Healing Capacity of Leaves Stalks Extract of Pasak Bumi (Eurycoma longifolia Jack.) on Incised Wounds of Mice Skin

Introduction: Pasak bumi is a medicinal plant commonly used as herbal medicine by Indonesian people. This study aims to examine the healing capacity of mice skin incised wounds by using pasak bumi leaves stalks ethanol extract ointment. Materials and Methods: This study used twenty-five male mice Balb/ c strains, grouped into five groups, divided into three treatment groups (ointment with 20% extract concentration, ointment with 35% extract concentration, and ointment with 50% extract concentration), a positive control group using Betadine®, and the negative the negative control group using an ointment base. The back of the mouse was slashed 1.0 cm long with a depth of 0.2 cm. Then, the wound was smeared twice a day for 21 consecutive days. Results: The application of 20%, 35%, and 50% of ointment extract had the effect of healing the incised wounds after 21 days just as Betadine^®. From the description score of the wound on the twenty-first day, it can be seen that the applied ointment with 35% of extract concentration shows the same healing capacity as Betadine^® (p> 0.05), unlike the administration of ointment base (p <0.05). Conclusions: It can be concluded that pasak bumi leaves stalks has the potential effect to heal incised wounds.