Objective: Evaluating Anthelmintic activity of Ximenia americana, Hopea ponga and Vitex leucoxylon extracts by using in vitro assay. Methods: The serial exhaustive extraction was carried out with a series of solvents: chloroform, ethyl acetate, methanol, ethanol and water with increasing polarity using Soxhlet apparatus. The concentrated and dried extracts were evaluated for anthelmintic activity by employing standard in vitro method (Pheretima Posthuma model). Results: In vitro anthelmintic study shows that in case of Ximenia americana chloroform extract showed higher anthelmintic activity where as incase of Hopea ponga and Vitex leucoxylon methanol extract exhibited significant activity when compared to other solvent extracts. Conclusion: Results confirm that methanol extract of Hopea ponga exhibited highest anthelmintic activity among all tested extracts. This study provides scientific evidence that the leaves of Ximenia americana, Hopea ponga and Vitex leucoxylon have anthelmintic efficacy. However further comprehensive chemical and pharmacological investigation should be carried out to isolate the active compounds and appropriate elucidation of its mechanism of action and it helps in the development of new pharmaceuticals to treat Helminthiasis.