<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shenai Ashwini</style></author><author><style face="normal" font="default" size="100%">Devaraj Ezhilarasan</style></author><author><style face="normal" font="default" size="100%">Roy Anitha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Cytotoxic Effect of Caralluma fimbriata Against Human Colon Cancer Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Caralluma fimbriata</style></keyword><keyword><style  face="normal" font="default" size="100%">COLO 320 cell line</style></keyword><keyword><style  face="normal" font="default" size="100%">Colonic cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Cytotoxicity</style></keyword><keyword><style  face="normal" font="default" size="100%">MTT Assay</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2017</style></year><pub-dates><date><style  face="normal" font="default" size="100%">February 2017</style></date></pub-dates></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://phcogj.com/fulltext/301</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">9</style></volume><pages><style face="normal" font="default" size="100%">204-207</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Aim:&lt;/strong&gt; The present study was designed to examine the cytotoxic effects of ethanolic leaf extract of &lt;em&gt;Caralluma fimbriata&lt;/em&gt; in the COLO 320 cell line. &lt;strong&gt;Materials and Method:&lt;/strong&gt; The anti-proliferative effects were evaluated using the MTT assay. The COLO 320 cells were treated with different concentrations of the leaf extract of &lt;em&gt;Caralluma&lt;/em&gt; (100 &amp;ndash; 300 &amp;mu;g/ml) for 24 h. The cell viability and IC&lt;sub&gt;50&lt;/sub&gt; was calculated from the cytotoxicity. The morphology of the &lt;em&gt;Caralluma&lt;/em&gt; treated cells, control, and positive control were observed under reverse phase inverted microscope.&lt;strong&gt; Result:&lt;/strong&gt; The &lt;em&gt;C. fimbriata&lt;/em&gt; ethanolic leaf extract showed dose dependant increase in cytotoxicity in COLO 320 human colon cancer cells. The maximum cytotoxic effect was noticed with maximum dose used in this study i.e., 300 &lt;em&gt;&amp;mu;&lt;/em&gt;g with an IC&lt;sub&gt;50&lt;/sub&gt; value of 233.87 &lt;em&gt;&amp;mu;&lt;/em&gt;g. &lt;strong&gt;Conclusion:&lt;/strong&gt; The present study shows that the ethanolic leaf extract of &lt;em&gt;Caralluma fimbriata&lt;/em&gt; is capable of reducing cell proliferation by inducing cytotoxicity of COLO 320 cells.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">204</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Shenai Ashwini, Devaraj Ezhilarasan, Roy Anitha* &lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha University, Chennai-600 077, INDIA.&lt;/p&gt;</style></auth-address></record></records></xml>