Background: Cordia obliqua Willd. Plant belongs to genus Cordia and family Boraginaceae. Commonly it is known as Clammy Cherry and in Hindi Lasora. Earlier very few researches were carried out to explore its medicinal importance as compared with other Cordia species. Objective: To determine maximum safe dose and explore analgesic, anti-inflammatory and antipyretic activities of Cordia obliqua leaf methanol extract. Materials and Methods: As per our previous study report, the leaf methanol extract is rich in phyto-constituents and has good antioxidant effect; so only methanol extract was studied here. The maximum safe dose of methanol extract was found by acute oral toxicity study according to OECD guidelines 423. For analgesic effect, hot plate and tail flick method, for anti-inflammatory, Carageenan induced rat paw edema and for antipyretic study, yeast induced pyrexia method were used. Results: The extract dose up to 2000mg/Kg was found safe with no any side effects. Three dose levels were tested for all activities. The medium (250 mg/Kg) and high (500 mg/Kg) dose of methanol extract was found effective in all activities when compared with standard. The result for antipyretic activity was found better than other activities. Conclusion: It can be concluded that Cordia obliqua leaf is safe and effective drug for relief of pain, fever and inflammation.