<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Carla Y. Requejo-Rodríguez</style></author><author><style face="normal" font="default" size="100%">Elmer M. Roncal-Alayo</style></author><author><style face="normal" font="default" size="100%">Carmen R. Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Víctor E. Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">William A. Sagástegui-Guarniz</style></author><author><style face="normal" font="default" size="100%">William A. Sagástegui-Guarniz</style></author><author><style face="normal" font="default" size="100%">Walter E. Janampa-Castillo</style></author><author><style face="normal" font="default" size="100%">José E. Alvarez- Trujillo</style></author><author><style face="normal" font="default" size="100%">Glenda J. Vela-Urbina</style></author><author><style face="normal" font="default" size="100%">Abhel A. Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Cinthya L. Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">María E. Cotrina-León</style></author><author><style face="normal" font="default" size="100%">Julio A. Castañeda-Carranza</style></author><author><style face="normal" font="default" size="100%">Deivy Y. Dionicio-Rosado</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Juglans regia L.: Source of Bioactive Compounds with Potential Anticancer Activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Angiogenesis</style></keyword><keyword><style  face="normal" font="default" size="100%">Antitumor</style></keyword><keyword><style  face="normal" font="default" size="100%">Apoptosis</style></keyword><keyword><style  face="normal" font="default" size="100%">Cancer</style></keyword><keyword><style  face="normal" font="default" size="100%">Juglans regia L.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">October 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">998-1003</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Juglans regia&lt;/em&gt; L., commonly known as “walnut”, belongs to the Juglandaceae family, with antioxidant, anti-inflammatory, and hypoglycemic medicinal properties. &lt;strong&gt;Objective:&lt;/strong&gt; Describe the anticancer potential of the bioactive compounds present in &lt;em&gt;Juglans regia&lt;/em&gt; L.&lt;strong&gt; Method:&lt;/strong&gt; Recent scientific studies were reviewed on the effects of bioactive compounds from &lt;em&gt;Juglans regia&lt;/em&gt; L. on inhibiting tumor growth and cancer development in several experimental models. To do this, a scientific literature search was carried out, using databases such as PubMed, Scopus, and Science Direct. &lt;strong&gt;Results:&lt;/strong&gt; Regarding the selected articles, it was found that some bioactive compounds from&lt;em&gt; Juglans regia &lt;/em&gt;L. exhibit mechanisms of anticancer action, among which the following stand out: induction of apoptosis, suppression of angiogenesis, and modulation of cell signaling pathways related to cell proliferation and survival. &lt;strong&gt;Conclusion: &lt;/strong&gt;It is concluded that &lt;em&gt;Juglans regia&lt;/em&gt; L. contains active metabolites with potential anticancer effects.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">998</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Carla Y. Requejo-Rodríguez¹, Elmer M. Roncal-Alayo¹, Carmen R. Silva-Correa&lt;sup&gt;2,*&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;2&lt;/sup&gt;, William A. Sagástegui-Guarniz&lt;sup&gt;2&lt;/sup&gt;, César D. Gamarra-Sánchez&lt;sup&gt;2&lt;/sup&gt;, Walter E. Janampa-Castillo&lt;sup&gt;3&lt;/sup&gt;, José E. Alvarez-Trujillo&lt;sup&gt;3&lt;/sup&gt;, Glenda J. Vela-Urbina&lt;sup&gt;3&lt;/sup&gt;, Abhel A. Calderón- Peña&lt;sup&gt;4&lt;/sup&gt;, Cinthya L. Aspajo- Villalaz&lt;sup&gt;4&lt;/sup&gt;, María E. Cotrina-León&lt;sup&gt;5&lt;/sup&gt;, Julio A. Castañeda-Carranza&lt;sup&gt;5&lt;/sup&gt;, Deivy Y. Dionicio-Rosado&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Escuela de Posgrado, Universidad Nacional de Trujillo, Perú&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, Perú&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Facultad de Educación y Ciencias de la Comunicación, Universidad Nacional de Trujillo, Perú&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, Perú.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Facultad de Ciencias Físicas y Matemáticas, Universidad Nacional de Trujillo, Perú.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;6&lt;/sup&gt;Facultad de Ciencias Sociales y Humanidades, Universidad Nacional Ciro Alegría, Perú&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Noha Abd Alkareem Younis Younis</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Job fulfilment and its related variables among pharmacy certificate holders in Jordan: A Cross-sectional Study</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Employee turnover.</style></keyword><keyword><style  face="normal" font="default" size="100%">Job satisfaction</style></keyword><keyword><style  face="normal" font="default" size="100%">Pharmacy certificate holders</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2022</style></year><pub-dates><date><style  face="normal" font="default" size="100%">January 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">14</style></volume><pages><style face="normal" font="default" size="100%">983-988</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; The feeling of contentment one has with their job is referred to as job satisfaction. The quality of health care, processes, and services are directly impacted by pharmacists' job satisfaction, which is a key factor in influencing their motivation. Nevertheless, there hasn't been much research done to evaluate the employment satisfaction of Jordanian pharmacists working in various professions and locations. This study assessed the job satisfaction level among all pharmacy certificate carriers (Doctor of pharmacy, pharmacists, clinical pharmacists, industrial pharmacists, academic pharmacists, and assistant pharmacists) in Jordan and the elements that influence their level of job satisfaction which finally affect their job performance and employee turnover.&lt;strong&gt; Methods:&lt;/strong&gt; This cross-sectional inquiry comprised Jordanian pharmacy certificate holders. Online national surveys on job satisfaction were conducted using a reputable, well-designed questionnaire. The questionnaire has 22 criteria for measuring job satisfaction. Logic regression analyses were utilized in order to examine the relationship between sociodemographic variables, work satisfaction indicators, and overall job satisfaction levels. &lt;strong&gt;Results: &lt;/strong&gt;The study received responses from 236 pharmacy certificate holders. The mean introducing age was middle age (30-39yrs) (52.6%), with the majority being females (87.5%). The overall job satisfaction level reported by participants had a mean score of 2.97, with 14.4% of them being satisfied with their jobs. Salary and a lack of promotion opportunities were found to be significantly related to overall job satisfaction (p = 0.001, p=0.011 respectively).&lt;strong&gt; Conclusion&lt;/strong&gt;: The majority of Jordanian pharmacy certificate holders were dissatisfied with their jobs. Increasing salary and advancement opportunities would increase job satisfaction among pharmacy certificate holders in the country. There is a need for effective human resource management and policy revision in the pharmacy sector in Jordan.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Research Article </style></work-type><section><style face="normal" font="default" size="100%">983</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Noha Abd Alkareem Younis Younis&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;Department of Pharmacy, Al Balqa Applied University, Aqaba University College, Aqaba, JORDAN.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sowmyashree Gangaraju</style></author><author><style face="normal" font="default" size="100%">Bhagyalakshmi Manjappa</style></author><author><style face="normal" font="default" size="100%">Girish Kesturu Subbaiah</style></author><author><style face="normal" font="default" size="100%">Kemparaju Kempaiah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Jackfruit (Artocarpus heterophyllus) seed extract exhibits fibrino(geno)lytic activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Fibrino(geno)lysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemostasis</style></keyword><keyword><style  face="normal" font="default" size="100%">Jackfruit</style></keyword><keyword><style  face="normal" font="default" size="100%">Moraceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Non-hemorrhagic</style></keyword><keyword><style  face="normal" font="default" size="100%">Serine/cysteine protease.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">09th Mar, 2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">171-177</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; The current study assesses the fibrinogen and fibrin clot hydrolyzing activities of aqueous seed extract of Jackfruit (AqSEJ).&lt;strong&gt; Methods:&lt;/strong&gt; The protein banding pattern of AqSEJ (100 &amp;mu;g) was analyzed on SDS-PAGE. The proteolytic activity of AqSEJ was confirmed by spectrophotometer and zymography experiments. Fibrinogen, fibrin and plasma protein hydrolyzing activities of AqSEJ were analyzed on SDS-PAGE under reduced conditions. Plasminogen activation and indirect hemolytic activities was analyzed using spectrophotometer. The non-toxic property of AqSEJ was tested by edema, hemorrhage in experimental mice. &lt;strong&gt;Results: &lt;/strong&gt;AqSEJ exhibited proteolytic activity and the specific activity was found to be 1.04 units/mg/min. Furthermore, AqSEJ non-specifically hydrolyzed A&amp;alpha;, followed by B&amp;beta; and &amp;gamma; chains of human fibrinogen and specifically hydrolyzed &amp;alpha; polymer and &amp;alpha; chain of partially cross linked human fibrin clot without affecting &amp;beta; chain and &amp;gamma;-&amp;gamma; dimer even up to the tested dose of 30 &amp;micro;g for the incubation period of 8 hours. Importantly, AqSEJ did not hydrolyze other plasma proteins and devoid of plasminogen activation property. The proteolytic activity of AqSEJ was completely neutralized by PMSF and IAA, while EDTA, EGTA, 1,10-Phenanthroline did not, suggesting the presence of serine and cysteine family proteases. Moreover, AqSEJ did not cause edema and hemorrhage in experimental mice up to the tested dose of 200 &amp;micro;g and nontoxic to RBC cells. &lt;strong&gt;Conclusion: &lt;/strong&gt;AqSEJ hydrolyzes fibrinogen and fibrin clot and non-toxic in nature. Hence, this work showcases the potential applications of Jack fruit seed proteases in the treatment of thrombotic disorders.&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Key words:&lt;/strong&gt; Fibrino(geno)lysis, Hemostasis, Jackfruit, Moraceae, Non-hemorrhagic, Serine/cysteine protease.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">171</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sowmyashree Gangaraju&lt;sup&gt;1&lt;/sup&gt;, Bhagyalakshmi Manjappa&lt;sup&gt;1&lt;/sup&gt;, Girish Kesturu Subbaiah&lt;sup&gt;1&lt;/sup&gt;, Kemparaju Kempaiah&lt;sup&gt;2&lt;/sup&gt;, Rangaiah Shashidhara Murthy&lt;sup&gt;3&lt;/sup&gt;, Jane Hoover Plow&lt;sup&gt;4&lt;/sup&gt;, Sebastin Santhosh Martin&lt;sup&gt;5&lt;/sup&gt;, Manohar Shinde&lt;sup&gt;1&lt;/sup&gt;, and Devaraja Sannaningaiah&lt;sup&gt;1*&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1,*&lt;/sup&gt;Department of Studies and Research in Biochemistry and Centre for Bioscience and Innovation, Tumkur University, Tumkur- 572103, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Departments of Studies in Biochemistry, University of Mysore, Manasagangothry, Mysore-570 006, India&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Sciences, Philadelphia College of Osteopathic Medicine. Atlanta, Georgia, USA&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Lerner Research Institute, Cleveland, OH&lt;/p&gt;&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE 17177, Stockhlm, Sweden&lt;/p&gt;</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Sowmyashree Gangaraju</style></author><author><style face="normal" font="default" size="100%">Bhagyalakshmi Manjappa</style></author><author><style face="normal" font="default" size="100%">Girish Kesturu Subbaiah</style></author><author><style face="normal" font="default" size="100%">Kemparaju Kempaiah</style></author><author><style face="normal" font="default" size="100%">Rangaiah Shashidharamurthy</style></author><author><style face="normal" font="default" size="100%">Jane Hoover Plow</style></author><author><style face="normal" font="default" size="100%">Sebastin Santhosh Martin</style></author><author><style face="normal" font="default" size="100%">Manohar Shinde</style></author><author><style face="normal" font="default" size="100%">Devaraja Sannaningaiah</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Jackfruit (Artocarpus heterophyllus) seed extract exhibits fibrino(geno)lytic activity</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Fibrino(geno)lysis</style></keyword><keyword><style  face="normal" font="default" size="100%">Hemostasis</style></keyword><keyword><style  face="normal" font="default" size="100%">Jackfruit</style></keyword><keyword><style  face="normal" font="default" size="100%">Moraceae</style></keyword><keyword><style  face="normal" font="default" size="100%">Non-hemorrhagic</style></keyword><keyword><style  face="normal" font="default" size="100%">Serine/cysteine protease.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2015</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2015</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">7</style></volume><pages><style face="normal" font="default" size="100%">171-177</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align:justify&quot;&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The current study assesses the fibrinogen and fibrin clot hydrolyzing activities of aqueous seed extract of Jackfruit (AqSEJ). &lt;strong&gt;Methods:&lt;/strong&gt; The protein banding pattern of AqSEJ (100 &amp;mu;g) was analyzed on SDS-PAGE. The proteolytic activity of AqSEJ was confirmed by spectrophotometer and zymography experiments. Fibrinogen, fibrin and plasma protein hydrolyzing activities of AqSEJ were analyzed on SDS-PAGE under reduced conditions. Plasminogen activation and indirect hemolytic activities was analyzed using spectrophotometer. The non-toxic property of AqSEJ was tested by edema, hemorrhage in experimental mice. &lt;strong&gt;Results:&lt;/strong&gt; AqSEJ exhibited proteolytic activity and the specific activity was found to be 1.04 units/mg/min. Furthermore, AqSEJ non-specifically hydrolyzed A&amp;alpha;, followed by B&amp;beta; and &amp;gamma; chains of human fibrinogen and specifically hydrolyzed &amp;alpha; polymer and &amp;alpha; chain of partially cross linked human fibrin clot without affecting &amp;beta; chain and &amp;gamma;-&amp;gamma; dimer even up to the tested dose of 30 &amp;micro;g for the incubation period of 8 hours. Importantly, AqSEJ did not hydrolyze other plasma proteins and devoid of plasminogen activation property. The proteolytic activity of AqSEJ was completely neutralized by PMSF and IAA, while EDTA, EGTA, 1,10-Phenanthroline did not, suggesting the presence of serine and cysteine family proteases. Moreover, AqSEJ did not cause edema and hemorrhage in experimental mice up to the tested dose of 200 &amp;micro;g and non-toxic to RBC cells. &lt;strong&gt;Conclusion:&lt;/strong&gt; AqSEJ hydrolyzes fibrinogen and fibrin clot and non-toxic in nature. Hence, this work showcases the potential applications of Jack fruit seed proteases in the treatment of thrombotic disorders.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">3</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">171</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Sowmyashree Gangaraju&lt;sup&gt;1&lt;/sup&gt;, Bhagyalakshmi Manjappa&lt;sup&gt;1&lt;/sup&gt;, Girish Kesturu Subbaiah&lt;sup&gt;1&lt;/sup&gt;, Kemparaju Kempaiah&lt;sup&gt;2&lt;/sup&gt;, Rangaiah Shashidharamurthy&lt;sup&gt;3&lt;/sup&gt;, Jane Hoover Plow&lt;sup&gt;4&lt;/sup&gt;, Sebastin Santhosh Martin&lt;sup&gt;5&lt;/sup&gt;, Manohar Shinde&lt;sup&gt;1&lt;/sup&gt;, and Devaraja Sannaningaiah&lt;sup&gt;1*&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;1,*&lt;/sup&gt;Department of Studies and Research in Biochemistry and Centre for Bioscience and Innovation, Tumkur University, Tumkur- 572103, India.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Department of Studies in Biochemistry, University of Mysore, Manasagangothry, Mysore-570 006, India.&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Department of Pharmaceutical Sciences, Philadelphia College of Osteopathic Medicine. Atlanta, Georgia, USA .&lt;/p&gt;

&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Department of Molecular Cardiology, Cleveland Clinic Lerner Research Institute, Cleveland, OH 5Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE 17177, Stockhlm, Sweden.&lt;/p&gt;
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