Antihyperlipidemic Activity of Murraya koenigii Leaves Methanolic and Aqueous Extracts on Serum Lipid Profile of High Fat-Fructose Fed Rats

Background: Dyslipidemia has been considered as one of coronary risk factors contributing to the cardiovascular diseases. The beneficial effects of Murraya koenigii leaf on HFFD induced hyperlipidemia in rats has been very less reported in the recent review of literature. Aim and Objectives: To study the hypolipidemic activity of Murraya koenigii leaves on the serum lipid profile in HFFD rat model. Material and Methods: Thirty-six rats of either sex were randomly divided into six groups of six animals each. HFFD was fed p.o to all rats from Groups I, II, IV, V and VI except Group III throughout the period of 14 weeks. Group III rats received normal diet and water ad libitum only. Group I, II, IV and V were treated respectively with AEMK (200 mg/kg/day, p. o), MEMK (200 mg/kg/day, p. o), MET (50 mg/kg/day, p. o) and ATO (10 mg/kg/day, p. o). On the last day of experimental study, blood was collected by retro-orbital puncture method. BSL and lipid profile were assessed. Results: Elevated levels of TC, TG, LDL-C, VLDL-C and diminished level of HDL-C were observed in group VI. Murraya koenigii leaves extract exhibited significant hypolipidemic effect on serum TC and LDL-C in rats owing to its hypocholesterolemic properties. AIP was highly significant in both of AEMK and MEMK extracts. Conclusion: Results of the present study have suggested that the antihyperlipidemic activity of Murraya koenigii leaves leading to decrease in serum lipid parameters mainly TC, LDL-C along with atherogenic risk might be due to its presence of bioactive compounds.