ArticleViewAbstractPharmacognosy Journal,2022,14,3,536-543.DOI:10.5530/pj.2022.14.68Published:June 2022Type:Original ArticleUtilization of Secondary Metabolites in Algae Kappaphycus alvarezii as a Breast Cancer Drug with a Computational MethodAF Dibha, S Wahyuningsih, ANM Ansori, VD Kharisma, MH Widyananda, AA Parikesit, MT Sibero, RT Probojati, AAA Murtadlo, JP Trinugroho, TH Sucipto, DDR Turista, I Rosadi, ME Ullah, V Jakhmola, and R Zainul AF Dibha1, S Wahyuningsih2, ANM Ansori3, VD Kharisma4, MH Widyananda4,5, AA Parikesit6, MT Sibero7, RT Probojati4,8, AAA Murtadlo4, JP Trinugroho9, TH Sucipto10, DDR Turista11, I Rosadi12, ME Ullah13, V Jakhmola14, R Zainul15,16,* 1Department of Chemistry, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, INDONESIA. 2Faculty of Biology, Gadjah Mada University, Yogyakarta, INDONESIA. 3Professor Nidom Foundation, Surabaya, INDONESIA. 4Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, INDONESIA. 5Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, Malang, INDONESIA. 6Department of Bioinformatics, School of Life Sciences, Indonesia International Institute for Life Sciences, Jakarta, INDONESIA. 7Department of Marine Science, Faculty of Fisheries and Marine Science, Universitas Diponegoro, Semarang, INDONESIA. 8Faculty of Agriculture, Universitas Kadiri, Kediri, INDONESIA. 9Department of Life Sciences, Imperial College London, South Kensington Campus, London, UNITED KINGDOM. 10Dengue Study Group, Institute of Tropical Disease, Universitas Airlangga, Surabaya, INDONESIA. 11Biology Education Department, Faculty of Teacher Training and Education, Mulawarman University, Samarinda, INDONESIA. 12Department of Biology, Faculty of Mathematics and Natural Sciences, Mulawarman University, Samarinda, INDONESIA. 13Department of Chemistry, Mississippi State University, Mississippi State, UNITED STATES. 14Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA. 15Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, Padang, INDONESIA. 16Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, Padang, INDONESIA. Abstract:Breast cancer is one of the worst diseases that affect female people. Long-term treatment with therapy or surgery has a detrimental impact on the patient. The algae Kappaphycus alvarezii has gotten a lot of interest as a breast cancer medication because it contains chemicals that are expected to be anti-cancer. The objectives of this paper were to see how secondary metabolites in algae interact with the Nuclear Factor- kappaB protein kinase in breast cancer. The ligands and proteins were obtained from the PubChem and PDB websites, respectively. Swiss ADME was then used to assess the Pharmacokinetics and Drug likeness Properties. The last stage involved using molecular docking with PyRx and molecular dynamics to identify the interaction and visualization between the ligand and the target protein. The findings of the test revealed that the maraniol chemical had a superior binding capacity with NF kB protein kinase because it has a chromone group that controls transport efficiently in preventing breast cancer proliferation. Keywords:Breast cancer, K. alvarezii, Molecular Docking., NF kB protein kinaseView:PDF (717.93 KB) PDF Images Utilization of Secondary Metabolites in Algae Kappaphycus alvarezii as a Breast Cancer Drug with a Computational Method ‹ Subchronic Toxicity Studies of a Combined Andrographis paniculata (Burm.f.) Nees, Syzygium cumini (L) Skeels, and Caesalpinia sappan L Extract in Sprague-Dawley Rats up In silico Analysis of the Polyphenolic Metabolites of Zea mays L. "Purple Corn" on HMG-CoA Reductase ›