ArticleViewAbstractPharmacognosy Journal,2025,17,5,608-619.DOI:10.5530/pj.2025.17.76Published:September 2025Type:Original ArticleA Review on Chemical Profile and Pharmacological Properties of Marine Sponge Tectitethya CryptaDurga Prasad Kondeti, and T. Sundarrajan Durga Prasad Kondeti1, T. Sundarrajan1* 1Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, INDIA. Abstract:Marine sponges have gained recognition as a valuable resource due to their significant pharmacological properties. The investigation of substances produced by sponges has been extensively researched to identify their pharmacological properties. Marine sponges, which are part of the phylum Porifera, are thought to be the main source of marine natural products. Sponges are multicellular organisms that have a number of pores and channels for exchanging water; the secondary metabolites they create are in turn influenced by their specific environmental circumstances. Natural products such as lipids, terpenoids, peptides, alkaloids, and steroids are abundant in the marine sponge genus Tectitethya crypta. These compounds have unique chemical structures and have shown promising biological activities, making them ideal candidates for the development of novel drugs to treat various ailments. Tectitethya crypta is a sessile filter-feeder that produces a variety of bioactive compounds, including nucleosides and other secondary metabolites. This article reviews the biology and chemistry of Tectitethya crypta and serves as an introduction to the organism. We discuss the taxonomic classification, morphology, and microenvironment of the sponge, as well as the chemical structures and biological activities of its bioactive compounds. Tectitethya crypta was the source for the development of vidarabine, ara-C, and gemcitabine, which are used to treat viruses and cancer, respectively. We discussed about how these molecules may be used to treat parasitic and infectious disorders. Keywords:Anticancer drugs, Antiviral drugs, Bioactive compounds, Marine sponges, pharmacological propertiesView:PDF (1.77 MB) PDF Images Tectitethya crypta ‹ Integrated Phytochemical Evaluation of Triphala Extract: TLC Detection and GC–MS Elucidation of Bioactive Compounds up Antioxidant and Neuroprotective Effects of Chuquiraga spinosa Less. and Baccharis genistelloides (Pers.) Lam. in a Rat Model of Transient Cerebral Ischemia-reperfusion ›