Histological Characterization of Modified Calcite Paste as Pulpotomy Material in Partially Pulpotomized Rabbit Incisors

Background: increasing the demand for vital pulp therapy (VPT) as a minimally invasive treatment, evolving the need for bio-inspired capping material to optimize the outcome with more predictable results. Aim: is to evaluate the biological efficacy of modified calcite paste as potential material for pulpotomy in terms of pulpal inflammatory response, dentin bridge formation and morphology. Methods: 24 lower central incisors of New Zealand rabbits were used, subdivided into two groups of 12 teeth according to sacrificing time (1 and 4 weeks), in each group, six teeth were used as the control group, the pulp is traumatically exposed and partially amputated left free of capping material, and six teeth used as the experimental group, were the amputated pulp capped with Modified Calcite (MC) paste, the cavity of both groups sealed with resin modified glass ionomere cement (pulpdent, USA).animal were sacrificed and teeth were collected for histological examination. Results: At 1-week and 4-week periods respectively, both groups showed non-significant differences in inflammatory extent, a highly significant difference in calcific bridge formation (P=0.002) and dentin morphology (P=0.002). The MC group showed faster dentin bridge formation with favourable morphology according to the scoring system in both periods compared to the control group. Conclusions: MC composite is a promising novel pulpotomy material.