Description of Ciplukan Toxicity (Physalis angulata L.)

Introduction: Ciplukan (Physalis angulata L.) is a plant used by Indonesian people as traditional medicine. Drug sanitization needs to be carried out to guarantee the use and availability of scientifically safe traditional medicines. This study aims to provide information and enrich knowledge about the safety of consuming ciplukan roots and stems. Methods: This study used 8 male mice as test animals, divided randomly into 4 treatment groups, namely mice treated with a dose of 0.56 mg/20 g body weight; mice treated with a dose of 5.6 mg/20 g body weight; mice treated with 56 mg/20 g body weight; and mice treated with 560 mg/20 g body weight. Treatment was given once and then observed for 24 hours to observe the number of deaths of the test animals. Then follow-up observations were carried out in 3 days on individuals who were still alive. Results: Within 24 hours all individuals at the treatment dose of 0.56 mg/20 g body weight survived, whereas all individuals at the treatment dose of 5.6; 56; and 560 mg/20 g body weight died. The observations on individuals treated at a dose of 0.56 mg/20 g body weight showed that the animals were in good condition, with sleeping and eating activities, moving a lot, having clean and nice fur, and not showing toxic symptoms such as disturbances in physical activity, impaired balance, and refusal to eat. Conclusions: The administration of the test extract below is less or equal to 0.56 mg/20 g body weight is relatively safe.