ArticleViewAbstractPharmacognosy Journal,2024,16,5,1069-1076.DOI:10.5530/pj.2024.16.173Published:October 2024Type:Original ArticleOverview of Cancer and Treatment Challenges: Harnessing the Anti-cancer Potential of Jasminum Sambac and its Nanoparticle FormulationsYousra.A. Nomier, Anugeetha Thacheril Mohanan, Walaa A. El-Dakroury, Dallin A. Hassan, Sermugapandian Nithya, Aamena Jabeen, Eman Merghani Ali Mohammed, Moataz B. Zewail, Gihan F. Asaad, and Zeinah Y. Abbady Yousra.A. Nomier1*, Anugeetha Thacheril Mohanan2*, Walaa A. El-Dakroury3, Dallin A. Hassan2, Sermugapandian Nithya4, Aamena Jabeen5, Eman Merghani Ali Mohammed6, Moataz B. Zewail1, Gihan F. Asaad7, Zeinah Y. Abbady8 1Pharmacology and Clinical Pharmacy Department, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, OMAN. 2Pharmacology and Toxicology Department, College of Pharmacy, Jazan University, P.O Box 114, Postal code 45142, Jazan, KINGDOM OF SAUDI ARABIA. 3Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, EGYPT. 4Department of Pharmacology, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (SRIHER) (DU), Porur, Chennai 116, INDIA. 5Pharmaceutics Department, College of Pharmacy, Jazan University, P.O Box 114, Postal code 45142, Jazan, KINGDOM OF SAUDI ARABIA. 6Clinical Practice Department, College of Pharmacy, Jazan University, P.O Box 114, Postal code 45142, Jazan, KINGDOM OF SAUDI ARABIA. 7Pharmacology Department, Medical Division, National Research Centre (ID: 60014618), Dokki, Giza, EGYPT. 8Pharmacy College, German University, Cairo, EGYPT. Abstract:Cancer research strives to discover effective treatment strategies that target tumour cells while minimising the negative effects of traditional chemotherapy. Studies conducted on plant-based leads have yielded promising therapeutic activities, prompting researchers to remain vigilant in exploring further plant-based studies. Research has shown that phytochemicals found in the roots, leaves, and flowers of Jasminum sambac (J.sambac) have demonstrated various active functions, including anti-inflammatory, antimicrobial, immunomodulatory, and anxiolytic effects. The progress made in nanoparticle drug delivery systems for cancer treatment is noteworthy as it allows for higher doses of medication to be delivered directly to cancer cells while minimising the negative impact on healthy cells. Various reports showcase the nanoparticle synthesis of J.sambac for screening multiple diseases. This review provides an overview of cancer and the challenges of available treatments while exploring the potential of J.sambac for its anticancer, cytotoxic, and antioxidant properties. Furthermore, it sheds light on the recent advances made in nanoparticle formulations of Jasminum sambac for cancer and other ailments. Disseminating these updates could encourage additional exploration into the potential anti-cancer properties of J.sambac and foster the development of nanoparticles for more effective cancer treatment. Keywords:Anti-cancer, Anti-oxidant, Cancer therapy, Cytotoxic, Jasminum Sambac, NanoparticleView:PDF (409.05 KB) PDF Images A. Flower of J.sambac. B. J.sambac plant. The main active components of the flower, stem, leaves and roots, along with their reported therapeutic effects.6 ‹ Effect of Tender Coconut Water Powder Enriched with Vitamin E in Preventing Oxidative Stress of Diabetes Male Wistar Rats up Association of Triglyceride and Glucose Index with Non-Alcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus Patients ›