Test of Antihyperuricemia Activity of Methanol Extract of Plantain Peel (Musa Paradisiaca Var. Sapientum) Against Caffeine- Induced Mice (Mus Musculus)

Background: Hyperuricemia occurs when serum uric acid levels rise above the normal range, typically exceeding 7.0 mg/dl for adults and 6.0 mg/dl for women. This condition can lead to various health issues, including gout, kidney stones, and renal failure. Objective: This study aims to verify the effectiveness of the methanol extract from plantain peel (Musa paradisiaca var. sapientum) in reducing uric acid levels in mice (Mus musculus) and to establish the optimal dosage for maximum efficacy. Materials and Methods: This analytical experimental research utilized a paired sample T-test Pretest-Posttest design. The mice were divided into five groups: a Negative Control of Na.CMC 0.5%, a Positive Control of allopurinol at 100 mg/kg body weight, and groups receiving plantain peel methanol extract at 100 mg/kg, 200 mg/kg, and 400 mg/kg body weight. Uric acid levels were measured initially, post-caffeine induction on day 7, and post-extract induction on day 14. Results: The study found that plantain peel methanol extract exhibited an anti-hyperuricemic effect in male mice. Among the dosages tested, 400 mg/kg body weight of the plantain peel methanol extract was the most effective in reducing uric acid levels, followed by the 200 mg/kg and 100 mg/kg doses. Conclusion: Plantain peel methanol extract is effective in reducing uric acid levels in male mice, with 400 mg/kg being the most efficacious dosage. This suggests potential for further exploration of plantain peels as a treatment for hyperuricemia.