ArticleViewAbstractPharmacognosy Journal,2017,DOI:10.5530/pj.2017.4.90Type:Original ArticleRETRACTED: Antioxidant and Anti-Hypercholesterolemic Potential of Vitis vinifera LeavesSushma Devi, and Randhir Singh Sushma Devi and Randhir Singh* Department of Pharmaceutical Sciences, Maharishi Markandeshwar University, Mullana, Ambala, INDIA. Abstract:Background: Grapes (Vitis vinifera) are universally appreciated fruit for their delicacy, nutrition and accepted as functional food. The objective of the present study is to evaluate antioxidant and anti-hypercholesterolemic potential of Vitis vinifera leaves extract. Methods: Qualitative and quantitative phytochemical screening of methanolic (VVME) and aqueous (VVAE) extract was carried out to identify the phytoconstituents. Antioxidant potential was evaluated by employing in-vitro and in vivo assays. The anti-hypercholesterolemic activity was evaluated by inducing hypercholesterolemia with high cholesterol diet for 21 days in experimental animals. Results: In VVME, total tannins, total flavonoids and total phenolic contents were found to be present in major amount. Both extract has significant in-vitro and in-vivo antioxidant efficacy. Different doses i.e. 100, 200 and 400 mg/kg of VVME and VVAE significantly attenuated the lipid levels. Moreover, VVME was found to be more effective as compared to VVAE and also, effectiveness was confirmed with histological results. Conclusion: It can be concluded that antioxidant and anti-hypercholesterolemic efficacy of Vitis vinifera might be due to presence of antioxidant property and active phytoconstituents. Keywords:Antioxidant, Cholesterol Diet, Hypercholesterolemia, Total Phenolic Content Etc., Vitis viniferaView:PDF (1.98 MB) PDF Images Effect of VVME and VVAE on SGOT and SGPT level in cholesterol induced hypercholesterolemia. Values are represented as mean±SEM, n=6. In statistical analysis, p<0.05 was considered to be significant; a = vs normal control; b = vs cholesterol control; p< 0.05 = *; p< 0.01= ^; p< 0.001= #.