ArticleViewAbstractPharmacognosy Journal,2021,13,2,376-382.DOI:10.5530/pj.2021.13.48Published:March 2021Type:Original ArticleCharacterization and Acute Toxicity Bioactive Compound Canning Waste of Lemuru Fish Oil as Potential ImmunomodulatorDamaiyanti DW, Sari RP, and Muwarmanti D Damaiyanti DW*, Sari R.P, Muwarmanti D Oral Biology Department, Faculty of Dentistry Universitas Hang Tuah Surabaya, INDONESIA. Abstract:Background: Poly Unsaturated Fatty Acids have beneficial effects as an immunomodulator for periodontitis therapy. Lipid studies show that fish can be a unique source of polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid. Lemuru fish (Sardinella longicep) is one of fish that abbundant in Indonesia. Purpose: This study aims to find out the characterization and acute toxicity of lemuru fish oil for using in dental treatment. Methods: characterization study was tested using capillary gas chromatography coupled method with flame ionization. Acute toxicity performed by given lemuru orally with dose 174.1-917.3mg/20g mice weight for 24 hours observation and sacrificed for histopathology, meanwhile groups 96 hours observation continued. Results: Lemuru Fish oil contains 14.5% eicosapentaenoic acid and 13,2% Docosahexaenoic Acid. Acute toxicity showed the percentage of death below 50%, however, liver structure start to show an effect on dose 355.3mg/20gr Conclusion: Lemuru Fish oil had a component Poly Unsaturated Fatty Acids an potential immunomodulator. There was no acute toxicity found and the maximum dose without changing the microscopic structure of the liver is 174.1mg / 20gr. Keywords:Docosahexaenoic acid, Eicosapentaenoic acid, Lemuru fish oil, Polyunsaturated fatty acid, ToxicityView:PDF (1.48 MB) PDF Images Graphical Abstract ‹ Immunostimulatory Activities of Pegagan Embun (Hydrocotyle sibthorpioides Lam.) in White Male Mice up Gas Chromatography-Mass Spectrometry (GC-MS) Assay of Bio- Active Compounds and Phytochemical Analyses in Three Species of Apocynaceae ›