The Role of CYP3A4 and CYP2C8 Polymorphism on Amiodarone Responses: Review Article

Introduction: Amiodarone is one of drug with narrow therapeutics index. This medicine was metabolized by CYP3A4 and CYP2C8. The changes in the activity of this enzymes by CYP3A4 and CYP2C8 polymorphism will affect the effect. The study aimed to determine the impact of CYP3A4 and CYP2C8 polymorphism on amiodarone responses. Method: the study is review article with search article in PubMed with keywords: ‘amiodarone’ and ‘polymorphism of CYP3A4’ and ‘polymorphism of CYP2C8’. Results: We collect 46 references to determine of impact polymorphism of CYP3A4 and CYP2C8 on amiodarone responses. Conclusion: Individual with CYP3A4*22 (rs35599367, 15389C>T); CYP2C8*2 (A805T), CYP2C8*3 (G416A, A1196G), and CYP2C8*4 (C792G) and CYP2C8*4 polymorphism have lower activity of CYP3A4 and CYP2C8 enzymes and potentially cause adverse effect.