ArticleViewAbstractPharmacognosy Journal,2022,14,6,806-812.DOI:10.5530/pj.2022.14.171Published:December 2022Type:Research Article In Silico Study of the Potential of Endemic Sumatra Wild Turmeric Rhizomes (Curcuma Sumatrana: Zingiberaceae) As Anti-CancerAldi Tamara Rahman, Rafia, Aiken Jethro, Putra Santoso, Viol Dhea Kharisma, Ahmad Affan Ali Murtadlo, Devi Purnamasari, Nunuk Hariani Soekamto, ANM Ansori, Kuswati, Riso Sari Mandeli, Kawther Ameen Muhammed Saeed Aledresi, Nur Farhana Mohd Yusof, Vikash Jakhmola, Maksim Rebezov, Maksim Rebezov, Rahadian Zainul, Kiran Dobhal, Tarun Parashar, Muhammad Arya Ghifari, and Deffi Ayu Puspito Sari Aldi Tamara Rahman1, Rafia1, Aiken Jethro2, Putra Santoso1, Viol Dhea Kharisma3,4, Ahmad Affan Ali Murtadlo4, Devi Purnamasari5, Nunuk Hariani Soekamto6, ANM Ansori7, Kuswati8, Riso Sari Mandeli9, Kawther Ameen Muhammed Saeed Aledresi10, Nur Farhana Mohd Yusof11, Vikash Jakhmola12, Maksim Rebezov13,14,15, Rahadian Zainul16,17,*, Kiran Dobhal12, Tarun Parashar12, Muhammad Arya Ghifari18, Deffi Ayu Puspito Sari19 1Department of Biology, Faculty of Mathematics and Natural Sciences, Andalas University, Padang, INDONESIA. 2Department of Medicine, Faculty of Medicine, Andalas University, Padang, INDONESIA. 3Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA. 4Division of Molecular Biology and Genetics, Generasi Biology Indonesia Foundation, Gresik, INDONESIA. 5Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, INDONESIA. 6Chemistry Department, Faculty of Mathematics and Natural Science, Hasanuddin University, INDONESIA. 7Professor Nidom Foundation, Surabaya, INDONESIA. 8Biology Education Study Program, Faculty of Teacher Training and Education, Jember University, INDONESIA. 9Environmental Science, Postgraduate Programme, Universitas Negeri Padang, Padang, INDONESIA. 10Biochemistry Department, Hawler Medical University, Erbil, Arbil Governorate, Iraqi Kurdistan, IRAQ. 11College of Engineering (Chemical), Universiti Teknologi MARA (UiTM), Jalan Purnama, Bandar Seri Alam, Masai, Johor, MALAYSIA. 12Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA. 13Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, RUSSIAN FEDERATION. 14Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIAN FEDERATION. 15Department of Scientific Research, Russian State Agrarian University, Moscow, RUSSIAN FEDERATION. 16Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMPBIOTICS), Universitas Negeri Padang, Padang, INDONESIA. 17Department of Chemistry, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, INDONESIA. 18Department of Informatics Engineering, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA 19Environmental Engineering Program Study, Faculty of Engineering and Computer Sciences, Universitas Bakrie, Jakarta, INDONESIA Abstract:Cancer is one of the diseases that is the highest cause of death in humans. Most human cancer cells are formed as a result of over-expression of anti-apoptotic proteins. Thus, the activation of these proteins can inhibit pro-apoptotic proteins, then apoptosis will be inhibited so that other apoptotic pathways need to be activated to prevent cancer cells from developing. Current cancer treatments, such as chemotherapy using synthetic compounds, have various side effects, so research on natural based therapies can be used as an alternative in cancer treatment. Curcuma sumatrana is one of the plants of the Zingiberaceae family which is an endemic plant from Sumatra which is found along the Bukit Barisan. The research was carried out in silico by analyzing the potential bioactivity of the compounds, testing the bioavailability, toxicity, and molecular docking of the bioactive compounds from the ethanol extract of the rhizome of C. sumatrana which had been previously identified through gas chromatography-mass spectroscopy (GCMS) analysis. The results obtained that the compound 9-Acetyl-S-octahydrophenanthrene and 3-Oxoandrosta- 1,4-dien-17.beta.-spiro-2'-3'-oxo-oxetanecontained in C. sumatrana has the potential to be developed as an anticancer where the compound has good bioavailability value and is not toxic and potentially can trigger apoptosis. However, the results of this study need to be analyzed further with an in vitro or in vivo approach. Keywords:Anticancer, C. sumatrana, in silicoView:PDF (1.26 MB) PDF Images Graphical Abstract ‹ The Potential of Antivirus Compounds in Gletang (Tridax procumbens Linn.) in Inhibiting 3CLpro Receptor of SARS-CoV-2 Virus by In Silico up Correlation of the Presence of Non Structural-1 (NS1) Antigen Dengue Virus with Severity of Dengue Infection ›