ArticleViewAbstractPharmacognosy Journal,2022,14,6,771-777.DOI:10.5530/pj.2022.14.166Published:December 2022Type:Original ArticleThe Effects of Leaves Extract of Toddalia aculeata on Body Weight, Body Mass Index, Body Fat Content and Resistive Index in Male Rats with High-Fat DietPrasetyo Sarwono Putro, Dono Indarto, Bambang Purwanto, Widyastuti Soewondo, Sulistyani Kusumaningrum, and Khim Yatul Nguzum Prasetyo Sarwono Putro1,2, Dono Indarto1,3,4,*, Bambang Purwanto1,5, Widyastuti Soewondo2, Sulistyani Kusumaningrum1,2, Khim Yatul Nguzum4 1Doctorate Program of Medical Sciences, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA. 2Department of Radiology, Dr. Moewardi General Hospital/Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA. 3Department of Physiology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA. 4Biomedical Laboratory, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA. 5Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, INDONESIA. Abstract:Introduction: Dictamine is found in the Toddalia aculeata plant and is able to interact with Flavin- Containing Monooxygenase-3 (FMO3) in silico, which mediates endogenous atherosclerosis formation. Therefore, this study aimed to investigate the effects of T. aculeata extract (TAE) administration on Body Weight (BW), Body Mass Index (BMI), Body Fat Content (BFC), and Resistive Index (RI) in rats with a high-fat diet. Methods: Forty male Sprague-Dawley rats were randomly divided into the negative control (NC), positive control (PC) + 2.98 μg/kg BW dictamine and treatment (TAE1-3) + 200, 400, and 800 mg/ kg BW TAE respectively. All rats were given a high-fat diet (HFD) for 28 days. The data were analyzed statistically using one-way ANOVA, repeated-measured ANOVA, and Friedman’s tests with p<0.05. Results: The average of rats’ BW in TAE2 (270±13.78 g) and TAE3 (276.62±40.31 g) was lower than that of the NC (304.12± 4.16 g) but only the TAE2 group was significantly different (p=0.032). Rats in the TAE 1-3 groups had the average BMI (26.03±5.61; 21.84±0.81; 20.78±2.17 g/cm3) significantly lower than the NC (29.61±2.28 g/cm3) and the PC (28.67±1.68 g/cm3) for TAE2 and 3. The same pattern was also observed in BFC. All treatment groups had significantly lower RI compared to the NC group (0.62±0.07 cm). Conclusion: Administration of 400 and 800 mg/kg BW TAE for 28 days decreases BW, BMI, BFC, and RI in rats with a high-fat diet. Dictamine in the ethanol extract of T. aculeata leaves might contribute to the reduction of RI in rats with a high-fat diet. Keywords:Body Fat Content, Body Mass Index, Obesity, Resistive Index, Toddalia Aculeata Extract.View:PDF (1.06 MB) PDF Images BMI changes in 5 rats’ groups with or without TAE administrations. ( ‹ Risk Factors of Acute and Chronic Erythema Nodosum Leprosum in Dr. Soetomo General Academic Hospital Surabaya up Increased Risk of Tumor Necrosis Factor-Alpha Levels in Adult Patients with Malignancy Receiving Non-Leucodepleted Packed Red Cells Transfusion ›