<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Laurente-Pachamango Katherine G</style></author><author><style face="normal" font="default" size="100%">Cruzado-Razco José L</style></author><author><style face="normal" font="default" size="100%">Silva-Correa Carmen R</style></author><author><style face="normal" font="default" size="100%">Villarreal-La Torre Víctor E</style></author><author><style face="normal" font="default" size="100%">Sagástegui-Guarniz William Antonio</style></author><author><style face="normal" font="default" size="100%">Gamarra-Sánchez César D</style></author><author><style face="normal" font="default" size="100%">Ricardo M Gomez-Arce</style></author><author><style face="normal" font="default" size="100%">Deivy Y Dionicio-Rosado</style></author><author><style face="normal" font="default" size="100%">Julio A. Castañeda-Carranza</style></author><author><style face="normal" font="default" size="100%">Calderón-Peña Abhel A</style></author><author><style face="normal" font="default" size="100%">Aspajo-Villalaz Cinthya L</style></author><author><style face="normal" font="default" size="100%">Chávez- Flores Juana E</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Wound Healing Activity of an Essential Oil-Based Cream of Origanum vulgare L. on Mice</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Cream</style></keyword><keyword><style  face="normal" font="default" size="100%">Essential oil</style></keyword><keyword><style  face="normal" font="default" size="100%">Origanum vulgare</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2024</style></year><pub-dates><date><style  face="normal" font="default" size="100%">April 2024</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">16</style></volume><pages><style face="normal" font="default" size="100%">292-295</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background and Aim:&lt;/strong&gt; The objective was to evaluate the effect of a cream based on the essential oil of Origanum vulgare on skin lesions induced in Mus musculus Balb/c.&lt;strong&gt; Materials and Methods:&lt;/strong&gt; The experimental animals were divided into four groups of 6 specimens each, in which skin lesions of approximately 1 cm in diameter were induced. Group I (Control) received no treatment, Group II (0.1% Origanum vulgare cream), Group III (0.5% Origanum vulgare cream), and Group IV (1% Origanum vulgare cream) received treatment for eight days. Skin lesions were measured on days 4 and 7. At the end of treatment, they were euthanized using sodium pentobarbital 60 m/kg v.ip. Skin samples were obtained and preserved in 10% formalin for histopathological analysis.&lt;strong&gt; Results: &lt;/strong&gt;When measuring the size of the skin lesions induced in the study groups, it was observed that in the control group, the decrease in the length of the lesions occurred on the fifth day; in group II, III, and IV, the lesions length decrease occurs on the second day. At the end of the experience, the measurements of the lesions were much smaller for the III and IV groups (0.33 and 0.41, respectively) compared to the control group (0.40 cm). On day seven, statistically significant difference was found on skin lesion measure between Group IV and the Control, with a significance level of p&amp;lt;0.05. &lt;strong&gt;Conclusion:&lt;/strong&gt; It is concluded that the 1% Origanum vulgare essential oil-based cream has a healing effect on dermal lesions induced in Mus musculus Balb/c.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">292</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Laurente-Pachamango Katherine G&lt;sup&gt;1&lt;/sup&gt;, Cruzado-Razco José L&lt;sup&gt;1&lt;/sup&gt;, Silva-Correa Carmen R&lt;sup&gt;1&lt;/sup&gt;, Villarreal-La Torre Víctor E&lt;sup&gt;1,*&lt;/sup&gt;, Sagástegui-Guarniz William Antonio&lt;sup&gt;1&lt;/sup&gt;, Gamarra-Sánchez César D&lt;sup&gt;1&lt;/sup&gt;, Ricardo M Gomez- Arce&lt;sup&gt;3&lt;/sup&gt;, Deivy Y Dionicio-Rosado&lt;sup&gt;3&lt;/sup&gt;, Julio A. Castañeda-Carranza&lt;sup&gt;3&lt;/sup&gt;, Calderón-Peña Abhel A&lt;sup&gt;2&lt;/sup&gt;, Aspajo- Villalaz Cinthya L&lt;sup&gt;2&lt;/sup&gt;, Chávez- Flores Juana E&lt;sup&gt;4&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Departamento de Farmacología, Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Departamento de Química Biológica y Fisiología Animal, Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Departamento de Estadística, Facultad de Ciencias Físicas y Matemática, Universidad Nacional de Trujillo, PERU.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Norbert Wiener, PERU.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Darmin Dina</style></author><author><style face="normal" font="default" size="100%">Nurhaedar Jafar</style></author><author><style face="normal" font="default" size="100%">Veny Hadju</style></author><author><style face="normal" font="default" size="100%">Hasnawati Amqam</style></author><author><style face="normal" font="default" size="100%">Wahiduddin</style></author><author><style face="normal" font="default" size="100%">Ridwan Amiruddin</style></author><author><style face="normal" font="default" size="100%">Anwar Mallongi</style></author><author><style face="normal" font="default" size="100%">Yulianah Sulaiman</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Why Preconception Treatment is Important? A Literature Reviews</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Fetus</style></keyword><keyword><style  face="normal" font="default" size="100%">Iron status</style></keyword><keyword><style  face="normal" font="default" size="100%">Preconception</style></keyword><keyword><style  face="normal" font="default" size="100%">Pregnancy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2023</style></year><pub-dates><date><style  face="normal" font="default" size="100%">December 2023</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">15</style></volume><pages><style face="normal" font="default" size="100%">1262-1267</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Objective:&lt;/strong&gt; Conceptional care is a concept that has been proposed to address maternal health problems and environmental risk factors during pregnancy to improve the health of both mother and fetus during pregnancy. This article provides an overview of several studies relating to preconception care that are useful for preparing for a healthy pregnancy and fetus. &lt;strong&gt;Methods: &lt;/strong&gt;This narrative review uses several sources from the Elsevier database. Key search terms such as preconception, iron status, pregnancy and fetus were used in this review. Of the 50 studies identified, 20 were eligible for inclusion in this review. &lt;strong&gt;Results:&lt;/strong&gt; Preconception care is getting an increased focus as an effective way to prevent complications during pregnancy, childbirth, and postpartum as well as preventing fetal abnormalities by estimating nutritional status in the preconception period. Preconception care is aimed at supporting the health of women before pregnancy, which is useful for improving the health of a pregnancy and preventing stunted fetal growth due to poor nutritional status in the mother. Low preconception iron status will have an impact on preconception gynecological morbidity, which will cause complications in pregnancy and cause low birth weight. &lt;strong&gt;Conclusion:&lt;/strong&gt; Preconception care when given regularly will affect the health of a pregnancy and the baby when born. Preconception care teaches women of reproductive age to minimize potential health risks from an early age so that if they have a baby, the baby is born in better health. Considering that a healthy baby is very late if it is prepared during pregnancy but must be prepared from the preconception period, that is why preconception is so important.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6s</style></issue><work-type><style face="normal" font="default" size="100%">Review Article</style></work-type><section><style face="normal" font="default" size="100%">1262</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Darmin Dina&lt;sup&gt;1,2,*&lt;/sup&gt;, Nurhaedar Jafar&lt;sup&gt;3&lt;/sup&gt; , Veny Hadju&lt;sup&gt;3&lt;/sup&gt; , Hasnawati Amqam&lt;sup&gt;4&lt;/sup&gt; , Wahiduddin&lt;sup&gt;4&lt;/sup&gt; , Ridwan Amiruddin&lt;sup&gt;5&lt;/sup&gt; , Anwar Mallongi&lt;sup&gt;5&lt;/sup&gt; , Yulianah Sulaiman&lt;sup&gt;6&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;Doctoral Program, Faculty of Public Health, Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;STIKES Bina Bangsa Majene, West Sulawesi, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;3&lt;/sup&gt;Nutrition Department Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;4&lt;/sup&gt;Environmental Health Department Hasanuddin University, INDONESIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;5&lt;/sup&gt;Epidemiology Department, Hasanuddin University, INDONESIA. 6 STIKES Bina Bangsa Majene, West Sulawesi, INDONESIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Galy P Rosas-Cruz</style></author><author><style face="normal" font="default" size="100%">Carmen R Silva-Correa</style></author><author><style face="normal" font="default" size="100%">Abhel A Calderón-Peña</style></author><author><style face="normal" font="default" size="100%">Víctor E Villarreal-La Torre</style></author><author><style face="normal" font="default" size="100%">Cinthya L Aspajo-Villalaz</style></author><author><style face="normal" font="default" size="100%">José L. Cruzado-Razco</style></author><author><style face="normal" font="default" size="100%">Jorge Del Rosario-Chávarri</style></author><author><style face="normal" font="default" size="100%">Juan C Rodríguez-Soto</style></author><author><style face="normal" font="default" size="100%">Orlando E Pretel-Sevillano</style></author><author><style face="normal" font="default" size="100%">William Antonio Sagástegui-Guarniz</style></author><author><style face="normal" font="default" size="100%">Anabel D González-Siccha</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Wound Healing Activity of an Ointment from Solanum tuberosum L. &quot;Tumbay Yellow Potato&quot; on Mus musculus Balb/c</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Histology</style></keyword><keyword><style  face="normal" font="default" size="100%">Skin</style></keyword><keyword><style  face="normal" font="default" size="100%">Solanum tuberosum</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Healing</style></keyword><keyword><style  face="normal" font="default" size="100%">Yellow potato</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">1268-1275</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Background: &lt;/strong&gt;&lt;em&gt;Solanum tuberosum &lt;/em&gt;L. is an Andean tuber that is mainly characterized by its antioxidant properties. &lt;strong&gt;Objective:&lt;/strong&gt; To evaluate the healing activity of an&lt;em&gt; S. tuberosum&lt;/em&gt;-based ointment on wounds induced in mice. Material and methods: Ethanolic extracts of peel and pulp of tubers of&lt;em&gt; S. tuberosum&lt;/em&gt; &quot;Tumbay yellow potato&quot; were prepared, which were incorporated into 1% and 2% ointment formulations. &lt;em&gt;Mus musculus &lt;/em&gt;Balb/c with induced wound were distributed in the following working groups: Group I (Negative Control), Group II (Positive Control: Neomycin, Polymyxin B and Bacitracin Ointment) and Groups III and IV (Ointment at 1 % and 2% of&lt;em&gt; S. tuberosum&lt;/em&gt; extract, respectively), daily administration of topical treatments were carried out for 07 days. Wound closure was determined during the experimentation time, then euthanized with sodium pentobarbital 60 mg/kg b.w. (i.p.) to obtain skin samples for histopathological analysis. &lt;strong&gt;Results: &lt;/strong&gt;Groups III and IV showed that better evidence of wound closure and scarring in the histopathological analysis, the greatest effect being in Group IV. &lt;strong&gt;Conclusions:&lt;/strong&gt;&lt;em&gt; S. tuberosum&lt;/em&gt; ointments show healing activity in induced wounds in mice, the most effective treatment being the 2% ointment formulation.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1268</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Galy P. Rosas-Cruz&lt;sup&gt;1&lt;/sup&gt;, Carmen R. Silva-Correa&lt;sup&gt;1&lt;/sup&gt;, Abhel A. Calderón- Peña&lt;sup&gt;2&lt;/sup&gt;, Víctor E. Villarreal-La Torre&lt;sup&gt;1,&lt;/sup&gt;*, Cinthya L. Aspajo- Villalaz&lt;sup&gt;2&lt;/sup&gt;, José L. Cruzado-Razco&lt;sup&gt;1&lt;/sup&gt;, Jorge Del Rosario-Chávarri&lt;sup&gt;2&lt;/sup&gt;, Juan Rodríguez-Soto&lt;sup&gt;2&lt;/sup&gt;, Orlando E. Pretel-Sevillano&lt;sup&gt;2&lt;/sup&gt;, William Antonio Sagástegui-Guarniz&lt;sup&gt;1&lt;/sup&gt;, Anabel D. González-Siccha&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shravan Kumar Paswan</style></author><author><style face="normal" font="default" size="100%">Sajal Srivastava</style></author><author><style face="normal" font="default" size="100%">Chandana Venkateswara Rao</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Wound Healing Activity of Ethanolic Extract of Selaginella Bryopteris on Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Flavonoid content</style></keyword><keyword><style  face="normal" font="default" size="100%">Oxidative stress</style></keyword><keyword><style  face="normal" font="default" size="100%">Selaginellabryopteris</style></keyword><keyword><style  face="normal" font="default" size="100%">total phenolic content</style></keyword><keyword><style  face="normal" font="default" size="100%">Wound Excision Model</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2020</style></year><pub-dates><date><style  face="normal" font="default" size="100%">March 2020</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">12</style></volume><pages><style face="normal" font="default" size="100%">335-341</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;The objective of the present study was to determine wound healing activity of ethanolic extract of&lt;em&gt; Selaginella bryopteris &lt;/em&gt;on rats. The whole plant of &lt;em&gt;S. bryopteris&lt;/em&gt; Linn. was collected from Andhra Pradesh, India and extraction was done using ethanol. GC-MS analysis was performed to determine active metabolites present in the extract followed by determination of total phenolic and flavonoid contents. &lt;em&gt;In vivo&lt;/em&gt; wound healing activity of ethanolic extract was evaluated using excision wound model. The extract was applied topically on animals by preparing ointment in two concentrations (5% and 10%) where soframycin (10%) was taken as positive control. Antioxidant activity of &lt;em&gt;S. bryopteris &lt;/em&gt;extract was observed by measuring oxidative enzymatic levels i.e. Superoxide dismutase (SOD), Catalase (CAT), reduced Glutathione (GSH) and lipid peroxidation (LPO) in animal tissues. Histopathological studies of excised skin were carried out after the experimental period. The contraction rate of the wound was higher and dose-dependent in rats treated with 5% and 10 % ointment of extract in comparison to untreated control group. The drug treated groups showed recovery phase and the percentage of healing was more in 10% at the end of experimental period. Results exhibited sufficient insights on the healing process with normal recovery stages and restored oxidative enzymatic levels. Histopathological findings provided additional positive results; the dermis with proliferating capillaries and skeletal muscle were replaced by cellular fibrous tissue and collagen fibers. Overall, the results showed that ethanolic extract of &lt;em&gt;S.bryopteris&lt;/em&gt; was an interesting traditional agent that possess significant wound healing activity.&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">2</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">335</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Shravan Kumar Paswan&lt;sup&gt;1,2,&lt;/sup&gt;*, Sajal Srivastava&lt;sup&gt;2&lt;/sup&gt;, Chandana Venkateswara Rao&lt;sup&gt;1&lt;/sup&gt; &lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacology Division, CSIRNational Botanical Research Institute, Lucknow-226001, Uttar Pradesh, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Amity Institute of Pharmacy, Amity University, Gomati Nagar, Lucknow- 226010, Uttar Pradesh, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Shravan Kumar Paswan</style></author><author><style face="normal" font="default" size="100%">Sajal Srivastava</style></author><author><style face="normal" font="default" size="100%">Chandana Venkateswara Rao</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Wound Healing Activity of Ethanolic Extract of Selaginella Bryopteris on Rats (Retracted)</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2019</style></year><pub-dates><date><style  face="normal" font="default" size="100%">September 2019</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">11</style></volume><pages><style face="normal" font="default" size="100%">984-990</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;This Article has been retracted due to Authors' request.&amp;nbsp;&lt;/p&gt;
</style></abstract><issue><style face="normal" font="default" size="100%">5</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">984</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p class=&quot;rtejustify&quot;&gt;&lt;strong&gt;Shravan Kumar Paswan&lt;sup&gt;1,2,&lt;/sup&gt;*, Sajal Srivastava&lt;sup&gt;2&lt;/sup&gt;, Chandana Venkateswara Rao&lt;sup&gt;1&lt;/sup&gt;&lt;/strong&gt;&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;1&lt;/sup&gt;Pharmacology Division, CSIRNational Botanical Research Institute, Lucknow-226001, Uttar Pradesh, INDIA.&lt;/p&gt;

&lt;p class=&quot;rtejustify&quot;&gt;&lt;sup&gt;2&lt;/sup&gt;Amity Institute of Pharmacy, Amity University, Gomati Nagar, Lucknow- 226010, Uttar Pradesh, INDIA.&lt;/p&gt;
</style></auth-address></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Nandkishor Ramdas Kotagale</style></author><author><style face="normal" font="default" size="100%">Ankit Kedia</style></author><author><style face="normal" font="default" size="100%">Rupali Gite</style></author><author><style face="normal" font="default" size="100%">Shubham Nilkanth Rahmatkar</style></author><author><style face="normal" font="default" size="100%">Dinesh Yugraj Gawande</style></author><author><style face="normal" font="default" size="100%">Milind Janraoji Umekar</style></author><author><style face="normal" font="default" size="100%">Brijesh Gulabrao Taksande</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Withaferin A attenuates Alcohol Abstinence Signs in Rats</style></title><secondary-title><style face="normal" font="default" size="100%">Pharmacognosy Journal</style></secondary-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Anxiety</style></keyword><keyword><style  face="normal" font="default" size="100%">Corticosterone</style></keyword><keyword><style  face="normal" font="default" size="100%">Ethanol withdrawal</style></keyword><keyword><style  face="normal" font="default" size="100%">HPA axis</style></keyword><keyword><style  face="normal" font="default" size="100%">Withaferin A.</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2018</style></year><pub-dates><date><style  face="normal" font="default" size="100%">August 2018</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">10</style></volume><pages><style face="normal" font="default" size="100%">1190-1195</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Background:&lt;/strong&gt; &lt;em&gt;Withania somnifera&lt;/em&gt; (WS) have been reported to inhibit acquisition and expression conditioned place preference, self-administration and withdrawal anxiety of psychostimulants. In the present work, we have assessed the effect of withaferin A on somatic and affective symptoms of ethanol withdrawal syndrome in rats. &lt;strong&gt;Methods:&lt;/strong&gt; Animals had given free access to ethanol uninterrupted for 21 days through liquid diet. Withaferin A (5, 10 and 20 mg/kg) was injected (ip) either during the development of ethanol dependence phase (days 15 &amp;ndash; 21 or 30 min before ethanol withdrawal assessment. Withdrawal signs characterized by changes in somatic signs were measured in the open field followed by evaluation of anxiety parameters, locomotion, and depressive behavior. &lt;strong&gt;Results:&lt;/strong&gt; Withaferin A treatment 30 min before 24 h postethanol withdrawal assessment did not alter the scores of somatic behavioral signs in ethanol abstinence animals. However, withaferin A (10 and 20 mg/kg, ip) from day 15-21 prevented the ethanol withdrawal-induced elevated scores of somatic behaviors, hyperlocomotion, depressive behavior, and anxiety. Withaferin A treatment did not influence the blood ethanol levels in dependent and withdrawn animals. However, withaferin A administration attenuated the elevated plasma corticosterone and ACTH levels in ethanol-withdrawn rats, suggesting withaferin A induced anti-stress effect and stabilization of HPA axis activity could have facilitated the inhibitory effect of withaferin A on ethanol withdrawal syndrome. &lt;strong&gt;Conclusion:&lt;/strong&gt; The finding supports further investigation of withaferin A and other bioactive components of WS in alcohol addiction.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">6</style></issue><work-type><style face="normal" font="default" size="100%">Original Article</style></work-type><section><style face="normal" font="default" size="100%">1190</style></section><auth-address><style face="normal" font="default" size="100%">&lt;p style=&quot;text-align: justify;&quot;&gt;&lt;strong&gt;Nandkishor Ramdas Kotagale, Ankit Kedia, Rupali Gite, Shubham Nilkanth Rahmatkar, Dinesh Yugraj Gawande, Milind Janraoji Umekar, Brijesh Gulabrao Taksande&lt;/strong&gt;&lt;/p&gt;
&lt;p style=&quot;text-align: justify;&quot;&gt;Department of Pharmacology, Division of Neuroscience, Shrimati Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur (M.S.), INDIA.&lt;/p&gt;</style></auth-address></record></records></xml>