ArticleViewAbstractPharmacognosy Journal,2022,14,6s,1067-1074.DOI:10.5530/pj.2022.14.211Published:January 2023Type:Review ArticleThe Role of Breast Milk on Reducing the Risk of Neonatal Sepsis in Preterm and Low Birth Weight Infants: A Systematic Review and Meta-AnalysisTita Natalia Manurung, Citrawati Dyah Kencono Wungu, and Martono Tri Utomo Tita Natalia Manurung1, Citrawati Dyah Kencono Wungu2,*, Martono Tri Utomo1 1Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA. 2Departement of Biochemistry, Faculty of Medicine, Universitas Airlangga, Surabaya, INDONESIA. Abstract:Background: High mortality and morbidity rates are associated with neonatal sepsis in preterm and low birth weight infants. Aside from controlling the nosocomial infection, intervention for reducing the risk of sepsis is demanded. The best nutrition for preterm infants is breast milk. Bioactive compounds found in it, such as antibacterial, antiviral, and anti-inflammatory activities not only for immunity against the infection but also for growth, and development. Objective: To investigate the effect of breast milk against the risk of neonatal sepsis in preterm and low birth weight infants. Methods: We conducted an electronic search through several databases including PubMed, Web of Science, Science Direct, and Scopus. We performed an analysis on nutritional feeding and volume of breast milk and late-onset sepsis from ten potential observational studies. Results: Breast milk significantly reduced the risk of sepsis in preterm and low birth weight infants (pooled RR 0.70; 95 % CI 0.55 - 0.88, p = 0.002). In addition, when we performed subgroup analysis, we found that breast milk volume > 50ml/kgbw/day also reduce the risk of sepsis with pooled RR 0.61(95% CI 0.46-0.8, p=0.0004). Conclusion: Low birth weight and preterm infants had a lower risk of neonatal sepsis when they got breastmilk. To preserve the supply of breastmilk, health professionals should support and encourage mothers who were breastfeeding. Keywords:Breast milk, Low birth weight, Neonatal sepsis, Preterm infantView:PDF (413.18 KB) PDF Images Funnel plot of the effect of breast milk and preterm formula reducing the risk of neonatal sepsis. Figure 4: ‹ Effects of Pomegranate Extract Supplementation (Punica granatum L.) on Clinical Manifestations of Pulmonary Arterial Hypertension in Children with Acyanotic Congenital Heart Disease up Histopathological Perspectives of Multiple Organs in a Red- Footed Tortoise (Chelonoidis carbonaria) with Suspected Metabolic Bone Disease: A Case Report ›