Pasuchaca (Geranium ruizii Hieron.): A Medicinal Plant of the Geraniaceae Family with Hypoglycemic Effect on Alloxan-Induced Hyperglycemia in Mice

Oscar Herrera-Calderon; Renan Dilton Hañari-Quispe; Johnny Aldo Tinco-Jayo; Josefa Bertha Pari-Olarte; Luz Josefina Chacaltana-Ramos; Eddie Loyola-Gonzales; Melva Iparraguirre-Meza; Mildred Hilda Cóndor- Privat; Beatriz Lilian Galdos-Vadillo; Jenny Mendoza-Vilcahuaman; Rossibel Juana Muñoz-de-la-Torre

Pasuchaca (Geranium ruizii Hieron.): A Medicinal Plant of the Geraniaceae Family with Hypoglycemic Effect on Alloxan-Induced Hyperglycemia in Mice

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Pharmacognosy Journal,2022,14,2,315-321.

DOI:10.5530/pj.2022.14.40

Published:April 2022

Type:Original Article

Pasuchaca (Geranium ruizii Hieron.): A Medicinal Plant of the Geraniaceae Family with Hypoglycemic Effect on Alloxan-Induced Hyperglycemia in Mice

Oscar Herrera-Calderon^1,*, Renan Dilton Hañari-Quispe², Johnny Aldo Tinco-Jayo³, Josefa Bertha Pari- Olarte⁴, Luz Josefina Chacaltana-Ramos⁴, Eddie Loyola-Gonzales⁵, Melva Iparraguirre-Meza⁶, Mildred Hilda Cóndor-Privat⁶, Beatriz Lilian Galdos-Vadillo⁶, Jenny Mendoza- Vilcahuaman⁷, Rossibel Juana Muñozde-la-Torre⁷

¹Department of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, PERU.

²Clinical Pathology Laboratory, Faculty of Veterinary Medicine and Zootechnics, Universidad Nacional del Altiplano, Puno, PERU.

³Department of Human Medicine, Faculty of Health Sciences, Universidad Nacional de San Cristóbal de Huamanga, Ayacucho, PERU.

⁴Department of Pharmaceutical Chemistry, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.

⁵Department of Pharmaceutical Sciences, Faculty of Pharmacy and Biochemistry, Universidad Nacional San Luis Gonzaga, Ica, PERU.

⁶Professional school of obstetrics, Faculty of health sciences, Universidad Peruana Los Andes, Huancayo, Junin, PERU.

⁷Academic Department of obstetrics, Faculty of Health Sciences, Universidad Nacional de Huancavelica, Huancavelica, PERU.

Abstract:

Objective: The current study aims to evaluate the hypoglycemic effect of the hydroalcoholic extract of Geranium ruizii on alloxan-induced hyperglycemia in albino mice. Material and Methods: Geranium ruizii was collected in Huancayo, Junin, Peru. A phytochemical analysis was carried out to confirm the chemical groups. In the pharmacological study, hyperglycemia was induced with alloxan at doses of 170 mg/kg in male albino mice, animals with blood sugar levels above 250 mg/dL were included in the protocol. Mice were randomized into five groups (I: Alloxan 170 mg/Kg; II, III and IV (Geranium ruizii extract: 50; 150 and 300 mg/Kg body weight); and V: glibenclamide, 5mg/Kg B.W. Results: Phytochemical analysis confirmed the presence of tannins, flavonoids, alkaloids, terpenes, saponins and phenolic compounds. It is observed that at doses of 50, 150 and 300 mg/kg reduced blood glucose at 14 days of treatment. Conclusion: The hypoglycemic effect of the hydroalcoholic extract of Geranium ruizii, administered orally in mice with alloxan-induced hyperglycemia was effective with 150 mg/Kg body weight.

Keywords:Antidiabetic drugs, Antioxidants, Geranium ruizii, Herbal therapy, Medicinal plants, Pasuchaca

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Photography of different organs of Geranium ruizii Hieron.

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Herrera-Calderon O, Hañari-Quispe RD, Tinco-Jayo JA, Pari-Olarte JB, Chacaltana-Ramos LJ, Loyola-Gonzales E, et al. Pasuchaca (Geranium ruizii Hieron.): A Medicinal Plant of the Geraniaceae Family with Hypoglycemic Effect on Alloxan-Induced Hyperglycemia in Mice. Pharmacognosy Journal. 2022;14(2):315-321.

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Pasuchaca (Geranium ruizii Hieron.): A Medicinal Plant of the Geraniaceae Family with Hypoglycemic Effect on Alloxan-Induced Hyperglycemia in Mice

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Pasuchaca (Geranium ruizii Hieron.): A Medicinal Plant of the Geraniaceae Family with Hypoglycemic Effect on Alloxan-Induced Hyperglycemia in Mice

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Pasuchaca (Geranium ruizii Hieron.): A Medicinal Plant of the Geraniaceae Family with Hypoglycemic Effect on Alloxan-Induced Hyperglycemia in Mice

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