The Activity of Pegagan Embun Extract (Hydrocotyle sibthorpioides Lam.) in Capsule Form to SGPT and SGOT Levels in Humans

Purpose: The study aimed to determine the activity of administering Hydrocotyle sibthorpioides Lam. extract in capsule dosage on SGPT and SGOT levels in humans. Methods: The participants involved 20 healthy volunteers aged 20-25 years who were divided into 2 groups with placebo as a comparison. The treatment groups were given capsules containing Hydrocotyle sibthorpioides Lam. extract at a dose of 67 mg. The other group administered a placebo containing lactose for 3 days. SGPT and SGOT levels were measured before and after consuming the test capsules. The examination of SGPT and SGOT levels was carried out using a 5010 v5+ photometer. Results: SGPT levels before the capsules were 28.79 U/L for the placebo and 28.59 U/L for the test preparation group. After administration of Hydrocotyle sibthorpioides Lam. extract capsules were 24.26 U/L and for placebo 32.86 U/L. At the same time, the measurement results of SGOT levels before being given the capsule were 17.37 U/L for the placebo and 17.71 U/L for the test preparation group. After administration of Hydrocotyle sibthorpioides Lam. extract capsules, it was 14.56 U/L and 18.52 U/L for placebo. The study results show that Hydrocotyle sibthorpioides Lam. extract significantly decreases SGPT and SGOT levels in humans (p<0.5). Conclusion: This result indicates that Hydrocotyle sibthorpioides Lam extract is relatively non-toxic and safe for public use as an immunostimulant herbal medicine.