ArticleViewAbstractPharmacognosy Journal,2021,13,6,1450-1455.DOI:10.5530/pj.2021.13.184Published:November 2021Type:Research ArticleEffect of Muntingia calabura L. Leaf Extract on Blood Glucose Levels and Body Weight of Alloxan-Induced Diabetic MiceTridiganita Intan Solikhah, and Gahastanira Permata Solikhah Tridiganita Intan Solikhah1,*, Gahastanira Permata Solikhah2 1Division of Veterinary Clinic, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, INDONESIA. 2Cahaya Petclinic, Mojokerto, INDONESIA Abstract:Objective: To evaluate the effect of Muntingia calabura L. leaf extract on the blood glucose level and weight of alloxan-induced diabetic mice. Methods: The mice were injected using 150mg/kg of alloxan intraperitoneally to induce diabetes. Blood glucose level was tested before alloxan injection and 5 days after injection to confirm diabetes development. M. calabura leaf extract with 100 and 300 mg/kg and 600 μg/kg of glibenclamide was given orally for 14 days. Results: The statistical results showed a significant decrease in blood glucose level, especially on day-7 and day-14 in the M. calabura leaf extract treatment group and glibenclamide treatment group compared to the model control group. There was an increase of weight on day-7 and day-14 in the M. calabura leaf extract group and a significant decrease in weight on day-7 in the glibenclamide group compared to the model control group. Conclusion: M. calabura leaf extract had a significant antidiabetic effect that can normalize the weight of alloxan-induced diabetic mice. Keywords:Alloxan, Diabetes, Mice, Muntingia calabura leafView:PDF (595.48 KB) PDF Images Phytochemistry of the ethanolic leaf extracts of Muntingia calabura L.