Effect of Porana paniculata Whole Plant on Blood Glucose Levels and Lipid Profile of STZ Induced Diabetic Rats

Background: To establish the antidiabetic potential of Porana paniculata whole plant belongs to Convolvulaceae family. Methods: Extraction and preliminary phytochemical screening were conducted by standard methods. Antidiabetic activity was evaluated by streptozotocin induced diabetic rats where the hydroalcoholic extract of plant was administered orally at a dose of 250 and 500 mg/kg for 30 days. Blood glucose levels were estimated at 1^st, 10^th, 20^th and 30^th day of study. Lipid profile was studied 30^th day of study and body weight of the animals was measured at day 1 and 30. Results: Plant extract significantly (p<0.01) reduced the blood glucose levels at both the tested dose levels of 250 and 500 mg/kg. The lipid profile was estimated in which the plant extract showed significant improved in both tested dose level that is 250 and 500 mg/kg. The body weight of the animals under study was also estimated on day 1 and 30 in which a good control was observed by the plant extract. Conclusion: Antidiabetic activity of Porana paniculata whole plant extract may be due to the presence of various phytoconstituents. Present study gives a scientific evidence for the folklore claim of the plant under study for its use in diabetes.