The Effect Hypoglycemic of Ethanol Extract Combination Red Betel Leaf (Piper crocatum) and Dayak Onion (Eleutherine palmifolia Merr) in Streptozotocin-Induced

Background: Red betel leaf and Dayak onion is used traditionally to treat diabetes mellitus, The use of this combination of extracts to assess the effectiveness of the combination therapy is getting better by working synergistically. Objective: This study aimed to determine the hypoglycemic effect and the effective dose of ethanol extract combination of red betel leaf and Dayak onion of male rats (Rattus norvegicus). Methods: The number of 35 male rats were divided into 7 groups and each group consisted of five rats. The first group (normal control) was given Na CMC; the second group (negative control) streptozotocin-induced ; the third group (positive control) glibenclamide , while the 4^th, 5^th,6^th, and 7^th were successively given a single dose of ethanol extract of red betel leaf 25 mg/KgBB, a single dose of Dayak onion50 mg/ KgBB, combination red betel leaf and forest onion bulbs, 25+50 and 50+100 mg/kg bb. Each rat group was intraperitoneally (IP) induced with STZ 40 mg/KgBB and then treated for 21 days. The hypoglycemic effect was tested by using the God- Pap method. Result: Phytochemical analysis revealed that flavonoids, tannins, saponins, phytosterols and phenols were present in ethanol extract of red betel leaf and forest onion bulbs. The study concluded that the combination of red betel leaf and Dayak onion at doses 25 mg/KgBB and 50 mg/KgBB were synergistic in reducing glucose. Conclusion: In conclusion, the ethanol extract combination of red betel leaf and dayak onion have hypoglycemic effects.