Effect of Hypnoanesthesia on Endogenous Opioids (Beta Endorphin and Enkephalin)

Background: Hypnoanesthesia is a state of anesthesia achieved through hypnosis techniques. Meanwhile, hypnosis is a condition in which the mind receives information without analyzing it. Hypnoanesthesia has been empirically utilized in surgery since the 18th century, but the mechanism remains unclear. Objective: This study aims to prove nociceptive pain relief due to hypnoanesthesia in minor surgery, with indications of changes in the serum levels of several excitatory and inhibitory neurotransmitters in the physiological mechanism of pain. Methods: The study subjects included patients with benign soft tissue tumors consisting of 40 people who were divided into 2 groups (treatment and control). The treatment group underwent minor surgery using hypnoanesthesia, while the control group underwent minor surgery using 2% lidocaine local anesthesia. Pain in both groups was measured by FPS (Face Pain Scale) and monitored by a vital sign monitor. Changes in the serum levels of glutamic acid, substance P, beta-endorphin and enkephalin neurotransmitters in both groups before and after the intervention were analyzed using ELISA. Results: There were no significant changes in serum levels of neurotransmitters, pre and post intervention in both groups, both excitatory neurotransmitters Glutamic Acid and Substance P and inhibitory neurotransmitters Beta Endorphins and Enkephalin (p > 0.05). Conclusion: Based on the results of the data analysis, it can be concluded that the empirical nociceptive pain relief occurred in patients who underwent minor surgery with hypnoanesthesia and there was no significant change in betaendorphin, enkephalin, glutamate acid, and substance P serum levels before and after hypnoanesthesia