Hindering Effect of Resveratrol on Oxidative Changes and Na⁺K⁺-ATPase activity in Rat Hepatocytes Exposed to Prenatal stress

Introduction: The fetal programming hypothesis states that conditions during pregnancy, including stress, will have long-term effects on adult health, probably via epigenetic mechanisms. Methodology: Pregnant rats were subjected to restrain stress either during early or late pregnancy with and without resveratrol. Blood and liver tissues were collected from 40 days old offsprings of the above rats to study the prenatal effect on corticosterone, and stress development. Results: It was found that levels of corticosterone advanced protein and lipid oxidation products, GSHRx, increase significantly in offsprings of stressed rats and decreased on intervention with resveratrol, whereas total antioxidants, vitamin C, GSH, SOD and Na+K+- ATPase decreased with stress and increase on resveratrol intervention as compared to controls. Conclusion: The alterations may be due to the effect of stress on HPA axis. Results also support the prevention/protective effect of resveratrol on oxidative stress and may be used as a measure to prevent the metabolic changes in adult life due to prenatal stress.