Phytochemical and Antioxidant Evaluation of the Flavonoids and Tannins from Synadenium grantii Hook f, (Ephorbiaceae)

Background: The methanol extract (MeE) of the aerial parts from Synadenium grantii Hook f, (Ephorbiaceae) has more Polyphenols and used to treat several diseases. Objective: The aim of this study is isolation, purification and identification of Polyphenols that showed good antioxidant activity. Materials and Methods: In the present study, purification of the MeOH-H₂O extract (70:30) from the air-dried aerial parts of S. grantii resulted by different chromatographic tools. The antioxidant activities were evaluated for the examined compounds by several methods using DPPH, Reducing power, ABTS and FRAP assays. Results: A total of 14 compounds were isolated from this plant species for the first time. The results obtained showed that all the examined compounds possess remarkable antioxidant activity through all assays especially compounds 2 and 4 where they showed the highest antioxidant activity among the other compounds and very close to the results of the standard compound BHA. Conclusion: The compounds examined have exhibited antioxidant activity with promising value as natural source antioxidant drugs.