ArticleViewAbstractPharmacognosy Journal,2024,16,6,1290-1296.DOI:10.5530/pj.2024.16.208Published:January 2025Type:Original ArticleExploring the Calming Potential of Peppermint: Anxiolytic Effects of Mentha piperita Essential Oil on State and Trait AnxietyPaul Alan Arkin Alvarado-García, Marilú Roxana Soto-Vásquez, Taniht Lisseth Cubas Romero, Santiago M. Benites, Anthony Derlis Auris-López, and Gerardo Manuel Del Pino-Aliaga Paul Alan Arkin Alvarado- García1, Marilú Roxana Soto- Vásquez2, Taniht Lisseth Cubas Romero1, Santiago M. Benites3, Anthony Derlis Auris-López1, Gerardo Manuel Del Pino- Aliaga1 1Escuela de Psicología. Universidad Autónoma del Perú. Lima, PERÚ. 2Facultad de Farmacia y Bioquímica. Universidad Nacional de Trujillo, Trujillo, PERÚ. 3Universidad Autónoma del Perú. Lima, PERÚ. Abstract:Introduction: This study aimed to evaluate the anxiolytic effect of Mentha piperita essential oil on state and trait anxiety. Methods: The essential oil was extracted by hydrodistillation, and its chemical composition was analyzed using Gas Chromatography-Mass Spectrometry (GC-MS). A total of 93 participants were divided into a control group (CG) and an experimental group (EG), with 47 participants in the EG receiving MPEO aromatherapy and 46 in the CG. Anxiety levels were measured using the State-Trait Anxiety Inventory (STAI) at pretest and posttest phases. Results: GC-MS analysis showed that menthol had the highest concentration (42.56%), followed by menthone (19.24%) and linalool (11.68%). Mixed model analysis revealed that group assignment (EG vs. CG) was a significant predictor of posttest state anxiety (F=16.508, p=0.001) and trait anxiety (F=9.091, p=0.003), independent of pretest scores, supporting the intervention’s effect on reducing anxiety. Posttest results showed a significant reduction in state anxiety in the EG compared to the CG (p=0.001) with a large effect size (r=0.508), while trait anxiety showed a moderate reduction (p=0.001, r=0.342). Conclusion: These findings suggest that Mentha piperita essential oil may effectively reduce state and trait anxiety, with a more pronounced impact on state anxiety. Keywords:Anxiety, Essential oil, Mentha piperita, State anxiety, Trait anxietyView:PDF (321.42 KB) PDF Images Flowchart of the study. ‹ The Consequences of Hypertension and Obesity on Coronary Heart Disease up Effect of Cacao Bean Extract as a Paracetamol Adjuvant on Pain Scale and Tumor Necrosis Factor-Alpha in Neuropathic Pain: An Animal Model Study ›