ArticleViewAbstractPharmacognosy Journal,2024,16,5,1029-1035.DOI:10.5530/pj.2024.16.166Published:October 2024Type:Original ArticleInfluence of Chamomile Leaves extract in Different Doses on Renal Functions and Diabetic indices in Streptozotocin – Induced Diabetic RatMohamed Zaeim Hafez Ahmed, Muhammad Abdelbaeth Hassan Elfiky, Elsayed Elagamy Elsayed Mohamed, Ramadan Hassan Ibrahim Thabet, Ahmed Mohamed Gad Allah, Ahmed Abdrabo Elshenawy Elsisi, Ahmed Abdel Nasser Ahmed Mohamed, Tarek Shikhon, Mostafa Abo-akrab, Sayed A.M.Mahmoud, Mohamed AbdelAziz Doma, Wael Ahmed Mahmoud Khattab, Khaled Saleh Ali Elhamaky, Mohamed El- Salamoni, Fatma Mahmoud Abdelraheem, Mahmoud Ahmad Mohamed Azab, Mahmoud Ahmad Mohamed Azab6, Mohamed E EL-Refaey, Ahmed A. Abd El-Rhman, Ahmed F. Abdel Ghany, and Ghada Adel Hegazy Mohamed Zaeim Hafez Ahmed1*, Muhammad Abdelbaeth Hassan Elfiky1, Elsayed Elagamy Elsayed Mohamed2, Ramadan Hassan Ibrahim Thabet2, Ahmed Mohamed Gad Allah3, Ahmed Abdrabo Elshenawy Elsisi2, Ahmed Abdel Nasser Ahmed Mohamed2, Tarek Shikhon4, Mostafa Abo-akrab4, Sayed A.M.Mahmoud5, Mohamed AbdelAziz Doma5, Wael Ahmed Mahmoud Khattab6, Khaled Saleh Ali Elhamaky7, Mohamed El-Salamoni6, Fatma Mahmoud Abdelraheem8, Mahmoud Ahmad Mohamed Azab6, Ashraf Abdel Aty Elshenawy Emara6, Mohamed E EL-Refaey1, Ahmed A. Abd El-Rhman1, Ahmed F. Abdel Ghany1, Ghada Adel Faculty of Medicine, Al-Azhar University (Assiut), Assiut, EGYPT. Abstract:Background: The prevalence of diabetes among Egyptians is rising. Therefore, there is always a demand for innovative natural medicines. Medicinal plants have long been a significant source in search of novel, effective alternatives for human therapy. Chamomile is one of the most widely used medicinal plants, which may help hyperglycemic patients by lowering blood sugar levels. Objectives: To determine how chamomile extract affects the kidneys when albino male rats with chronic diabetes are induced by streptozotocin (STZ). Methods: The study was conducted in the Al-Azhar Faculty of Medicine (Assiut) pharmacology department animal laboratory. For this investigation, a local strain of fifty adult male albino rats was used as the animal model and weighed 120 to 150 g. In this study, rats were divided into five groups, body weight, and systolic blood pressure was measured, and blood samples were collected for measuring blood glucose and insulin level, HbA1c, Na, K, and renal function tests, and histopathological examination was done. Results: After the study, mean glucose levels, HbA1c, urea, creatinine, K, and systolic blood pressure were significantly decreased in group IV & group V compared to group III. In contrast, body weight serum insulin level and Na increased dramatically in group IV & group V compared to group III. Conclusion: The serum levels of urea and creatinine in diabetic patients may be positively affected by chamomile. Additionally, short-term chamomile uses benefits diabetic individuals by decreasing loss of body weight, lowering HbA1c, and increasing insulin levels. Keywords:Chamomile leaves, Diabetes mellitus, StreptozotocinView:PharmacognJ-16-5-1029.pdf (995.24 KB) PDF Images Pancreas of normal rats that received distilled water (GI) (H & E stain x 400). Figure 1b. Pancreas of normal rats that received chamomile extract (150 mg/kg) (GII) (H & E stain x 400). Figure 1c. Pancreas of diabetic rats received distilled water (GIII) (H & E stain x 400) Figure 1d. Pancreas of diabetic rats that received chamomile extract (150 mg/kg) (GIV) (H & E stain x 400). Figure 1e. Pancreas of diabetic rats that received chamomile extract (300 mg/kg) (GV) (H & E stain x 400). Figure 1f. Kidney of normal rats that received distilled water (GI) (H & E stain x 400). Figure 1g. Kidney of normal rats that received chamomile extract (150 mg/kg) (GII) (H & E stain x 400). Figure 1h. Kidney of diabetic rats received distilled water (GIII) (H & E stain x 400). Figure 1i. Kidney of diabetic rats that received chamomile extract (150 mg/kg) (GIV) (H & E stain x 400). Figure 1j. Kidney of diabetic rats that received chamomile extract (300 mg/kg) (GV) (H & E stain x 400). ‹ Berberine Mitigates Betel-Nut Induced Hepatocarcinogenesis, Enhances Chemosensitivity to Cisplatin and Reduces Cisplatin- Induced Nephrotoxicity in Mice Exposed to an Aqueous Extract of Betel Nut up Pharmacological insight into The Potential Efficacy of Some Halophytes in Alleviating Digestive System Disorders ›