ArticleViewAbstractPharmacognosy Journal,2023,15,4,518-523.DOI:10.5530/pj.2023.15.112Published:August 2023Type:Original Article Hepatitis E Inhibited by Rosmarinic Acid Extract from Clove Plant (Syzygium Aromaricum) through Computational AnalysisSunadi, Saddam Al Aziz, Fadhilah Fitri, Devni Prima Sari, Muhammad Raffi Ghifari, Rismi Verawati, Nita Yessirita, Oski Illiandri, Riso Sari Mandeli, Devi Purnamasari, Putri Azhari, Rahadian Zainul, Viol Dhea Kharisma, Vikash Jakhmola, Maksim Rebezov, and ANM Ansori Sunadi1, Saddam Al Aziz2, Fadhilah Fitri3, Devni Prima Sari4, Muhammad Raffi Ghifari5, Rismi Verawati6, Nita Yessirita7, Oski Illiandri8, Riso Sari Mandeli9, Devi Purnamasari10, Putri Azhari11, Rahadian Zainul6,12,*, Viol Dhea Kharisma13,14, Vikash Jakhmola15, Maksim Rebezov16,17, ANM Ansori13,15 1Agrotechnology Study Program, Faculty of Agriculture, Universitas Tamansiswa, INDONESIA. 2Mathematics Department, Universitas Negeri Padang, Padang, INDONESIA. 3Statistics Department, Universitas Negeri Padang, Padang, INDONESIA. 4Mathematics Department, Universitas Negeri Padang, Padang, INDONESIA. 5Informatics Engineering, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA. 6Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, INDONESIA. 7Agricultural Product Technology Study Program, Faculty of Agriculture, Universitas Ekasakti, INDONESIA. 8Department of Biomedicine, Faculty of Medicine, Universitas Lambung Mangkurat, Banjarmasin, South Kalimantan, INDONESIA. 9Environmental and Policy Researcher, Environmental Science Program, Universitas Negeri Padang, INDONESIA. 10Department of Radiology, Universitas Awalbros, Pekanbaru, INDONESIA. 11Department of Agricultural Technology, Faculty of Agricultural Technology, Universitas Andalas, Padang, West Sumatra, INDONESIA. 12Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, INDONESIA. 13Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA. 14Generasi Biologi Indonesia Foundation, Gresik, INDONESIA. 15Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA. 16Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, RUSSIAN FEDERATION. 17Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIAN FEDERATION. Abstract:This study aims to evaluate the potential of Rosmarinic Acid as an inhibitor against Hepatitis E by interacting with the active site of the Tyrosine FYN protein. Computational approaches were employed to predict the molecular interactions between Rosmarinic Acid and Tyrosine FYN. The research methodology involved the use of software such as Pymol, Pyrex, Protein Plus, and the Lepinski Rule. Docking analysis was conducted using Pymol to obtain information about the binding energy between Rosmarinic Acid and Tyrosine FYN. The results of the analysis showed that Rosmarinic Acid exhibited a Binding Affinity of -8.3, -8, and -7.9, indicating a strong affinity towards the target protein. Additionally, Root Mean Square Deviation (RMSD) values of 0, 15.905, and 17.014 were used to assess the stability of the formed protein-ligand complex. Analysis using Protein Plus revealed interactions between Rosmarinic Acid and Tyrosine FYN. Furthermore, analysis using the Lepinski Rule to examine the physicochemical properties of Rosmarinic Acid indicated that the molecule had a mass of 360, 5 hydrogen bond donors, 8 hydrogen bond acceptors, a log P value of 1.76, and a molar reactivity of 89.8. These findings highlight the potential of Rosmarinic Acid as an inhibitor of Hepatitis E through its interaction with the Tyrosine FYN protein, providing a basis for the development of potential new therapies in the treatment of this disease. Keywords:Hepatitis E, Molecular Docking., Rosmarinic acid, Syzygium aromaricum, Tyrosine FYNView:PDF (736.53 KB) PDF Images Hepatitis E Inhibited by Rosmarinic Acid Extract from Clove Plant (Syzygium Aromaricum) through Computational Analysis ‹ In Silico Study of Rhamnocitrin Extract from Clove Syzygium Aromaricum in Inhibiting Adenosine A1 Adenylate Cyclase Interaction up Analysis of Lung TB Treatment Strategy in Pangkep District Year 2022 ›