ArticleViewAbstractPharmacognosy Journal,2023,15,2,375-383.DOI:10.5530/pj.2023.15.58Published:April 2023Type:Research ArticleComplete Blood Profile after administration of Hydrocotyle sibthorpioides Lam. extract in capsule formAfriwardi, Adrul Fauzan, Salman Umar, and Yufri Aldi Afriwardi1,*, Adrul Fauzan2, Salman Umar2 , Yufri Aldi2 1Faculty of Medicine, Universitas Andalas, Padang, West Sumatra, INDONESIA. 2Faculty of Pharmacy, Universitas Andalas, Padang, West Sumatra, INDONESIA. Abstract:Pegagan embun (Hydrocotyle sibthorpioides Lam.) has been studied as an immunostimulant, increasing macrophage cell activity and phagocytosis capacity. Based on that circumstance, the study aims to prove the immunostimulating effect by measuring the activity of Hydrocotyle sibthorpioides Lam. extract in the capsule for the complete blood profile of healthy volunteers. The number of volunteers used was twenty people, and the volunteers were divided into two groups. The first group was given a placebo capsule without Hydrocotyle sibthorpioides Lam. extract. The second group was given a capsule with Hydrocotyle sibthorpioides Lam. extract with a dose of 67 mg, which was taken once a day for three days. Blood sampling was obtained before and after taking the capsule preparation. Observation of the complete blood profile was conducted by investigating changes in blood parameters such as haemoglobin levels, number of erythrocytes, number of leukocytes, hematocrit values, number of thrombocytes and the percentage of leukocyte types (banded neutrophils, segmented neutrophils, eosinophils, basophils, monocytes, and lymphocytes). The second group given Hydrocotyle sibthorpioides Lam. extract showed a significant effect on the increase in haemoglobin levels, number of thrombocytes and hematocrit values (p<0.05). The percentage of leukocyte type values showed that lymphocytes increased significantly (p<0.05). In contrast, the segmented neutrophil increased but did not show a significant difference with the percentage of banded neutrophils, eosinophils, basophils and monocytes (p>0.05). There was a nonsignificant result in all parameters for the first group, which was administrated with a placebo capsule without Hydrocotyle sibthorpioides Lam. extract. Keywords:Banded neutrophil, Basophils, Eosinophils, erythrocytes, Haematology, Haemoglobin, Hematocrit, Hydrocotile sibthorpioides Lam., Immunostimulants, Leukocytes, Lymphocyte, Monocytes, Segmented neutrophil, Thrombocytes.View:PDF (880 KB) PDF Images Graphic average percentage of leukocyte type values in the placebo capsule containing group Saccharum lactis (SL) and the capsule group of Hydrocotyle sibthorpioides Lam. Extract. ‹ The Effect of Combination between Green Tea Extract and Curcumin Extract from Mt. Lawu on BAX, Bcl-2 and Caspase-3 in Cisplatin-Induced Rat Models up Molecular Docking and ADME Studies of Centella Asiatica as Anti Hyperuricemia ›