ArticleViewAbstractPharmacognosy Journal,2023,15,3,461-466.DOI:10.5530/pj.2023.15.102Published:June 2023Type:Research ArticleEffectivity of Patch Herbal Mixture Composed of Mangosteen Peel Extract and Bacterial Cellulose for Wound HealingMarisca Evalina Gondokesumo, Yulanda Antonius, and Yuana Elly Agustin Marisca Evalina Gondokesumo1,*, Yulanda Antonius2, Yuana Elly Agustin3 1Faculty of Pharmacy, University of Surabaya, Surabaya, INDONESIA. 2Faculty of Biotechnology, University of Surabaya, Surabaya, INDONESIA. 3Departement of Chemical Engineering, Faculty of Engineering, University of Surabaya, Surabaya, INDONESIA. Abstract:Indonesia has a very abundant production of mangosteen, which places at the 14th largest mangosteen production in the world. High mangosteen production affects the amount of mangosteen peel waste. On the other hand, mangosteen peel has been identified as a rich source in health benefits and has proven to be antibacterial, antifungal, antioxidant, anti-inflammatory, antitumor, and anti-carcinogenic. Traditionally, one of the conventional medicines used in wound dressings or infection medicine. It can be a possibility for patch wound healing development, especially for diabetic ulcers with an open wound, wetness, chronic infections, and high inflammation. This research aims to innovate wound dressings (patch) that contain active compounds from mangosteen peel as herbs with many active compounds to enhance the wound healing process with low toxic side effects. The patch developed from organic material from bacterial cellulose. The research was carried out with the initial process of making patches from bacterial cellulose (BC), then adding mangosteen peel extract as patch dressing with different concentrations (0%, 1%, 2%, 5%, and 10% v/v). Furthermore, the patch was applied to the injured Wistar rat, for 15 days. The wound area was measured using Image-J. The results of measuring the wound area showed significant wound improvement every day at each dose of the mangosteen patch compared with the control group. The optimum dose that appears to be different from the control is 10% v/v mangosteen peel extract which has been able to leave 3% of the wound area on the 15th day. Keywords:Bacterial cellulose, Herbal compound, Mangosteen peel extract, Patch dressing, Wound treatment.View:PDF (930.72 KB) PDF Images Patch fabrication from bacterial cellulose (a) Bacterial cellulose pellicle: white and almost thin, (b) Patch from BC, (c) Patch with mangosteen peel extract that brownish changed color ‹ Correlation of Apo E Gene Polymorphism with Recurrent Acute Coronary Syndrome up Effects of Melissa officinalis essential oil on state and trait anxiety ›