ArticleViewAbstractPharmacognosy Journal,2019,11,3,466-468.DOI:10.5530/pj.2019.11.73Published:May 2019Type:Original ArticleEvaluation of Anti-psoriatic Potential of the Fruit Rind of Punica granatum L.Janani Jacob, Gopalan R, Lakshmanaperumalsamy P, Ramanaiah Illuri, Damaji Bhosle, Gopala Krishna Sangli, and Deepak Mundkinajeddu Janani Jacob1,2*, Gopalan R3 Lakshmanaperumalsamy P4, Ramanaiah Illuri2, Damaji Bhosle2, Gopala Krishna Sangli2, Deepak M2 1Research Scholar, Karpagam Academy of Higher Education, Coimbatore- 641021, Tamil Nadu, INDIA. 2R and D Centre, Natural Remedies Pvt. Ltd. Bangalore-560 100, Karnataka, INDIA. 3Department of Botany, Karpagam Academy of Higher Education, Coimbatore- 641021, Tamil Nadu INDIA. 4Department of Environmental Sciences, Bharathiar University, Coimbatore- 641 046, Tamil Nadu INDIA. Abstract:Background: Pomegranate (Punica granatum L.) is universally known for its therapeutic properties due to its potential bioactive compounds. However, there is no established scientific study on antipsoriatic activity of pomegranate fruit rind. The aim of the study is to evaluate the anti-psoriatic activity of the isolated compounds and the extract from the fruit rind of P. granatum. In our previous study, the isolated compounds were evaluated for antioxidant potential. In continuation to the previous investigation, the present study is taken up to evaluate the extract and compounds for in vitro anti-psoriatic activity. Methods: Chromatographic techniques were employed to isolate the compounds from the aqueous acetone extract and in vitro anti-psoriatic activity was determined by thymidine phosphorylase inhibition assay. Results: From previous phytochemical investigation, three compounds were identified as Punicalagin, 2,3(S)-hexahydroxydiphenoyl-D-glucose and Punicalin. In the present study, the extract and the compounds were evaluated for anti-psoriatic activity. The results reveal that the isolated three compounds showed inhibitory activity of 89% to 95% against thymidine phosphorylase. Aqueous acetone extract also exhibited 87% inhibition. Conclusion: Punica granatum is an ideal plant for further investigation to prove its anti-psoriatic activity. Keywords:Anti-psoriatic activity, Punica granatum, Thymidine phosphorylase inhibitionView:PDF (432.33 KB) PDF Images In vitro Thymidine phosphorylase inhibition activity of compounds and extract of fruit rind of P. granatum ‹ Cytoprotective Effect of the Eryngium foetidum "Sacha Culantro" Methanolic Leaf Extract Versus Sodium Fluoride Exposed Mice using the Micronucleus Test and the Comet Assay up Antidiabetic Potential and HPTLC Fingerprinting of Schleichera oleosa (Lour) Oken ›