit</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Leaf</style></keyword><keyword><style  face="normal" font="default" size="100%">Rheum emodi</style></keyword><keyword><style  face="normal" font="default" size="100%">Rhizome</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">May 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">617-623</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Rheum emodi&lt;/em&gt; is an immensely useful medicinal herb of Himalaya having remarkable antidiabetic and anticancerous activities reported mainly from rhizomatous portion of the plant. The present study reports Gas Chromatographic- Mass spectroscopic characterization of both the conventionally used part i.e., the rhizome as well as other parts of &lt;em&gt;R. emodi&lt;/em&gt; including callus to exploit the nonconventional parts for future use. &lt;strong&gt;Objective:&lt;/strong&gt; To explore the bioactive constituents in the methanol extract of rhizome, fruit, leaf and callus of &lt;em&gt;R. emodi&lt;/em&gt;. &lt;strong&gt;Methods:&lt;/strong&gt; Phytochemical characterization of the plant extracts was performed by using GC-MS QP 2010 Plus. Various constituents were identified after matching their mass fragmentation pattern with data available in GC-MS library of National Institute of Standards Technology (NIST) and Wiley Registry of Mass Spectral Data’s, New York (Wiley). &lt;strong&gt;Results: &lt;/strong&gt;Total of 95 bioactive compounds were obtained in methanol extract of &lt;em&gt;R. emodi&lt;/em&gt; out of which rhizome, fruit, leaf and callus revealed 31, 38, 27 and 47 compounds respectively. Two anthraquinones, chrysophanol (43.97%) and physcion (3.23%) were obtained from rhizome whereas fruit possessed only physcion (4.66%). &lt;strong&gt;Conclusion:&lt;/strong&gt; The present findings characterizes and helps to supplement the chemical profile of the plant for its futuristic role in nutritional, pharmaceutical and therapeutic industries.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Short Communication</style></work-type><section><style face="normal" font="default" size="100%">617</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Ruchi Singh*, Preeti Chaturvedi &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Biological Sciences, College of Basic Sciences and Humanities (CBSH), G. B. Pant University of Agriculture and Technology, Pantnagar, Udham Singh Nagar-263145, Uttarakhand, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Rakhi Chakraborty</style></author><author><style face="normal" font="default" size="100%">Vivekananda Mandal</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">In vitro Hypoglycemic and Antioxidant Activities of Litsea cubeba (Lour.) Pers. fruits, Traditionally used to Cure Diabetes in Darjeeling Hills (India)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antidiabetic</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidative</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Litsea cubeba (Lour.) Pers</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">November 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">s119-s128</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; Fruits of &lt;em&gt;Litsea cubeba&lt;/em&gt; (Lour.) Pers. has been reported to be used traditionally in the treatment of diabetes in Darjeeling Himalayan region of India; though the hypoglycemic potential of the fruit has not been assessed till now, and the active constituents are yet to be discovered. Therefore, there is a necessity for the appraisal and characterization of the hypoglycemic properties of the fruits.&lt;strong&gt; Methods:&lt;/strong&gt; Fresh fruits were collected and sequentially extracted with solvents of gradient polarity. &lt;em&gt;In vitro&lt;/em&gt; antidiabetic activity was performed by α-amylase and α-glucosidase inhibitory assays. Free radical scavenging activity was performed by DPPH, ABTS, TPTZ (FRAP assay), NO and OH radical scavenging assays. To identify the bioactive components, GC-MS analysis was also performed. &lt;strong&gt;Result:&lt;/strong&gt; Phytochemical screening of secondary metabolites in different solvent extracts showed the presence of phenols, flavonoids, alkaloids, cardiac glycosides, tannins, saponins, and anthocyanins. Methanolic extract exhibited highest antidiabetic potential with IC50 values of 514.9 μg/ml and 1435.7 μg/ml in α-amylase and α-glucosidase inhibition assay respectively followed by ethanol extract. Significant free radical scavenging activities were also found in the alcohol extracts. GC-MS analysis revealed the presence of principle compounds like oleic acid, morin, apigenin etc. which might be responsible for hypoglycemic activity. &lt;strong&gt;Conclusion:&lt;/strong&gt; Here we report the appraisal of traditional usage of &lt;em&gt;L. cubeba&lt;/em&gt; (Lour.) Pers. fruits based on &lt;em&gt;in vitro&lt;/em&gt; antidiabetic and antioxidant assays along with GC-MS characterization of potent molecules. Our study confirms the traditional knowledge of the people of Darjeeling Hills regarding the use of the fruit of this plant in curing diabetes.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Orginal Article</style></work-type><section><style face="normal" font="default" size="100%">s119</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Rakhi Chakraborty&lt;sup&gt;1,2&lt;/sup&gt;, Vivekananda Mandal&lt;sup&gt;2,* &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Botany, A.P.C. Roy Government College, Matigara, Siliguri - 734010, West Bengal, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Plant and Microbial Physiology and Biochemistry Laboratory, Department of Botany, University of Gour Banga, Mokdumpur, Malda - 732103, West Bengal, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Fatima A. Saleh</style></author><author><style face="normal" font="default" size="100%">Nada El-Darra</style></author><author><style face="normal" font="default" size="100%">Karim Raafat</style></author><author><style face="normal" font="default" size="100%">Iman El Ghazzawi</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Phytochemical Analysis of Nigella sativa L. Utilizing GC-MS Exploring its Antimicrobial Effects against Multidrug-Resistant Bacteria</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antibacterial</style></keyword><keyword><style  face="normal" font="default" size="100%">Antioxidant</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Multidrug resistant bacteria</style></keyword><keyword><style  face="normal" font="default" size="100%">Nigella sativa</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://fulltxt.org/article/404</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">99-105</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Introduction:&lt;/strong&gt; The alarming increase in bacterial strains resistant to existing antimicrobial agents has demanded alternative strategies. Medicinal plants are now considered as an alternative treatment because of their secure choice in several diseases. Among them, &lt;em&gt;Nigella sativa&lt;/em&gt; is a promising traditional herb having rich medical background. The aim of the study is to perform phytochemical analysis of &lt;em&gt;Nigella sativa&lt;/em&gt; L. Utilizing Gas chromatographic&amp;ndash;mass spectrometric (GC/MS) exploring its antioxidant and antibacterial activity against multidrug resistant (MDR) gram-positive and gram-negative bacteria. &lt;strong&gt;Methods:&lt;/strong&gt; Total phenolic, tannin, and flavonoid content of &lt;em&gt;N. sativa&lt;/em&gt; seed extracts and its commercially available oil were determined. Their radical scavenging activity using DPPH was also tested. The antibacterial activity of &lt;em&gt;N. sativa&lt;/em&gt; seed extracts and its oil against MDR gram-positive and gram-negative bacterial strains was studied using disc diffusion test and the biofilm formation assay. GC-MS studies were also performed. &lt;strong&gt;Results:&lt;/strong&gt; Among the different preparations used,&lt;em&gt; N. sativa&lt;/em&gt; oil showed the highest antioxidant and antibacterial activity against highly resistant gram-positive bacteria with the greatest suppression of biofilm formation, which was attributed to its high bioactive contents. &lt;strong&gt;Conclusion:&lt;/strong&gt; This study indicates that &lt;em&gt;N. sativa&lt;/em&gt; extracts and its oils can be used as natural antibacterial agents to treat infections caused by multidrug resistant bacteria.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">1</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">99</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Fatima A. Saleh&lt;sup&gt;1&lt;/sup&gt;, Nada El-Darra&lt;sup&gt;2&lt;/sup&gt;, Karim Raafat&lt;sup&gt;3&lt;/sup&gt;*, Iman El Ghazzawi&lt;sup&gt;1 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Medical Laboratory Sciences, Faculty of Health Sciences, Beirut Arab University, LEBANON.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Nutrition and Dietetics, Faculty of Health Sciences, Beirut Arab University, LEBANON.&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Sciences, Faculty of Pharmacy, Beirut Arab University, LEBANON.&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Pradeep Kumar Sharma</style></author><author><style face="normal" font="default" size="100%">Vijender Singh</style></author><author><style face="normal" font="default" size="100%">Mohammed Ali</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Chemical Composition and Antimicrobial Activity of Fresh Rhizome Essential Oil of Zingiber Officinale Roscoe</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal,</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Antimicrobial activity</style></keyword><keyword><style  face="normal" font="default" size="100%">Chemical composition</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Zingiber officinale.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">185-190</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Zingiber officinale &lt;/em&gt;Roscoe (Zingiberaceae) is a rhizomatous perennial herb found in tropical Asia. It is extensively used worldwide as a spice, flavoring agent and herbal remedy for cold, throat and chest&amp;nbsp;infections and cough. The present study was carried out to analyse an essential oil from the fresh rhizomes of &lt;em&gt;Z. officinale &lt;/em&gt;of Ghaziabad region and to evaluate its antimicrobial activity. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;The fresh rhizomes were hydrodistilled to get the essential oil which was analysed by GC and GC-MS techniques. The oil was evaluated for antimicrobial activity by disc diffusion method. &lt;strong&gt;Results and Discussion: &lt;/strong&gt;The essential oil was characterized by high percentage of sesquiterpenes (66.66%), monoterpenes (17.28%) and aliphatic compounds (13.58%). The predominant sesquiterpene was zingiberene (46.71%) followed by valencene (7.61%), &amp;beta;-funebrene (3.09%) and selina-4(14),7(11)-diene (1.03%). The major monoterpenes were characterized as citronellyl &lt;em&gt;n&lt;/em&gt;-butyrate (19.34%), &amp;beta;-phellandrene (3.70%), camphene (2.59%) and &amp;alpha;-pinene (1.09%). The essential oil exhibited significant antimicrobial activity against &lt;em&gt;Bacillus subtilis, Staphylococcus aureus&lt;/em&gt;, &lt;em&gt;Escherichia&lt;/em&gt; &lt;em&gt;coli, Pseudomonas aeruginosa&lt;/em&gt;, &lt;em&gt;Candida albicans &lt;/em&gt;and &lt;em&gt;Aspergillus niger&lt;/em&gt;. &lt;strong&gt;Conclusion: &lt;/strong&gt;The essential oil mainly contained a large number of sesquiterpenes and monoterpenes and exhibited significant antimicrobial activity against pathogenic microorganisms.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">185</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Pradeep Kumar Sharma&lt;sup&gt;1&lt;/sup&gt;*, Vijender Singh&lt;sup&gt;2&lt;/sup&gt;, Mohammed Ali&lt;sup&gt;3 &lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacy, R V Northland Institute, Greater Noida, G B Nagar, U.P. 203207, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;B B S College of Pharmacy, Greater Noida, G B Nagar, U.P. 201306, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align:justify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Phytochemistry Research Laboratory, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Muniyandi Anbukkarasi</style></author><author><style face="normal" font="default" size="100%">Philip A Thomas</style></author><author><style face="normal" font="default" size="100%">Mahalingam Sundararajan</style></author><author><style face="normal" font="default" size="100%">Pitchairaj Geraldine</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Gas Chromatography - Mass Spectrometry Analysis and In vitro Antioxidant Activity of the Ethanolic Extract of the Leaves of Tabernaemontana divaricata</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">antioxidant activity</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Metal chelating activity.</style></keyword><keyword><style  face="normal" font="default" size="100%">Phytoconstituents</style></keyword><keyword><style  face="normal" font="default" size="100%">Reducing power</style></keyword><keyword><style  face="normal" font="default" size="100%">Tabernaemontana divaricata</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Oct 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">451-458</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; To identify phytoconstituents present in an ethanolic extract of the leaves of &lt;em&gt;Tabernaemontana divaricata &lt;/em&gt;and to evaluate its in-vitro antioxidant potential. &lt;strong&gt;Methods:&lt;/strong&gt; The extract was subjected to gas chromatography- mass spectrometry analysis to identify phytoconstituents, and screened for hydroxyl, superoxide and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, reducing power and metal-chelating activity as a measure of potential antioxidant activity. &lt;strong&gt;Results:&lt;/strong&gt; GC-MS analysis of the extract revealed the presence of 96 phytoconstituents, of which 17 are reported to be bioactive and 11 of these to possess antioxidant potential. When tested&lt;em&gt; in-vitro&lt;/em&gt;, the extract exhibited the most potent radical-scavenging activity at a maximum concentration of 10 mg/ml, scavenging effects of 64%, 67% and 69% and corresponding half maximal inhibitory concentration (IC&lt;sub&gt;50&lt;/sub&gt;) values of 6.7 mg/ml, 6.8 mg/ml and 6.2 mg/ml on hydroxyl, superoxide and DPPH radicals, respectively. Ascorbic acid used as a standard (10 mg/ml) showed scavenging effects of 73%, 73% and 75% and corresponding IC&lt;sub&gt;50 &lt;/sub&gt;values of 5.3 mg/ml, 5.8 mg/ml and 5.2 mg/ml, respectively, on hydroxyl, superoxide and DPPH radicals. At 10 mg/ml, the extract and an ethylenediaminetetraacetic acid standard exhibited 68% and 78%, respectively, chelation of ferrous ions; at the same concentration, the reducing power of the extract and that of a butylated hydroxytoluene standard was found to be 3.855 and 4.308, respectively.&lt;strong&gt; Conclusion:&lt;/strong&gt; These observations strongly suggest that the ethanolic extract of &lt;em&gt;T. divaricata&lt;/em&gt; leaves has potent&lt;em&gt; in-vitro&lt;/em&gt; antioxidant activity and thereby could act as a possible therapeutic agent for oxidative stressinduced pathological states.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">451</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Muniyandi Anbukkarasi&lt;sup&gt;1&lt;/sup&gt;, Philip A Thomas&lt;sup&gt;2&lt;/sup&gt;, Mahalingam Sundararajan&lt;sup&gt;1&lt;/sup&gt;, Pitchairaj Geraldine&lt;sup&gt;1*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli- 620 024, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Ocular Microbiology, Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirappalli- 620 001, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Arsia Tarnam Yakoob</style></author><author><style face="normal" font="default" size="100%">Nargis Begum Tajuddin</style></author><author><style face="normal" font="default" size="100%">Shilu Mathew</style></author><author><style face="normal" font="default" size="100%">Muhammad Ilyas Mohammed Hussain</style></author><author><style face="normal" font="default" size="100%">Ishtiaq Qadri</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Gc-Ms Analysis of Ethanolic Stem Extract of Clausena anisata (Willd.) Hook F Ex Benth</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">C. anisata</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">maceration and phytoconstituents</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">576-578</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; In the present study, the bioactive components present in the ethanol stem extract of &lt;em&gt;Clausena anisata&lt;/em&gt; was analyzed by using Gas Chromatography Mass Spectrometry analysis technique (GC-MS). &lt;em&gt;Clausena anisata&lt;/em&gt;, a medicinal plant belonging to the family &lt;em&gt;Rutaceae&lt;/em&gt;, is represented by 20 species available in India and used traditionally for the treatment of several ailments but there is a requirement to identify its phytoconstituents, its target, mode of action and treatment using plant products either alone or in combination with synthetic drugs. &lt;strong&gt;Methods:&lt;/strong&gt; &lt;em&gt;Clausena anisata&lt;/em&gt; stem was procured from Manamettupatti, a village of Pudukottai District, Tamil Nadu. The shade dried stem was powdered and extracted using ethanol by maceration method. One microlitre of the extract was subjected to GC-MS analysis to detect the presence of bioactive compounds present in the stem of &lt;em&gt;C. anisata&lt;/em&gt;.&lt;strong&gt; Results:&lt;/strong&gt;The results showed that the ethanol stem extract of &lt;em&gt;C. anisata&lt;/em&gt; contained nine bioactive compounds, of which the major one is n-hexadecanoic acid (78.54%), followed by 8-octadecenoic acid, methyl ester, [E]- (6.638%). The total number of compounds obtained was compared with National Institutes of Standard and Technology (NIST) library that contains more than 62,000 known compounds based on retention time and molecular mass. &lt;strong&gt;Conclusion: &lt;/strong&gt;In this study, nearly nine compounds have been identified from the ethanolic stem extract of &lt;em&gt;C. anisata &lt;/em&gt;using GC-MS analysis which was mainly composed of fatty acids and sterols. The GC-MS analysis is used to understand the nature of active principles present in this plant revealed that the plant can be used as a potential source of new useful drugs.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">576</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Arsia Tarnam Yakoob&lt;sup&gt;1&lt;/sup&gt;, Nargis Begum Tajuddin&lt;sup&gt;1&lt;/sup&gt;, Shilu Mathew&lt;sup&gt;1&lt;/sup&gt;, Muhammad Ilyas Mohammed Hussain&lt;sup&gt;1&lt;/sup&gt;, Ishtiaq Qadri&lt;sup&gt;2&lt;/sup&gt;* &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Biotechnology, Jamal Mohamed College (Autonomous), Trichy, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biology, Kau University, Jeddah, K.S.A.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nartunai Govindarajan</style></author><author><style face="normal" font="default" size="100%">Uma Maheswara Reddy Cheekala</style></author><author><style face="normal" font="default" size="100%">Shantha Arcot</style></author><author><style face="normal" font="default" size="100%">Susikumar Sundaramoorthy</style></author><author><style face="normal" font="default" size="100%">Ramasamy Duraisamy</style></author><author><style face="normal" font="default" size="100%">Ilavarasan Raju</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">GC-MS Analysis of n-hexane Extract of Stem Bark of Symplocos crataegoides Buch.-Ham. ex D. Don</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">n-hexane extract</style></keyword><keyword><style  face="normal" font="default" size="100%">Patikalodhra</style></keyword><keyword><style  face="normal" font="default" size="100%">Symplocos Crataegoides</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2016</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2016</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">8</style></volume><pages><style face="normal" font="default" size="100%">520-524</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Context: &lt;/strong&gt;The stem barks of the plant &lt;em&gt;Symplocos crataegoides&lt;/em&gt; Buch.-Ham. ex D. Don (syn. &lt;em&gt;Symplocos paniculata&lt;/em&gt; (Thunb.) Miq.), Fam. Symplocaceae is extensively used in Indian medicine under the names of &lt;em&gt;Lodhra/Patikalodhra.&lt;/em&gt; Mainly it is used to cure uterine complaints, vaginal and menstrual disorders. &lt;strong&gt;Aim:&lt;/strong&gt; To investigate the phytochemicals from the n-hexane extract of the stem bark of &lt;em&gt;Symplocos crataegoides &lt;/em&gt;Buch.-Ham. ex D. Don., using GC-MS analysis. &lt;strong&gt;Materials and Methods: &lt;/strong&gt;Stem bark of &lt;em&gt;S.crataegoides&lt;/em&gt; was extracted by Soxhlet extraction method using n-hexane. The extract was injected by splitless injection mode into the GC MS 5975 C Agilent equipped with a QP- 5000 (quadrupole) Gas Chromatography - Mass Spectrometer. &lt;strong&gt;Results: &lt;/strong&gt;Identification of 57 compounds from n-hexane extract. Those compounds were identified by close matches with standard MS spectra and compared with NIST - 11 and WILEY library data. Undecane (7.51%) was found as major compound followed by Isopropyl myristate, Dodecane, 1,2,4-trimethyl-benzene, Octacosane, 2-methyl-decane, 2-ethyl-1,2-dimethyl-benzene, 1,2,3,5- tetramethyl-benzene etc., other constituents were found to be in traceable quantities.&lt;strong&gt; Conclusion:&lt;/strong&gt; GC-MS analysis of &lt;em&gt;S. crataegoides&lt;/em&gt; revealed certain interesting facts of presentation of various phytoconstituents in the stem bark. The presence of various phytoconstituents contributes to the medicinal activity of the plant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">520</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Nartunai Govindarajan&lt;sup&gt;1&lt;/sup&gt;*, Uma Maheswara Reddy Cheekala&lt;sup&gt;2&lt;/sup&gt;, Shantha Arcot&lt;sup&gt;3&lt;/sup&gt;, Susikumar Sundaramoorthy&lt;sup&gt;1&lt;/sup&gt;, Ramasamy Duraisamy&lt;sup&gt;4&lt;/sup&gt;, Ilavarasan Raju&lt;sup&gt;5&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmacognosy, &amp;amp; &lt;sup&gt;5&lt;/sup&gt;Department of Pharmacology Captain Srinivasa Murthy Regional Ayurveda Drug Development Institute, CCRAS, Govt. of India, Arumbakkam, Chennai &amp;ndash; 600 106, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Pharmacology, Sri Ramachandra College of Pharmacy, Sri Ramachandra University, Porur, Chennai - 600116, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharm. Analysis, C.L.Baid Metha College of Pharmacy, Thoraipakkam, Chennai &amp;ndash; 600 097, Tamil Nadu, INDIA.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Chemistry, Govt. Arts College, Ariyalur - 621 713, Tamil Nadu, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hassan Lawal Sani</style></author><author><style face="normal" font="default" size="100%">Ibrahim Malami</style></author><author><style face="normal" font="default" size="100%">Sanusi Wara Hassan</style></author><author><style face="normal" font="default" size="100%">Alhassan Muhammad Alhassan</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of standardized stem bark extract of Mangifera indica L. in Wister rats with 2,4-dinitrophenylhydrazine-induced haemolytic anaemia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">2</style></keyword><keyword><style  face="normal" font="default" size="100%">4-dinitrophenylhydrazine</style></keyword><keyword><style  face="normal" font="default" size="100%">Anaemia</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Haemolysis Mangifera indica L.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">27th Dec, 2014</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">89-96</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The aqueous decoction of the stem back of&lt;em&gt; Mangifera indica&lt;/em&gt; L. has been traditionally used for the treatment of various illnesses among them includes anaemia.&lt;strong&gt; Aims: &lt;/strong&gt;The aim of this study was to investigate the anti-anaemic properties of the standardized stem bark extract of &lt;em&gt;M. indica&lt;/em&gt; in animals with 2,4-dinitrophenylhydrazine-induced haemolytic anaemia. &lt;strong&gt;Methods and Material:&lt;/strong&gt; An&lt;em&gt; in vivo&lt;/em&gt; animal model was used in this experiment. 2,4-dinitrophenylhydrazine was used to induce haemolysis and treatment was done with three different concentrations (25, 50, and 100 mg/kg b.wt) of the plant extract. Astifer&amp;reg; was used as a positive control. Haematological parameters such as PCV, HGb concentration, and TLC were performed to determine the present of phytoconstituents within the crude extract. &lt;strong&gt;Results:&lt;/strong&gt; PCV and HGb concentration was increased significantly (p&amp;lt;0.001) at a dose of 50 and 100 mg/kg b.wt respectively while no significant (p&amp;gt;0.05) effect was observed at a dose of 25 mg/kg b.wt. TLC was decreased significantly (p&amp;lt;0.001) at a dose 100 mg/kg b.wt when while no significant (p&amp;gt;0.05) effect was observed at a dose of 25 and 50 mg/kg b.wt respectively. GC-MS analysis revealed the presence of 15 compounds among viz: 2,2-Dimethoxybutane, N-Acetyl-Alpha-D-glucosamine, 1,2-Benzenediol, Phenol, 2,4-bis(1,1-dimethylethyl)-, Vitamin E, Pentadecanoic acid, 13-methyl-, methyl ester, 2-Ethylacridine, Benzofuran-6-ol-3-one, 2-(4ethoxycarbonyl)benzylidene-, 9-Octadecanoic acid, (E)-, 2,4,6-Cycloheptatrien-1-one, 3,5-bis-trimethylsilyl-, and Benzo[h]quinoline,2,4-dimethyl-. &lt;strong&gt;Conclusion:&lt;/strong&gt; The results of our present finding suggest the significant anti-anaemic properties of standardized stem bark extract of &lt;em&gt;Mangefera indica&lt;/em&gt; L. This finding highlights the potentials of the extract&lt;em&gt; M. indica&lt;/em&gt; in the treatment of haemolytic anaemia.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words: &lt;/strong&gt;2,4-dinitrophenylhydrazine, Anaemia, GC-MS analysis, Haemolysis &lt;em&gt;Mangifera indica&lt;/em&gt; L.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">89</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Hassan Lawal Sani&lt;sup&gt;1&lt;/sup&gt;, Ibrahim Malami&lt;sup&gt;*1&lt;/sup&gt;, Sanusi Wara Hassan&lt;sup&gt;2&lt;/sup&gt;, Alhassan Muhammad Alhassan&lt;sup&gt;3&lt;/sup&gt;, Mshelia Emmanuel Halilu&lt;sup&gt;1&lt;/sup&gt;, Aliyu Muhammad&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Department of Pharmcognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Faculty of Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Medicinal and Chemistry, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Department of Biochemistry, Faculty of Sciences, Ahmadu Bello University, Zaria, Nigeria&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Hassan Lawal Sani</style></author><author><style face="normal" font="default" size="100%">Ibrahim Malami</style></author><author><style face="normal" font="default" size="100%">Sanusi Wara Hassan</style></author><author><style face="normal" font="default" size="100%">Alhassan Muhammad Alhassan</style></author><author><style face="normal" font="default" size="100%">Mshelia Emmanuel Halilu</style></author><author><style face="normal" font="default" size="100%">Aliyu Muhammad</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Effects of standardized stem bark extract of Mangifera indica L. in wistar rats with 2,4-dinitrophenylhydrazine-induced haemolytic anaemia</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">2</style></keyword><keyword><style  face="normal" font="default" size="100%">4-dinitrophenylhydrazine</style></keyword><keyword><style  face="normal" font="default" size="100%">Anaemia</style></keyword><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Haemolysis and Mangifera indica L.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">04/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">89-96</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;The aqueous decoction of the stem back of Mangifera indica L. has been traditionally used for the treatment of various illnesses among them includes anaemia. Aims: The aim of this study was to investigate the anti-anaemic properties of standardized stem bark extract of M. indica in animals with 2,4-dinitrophenylhydrazine-induced haemolytic anaemia. &lt;strong&gt;Methods and Material:&lt;/strong&gt; An in vivo animal model was used in this experiment. 2,4-dinitrophenylhydrazine was used to induce haemolysis and treatment was done with three different concentrations (25, 50, and 100 mg/kg b.wt) of the plant extract. Astifer&amp;reg; was used as a positive control. Haematological parameters such as PCV, HGb concentration, and TLC were performed and to ascertain the level of haemolysis. GC-MS was used determine the present of phytoconstituents within the crude extract. &lt;strong&gt;Results:&lt;/strong&gt; PCV and HGb concentration increased significantly (p&amp;lt;0.001) at a dose of 50 and 100 mg/kg b.wt respectively while no significant (p&amp;gt;0.05) effect was observed at a dose of 25 mg/kg b.wt. TLC was decreased significantly (p&amp;lt;0.001) at a dose 100 mg/kg b.wt while no significant (p&amp;gt;0.05) effect was observed at a dose of 25 and 50 mg/kg b.wt respectively. GC-MS analysis revealed presence of 15 compounds viz: 2,2-Dimethoxybutane, N-Acetyl-Alpha-D-glucosamine, 1,2-Benzenediol, Phenol, 2,4-bis(1,1-dimethylethyl)-, Vitamin E, Pentadecanoic acid, 13-methyl-, methyl ester, 2-Ethylacridine, Benzofuran-6-ol-3-one, 2-(4ethoxycarbonyl)benzylidene-, 9-Octadecanoic acid, (E)-, 2,4,6-Cycloheptatrien-1-one, 3,5-bis-trimethylsilyl-, and Benzo[h]quinoline,2,4-dimethyl-. &lt;strong&gt;Conclusion: &lt;/strong&gt;The results of our present finding suggest the significant anti-anaemic properties of standardized stem bark extract of Mangefera indica L. This finding highlights the potentials of the extract and M. indica in the treatment of haemolytic anaemia.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">89</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p&gt;&lt;strong&gt;Hassan Lawal Sani&lt;sup&gt;1&lt;/sup&gt;, Ibrahim Malami&lt;sup&gt;1*&lt;/sup&gt;, Sanusi Wara Hassan&lt;sup&gt;2&lt;/sup&gt;, Alhassan Muhammad Alhassan&lt;sup&gt;3&lt;/sup&gt;, Mshelia Emmanuel Halilu&lt;sup&gt;1&lt;/sup&gt;, Aliyu Muhammad&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;br /&gt;
&lt;sup&gt;1&lt;/sup&gt;Department of Pharmcognosy and Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria&lt;br /&gt;
&lt;sup&gt;2&lt;/sup&gt;Department of Biochemistry, Faculty of Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria&lt;br /&gt;
&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Medicinal and Chemistry, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria&lt;br /&gt;
&lt;sup&gt;4&lt;/sup&gt;Department of Biochemistry, Faculty of Sciences, Ahmadu Bello University, Zaria, Nigeria&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Kiruthika Dhanraj</style></author><author><style face="normal" font="default" size="100%">Renuka Saravanan</style></author><author><style face="normal" font="default" size="100%">Sheik Abdulla Shahul Hameed</style></author><author><style face="normal" font="default" size="100%">Sivakumar Ramalingam</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Evaluation of Anticancer Potential of Vitus vinifera Seed Against Breast Cancer Cells - MDA-MB-231</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">GC-MS analysis</style></keyword><keyword><style  face="normal" font="default" size="100%">MDA-MB-231</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword><keyword><style  face="normal" font="default" size="100%">Vitus vinifera seed</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2012</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1064-1071</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The aim of the present research is to evaluate the anti-cancer effect of &lt;em&gt;Vitus vinifera &lt;/em&gt;seed on MDA-MB-231 cell line. &lt;strong&gt;Methods: &lt;/strong&gt;The &lt;em&gt;Vitus vinifera &lt;/em&gt;(Grape) seed were dried, powdered and subjected to methanol, chloroform and ethyl acetate extraction by cold maceration followed by preliminary phytochemical screening. The extracts of &lt;em&gt;Vitus vinifera &lt;/em&gt;seed were subjected to assess anti-oxidant status, anti-proliferative activity by MTT assay, GC-MS analysis and apoptotic effect by determining LDH activity on MDA-MB-231. &lt;strong&gt;Results: &lt;/strong&gt;Results indicated that methanolic extract of grape seed showed appreciable anti-oxidant and anti-cancer potential compared with other two extracts. GC-MS mass spectrum of methanolic extract of seed revealed the presence of Dotriacontane, Linoleic acid and Decanoic acid ethyl ester, 1,2,3, propenetriol, monocetate, and Dichloro methyl propane sulfone were detected. &lt;strong&gt;Conclusion: &lt;/strong&gt;The data obtained in this work could be useful as a chemical standard in checking the genuineness of this plant source. Data of the results further depicted that the selected traditional &lt;em&gt;Vitus vinifera &lt;/em&gt;seed could be used not only as a potential anti-cancer and good antioxidant.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Research Article</style></work-type><section><style face="normal" font="default" size="100%">1064</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Kiruthika Dhanraj, Renuka Saravanan, Sheik Abdulla Shahul Hameed, Sivakumar Ramalingam*&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Chemistry and Biosciences, SASTRA Deemed to be University, Srinivasa Ramanujam Centre, Kumbakonam 612001, Tamil Nadu, INDIA.&lt;/p&gt;
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