Role of Capsaicin in the Repair of Cellular Activity in Mice Liver

This study aimed to determine the capsaicin efficacy on Kupffer cell, polymorphonuclear, stellate, and fibroblast cells in mice liver induced with aflatoxin B1. A total of 20 mice were used as sample, assigned into four group i.e. (T0) administered 0,5 ml of polyethylene glycol, (T1) administered 0,5 ml of capsaicin + 0,5 ml of polyethylene glycol, (T2) administered 0,1 ml of aflatoxin B1 + 0,5 ml of polyethylene glycol, (T3) administered 0,1 ml of aflatoxin B1 + 0,5 ml of capsaicin, respectively. All treatment were done for a month then followed by liver dissection for hematoxylin eosin staining. The differential cells counted then analyzed using ANOVA and Tukey multiple comparison test (p<0,05). The cell determination showed that Kupffer cell, polymorphonuclear, stellate, and fibroblast cells decreased significantly (p<0,05) in T3 group compared to T2 group. Meanwhile, the T1 group showed similar (p>0,05) with T0 group. It can be concluded that capsaicin has a potential effect to improve cellular activity in mice liver with aflatoxin B1 toxication.