ArticleViewAbstractPharmacognosy Journal,2020,12,1,25-28.DOI:10.5530/pj.2020.12.5Published:February 2020Type:Original ArticleSubacute Toxicity of Butanol Fraction of Tali Putri Plants (Cassytha filiformis L.) Against Hematology Parameters of White Male MiceDwisari Dillasamola, Annisa Yatursyi, and Armenia Dwisari Dillasamola1, Annisa Yatursyi1, Armenia1,* 1Unit of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Andalas University, Padang, INDONESIA. Abstract:Hematotoxicity study of butanol fraction of Cassytha filiformis L. on white male mice has been performed. A total of 12 white male mice were used, and they were divided into four groups. Each group consists of 3 mice. These animals were treated with Cassytha filiformis L. butanolic fraction at several doses of 2.5, 5, and 10 mg/kg for seven days. Hemoglobin value, erythrocytes, platelets, leukocytes, monocytes, lymphocytes, eosinophils, neutrophils, and basophils counts were measured at the 1st, 3rd, and 7th day of treatment. The data of this study were analyzed using two-way ANOVA, followed by Duncan's multiple region tests. The results showed that the doses of butanol fraction did not affect hemoglobin value, erythrocytes, leukocytes, and neutrophils (p >0.1), but it significantly reduced platelet, monocyte, lymphocyte count, and increases eosinophils (p <0.01) counts within their normal limits. There is no influence on the duration of administration and the interaction of dosage, and also the duration of use of the parameters above. This result implies that the Cassytha filiformis butanol fraction at doses of 2.5-10 mg/kg does not affect hematology parameters if it were used for seven days. Keywords:Butanol fraction, Cassytha filiformis L, Haematology, Subacute toxicityView:PDF (1.38 MB) PDF Images Hematological features of mice ‹ Cytotoxicity of Soursop Leaves (Annona muricata) against Cervical HeLa Cancer Cells up Anticancer Activity of Ruellia britoniana Flower on Cervical HeLa Cancer Cells ›