ArticleViewAbstractPharmacognosy Journal,2023,15,4,575-580.DOI:10.5530/pj.2023.15.122Published:August 2023Type:Research ArticleIn Silico Study on the Inhibition of Sitogluside from Clove Plant (Syzygium aromaticum) on Interleukin 2 in B and T Cell ProliferationLinda Rosalina, Devi Purnamasari, Rismi Verawati, Okta Suryani, Muhammad Arya Ghifari, Amalia Putri Lubis, Rahadian Zainul, Riso Sari Mandeli, Viol Dhea Kharisma, Vikash Jakhmola, Maksim Rebezov, and ANM Ansori Linda Rosalina1, Devi Purnamasari2, Rismi Verawati3, Okta Suryani3, Muhammad Arya Ghifari4, Amalia Putri Lubis3, Rahadian Zainul3,*, Riso Sari Mandeli5, Viol Dhea Kharisma6,7, Vikash Jakhmola8, Maksim Rebezov9,10, ANM Ansori6,7,8 1Department of Makeup and Beauty, Faculty of Tourism and Hospitality, Universitas Negeri Padang, INDONESIA. 2Department of Radiology Engineering, Universitas Awalbros, Pekanbaru, INDONESIA. 3Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Padang, INDONESIA. 4Informatics Engineering, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA. 5Environmental and Policy Researcher, Environmental Science Program, Universitas Negeri Padang, INDONESIA. 6Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA. 7Generasi Biologi Indonesia Foundation, Gresik, INDONESIA. 8Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA. 9Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, RUSSIAN FEDERATION. 10Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIAN FEDERATION. Abstract:This research discusses an in-silico study of sitogluside found in the clove plant (Syzygium aromaticum) as a potential inhibitor of B and T cell proliferation through interaction with Interleukin-2. This study utilizes methods such as Swiss Target Prediction, Pymol, Pyrex, Protein Plus, and Lipinski's Rule to predict the biological activity and pharmacokinetic characteristics of sitogluside. From the docking simulation results, sitogluside exhibited strong interactions with interleukin-2 with RMSD values of 0, 1.637, and 2.299, and Binding Affinities of -5.7, -5.5, and -5.5, indicating its potential effectiveness as an inhibitor. In addition, sitogluside fulfills Lipinski's rule with a molecular mass of 520, 4 hydrogen bond donors and acceptors, a log P value of 2.3, and a molar reactivity of 133, indicating a high potential for good bioavailability in biological systems. These results suggest that sitogluside from the clove plant holds potential as a new therapy in inhibiting B and T cell proliferation, however further research is needed to validate these findings and explore its potential in clinical treatments. Keywords:Cell Proliferation, Interleukin-2, Molecular docking, Sitogluside, Syzygium.View:PDF (1.24 MB) PDF Images Graphical Abstract ‹ The Effectiveness of the Si-DBD Application in Increasing the Number of Households in Conducting Periodic Larvae Examination at the Health Center in Bantaeng Regency up Interaction of Cynaroside from Orthosiphon Aristatus Plant Extract on TNF Alpha as a Stimulant in Malaria and Asthma ›