Background: Morinda citrifolia (Noni) has been used widely as a complementary and alternative therapy in many countries owing to its potent antioxidant activity and proven health benefits. Traditionally, it finds used as a therapeutic remedy to various diseases as an antibacterial, antitumor, anthelminthic, analgesic, anti-inflammatory, immunostimulant. Also it has proved beneficial in conditions like gastritis, skin diseases, respiratory infections, menstrual and urinary tract disorders, fever, diabetes and venereal diseases. Objective: This review emphasizes on the phytochemical and mineral profile of the different parts of Noni plant. In addition, this review corroborates the pharmacological basis for the various health benefits, traditional and medicinal applications of Noni. Materials and Methods: All the available information of Noni were collected from electronic databases such as Academic Journals, Ethnobotany, Ethnopharmacology, Springer, PubMed, Google Scholar, Science Direct and other primary and secondary sources. Results: According to our search results pertaining to scientific literature, Morinda citrifolia is used for more than 40 types of ailments worldwide. Crude extract of various parts of plant and fruit juice are reported to contain amino acids, anthraquinones, fatty acids, flavonoids, iridoids, lignans, polysaccharides, sterols, sugars, terpenoids etc. which are therapeutically useful for a broad range of pathological conditions. Fourteen human clinical trials have validated the remarkable health benefits of Noni. Conclusion: Literatures prove that Noni is pharmacologically active and is used in different forms of cancer, viz. colon, esophageal, breast, colorectal cancers; cardiovascular diseases, diabetes, arthritis, hypertension. These properties are substantiated by the preclinical or/and clinical investigations.