ArticleViewAbstractPharmacognosy Journal,2022,14,6,702-709.DOI:10.5530/pj.2022.14.157Published:December 2022Type:Original ArticleInfluence of Chitosan Concentration on Characteristic of Microspheres Delivery System Prepared from Eleutherine palmifolia (L.) Merr. ExtractRoihatul Mutiah, Wirda Ardania, Arief Suryadinata, Dewi Sinta Megawati, Anik Listiyana, Abdul Wafi, and Rahmi Annisa Roihatul Mutiah1, Wirda Ardania2, Arief Suryadinata3, Dewi Sinta Megawati4, Anik Listiyana5, Abdul Wafi6, Rahmi Annisa7,* 1Department of Pharmacy, Faculty of Medicine and Health Science, Maulana Malik Ibrahim State Islamic UniversityMalang, Malang, INDONESİA. 2Department of Pharmacy, Faculty of Medicine and Health Science, Maulana Malik Ibrahim State Islamic University Malang, Malang, INDONESİA. 3Department of Pharmacy, Faculty of Medicine and Health Science, Maulana Malik Ibrahim State Islamic University Malang, Malang, INDONESİA. 4Department of Pharmacy, Faculty of Medicine and Health Science, Maulana Malik Ibrahim State Islamic University Malang, Malang, INDONESİA. 5Department of Medical Education, Faculty of Medical and Health Sciences, Maulana Malik Ibrahim State Islamic University Malang, Malang, INDONESİA. 6Department of Pharmacy, Faculty of Medicine and Health Science, Maulana Malik Ibrahim State Islamic University Malang, Malang, INDONESİA. 7Department of Pharmacy, Faculty of Medicine and Health Science, Maulana Malik Ibrahim State Islamic University Malang, Malang, INDONESİA. Abstract:Background: Eleutherine palmifolia (L.) Merr. (E.palmifolia) is a medicinal plant containing naphthoquinone, isoliquiritigenin, and oxyresveratrol compound. This study aims to formulate and characterize the E. palmifolia microspheres delivery system using chitosan variation as the polymer. Methods: The preparation method was the solvent evaporation method. The microspheres delivery system was performed by variation of chitosan concentration in each formulation 0.637% (F1), 1.275% (F2), and 1.912% (F3). The physical and chemical characterizations include Entrapment Efficiency (EE), yield percentage, particle size, particle morphology, FTIR analysis, X-Ray Diffraction (XRD) analysis, and Differential Thermal Analysis (DTA) had been evaluated. Results: The results showed that chitosan concentration variation affected the microsphere's physical and chemical characteristics. Variations in the concentration of chitosan polymer (0.637%, 1.275% and 1.912%) had an effect on the physical characteristics of the microspheres of the resulting Dayak onion bulb extract. The higher the concentration of chitosan used, the higher the entrapment efficiency and the yield yield will increase. Meanwhile, in observing the particle size, the higher the concentration of chitosan used, the smaller the particle size produced. The optimal concentration of chitosan as a polymer at concentration variations of 0.637%, 1.275% and 1.912% to provide good physical characteristics of the Dayak onion bulb extract microspheres was shown in formula 3 with a chitosan concentration of 1.912%. Conclusion: The better characteristic was obtained upon higher chitosan concentration. The best physical characteristics of E.palmifolia extract microspheres were obtained from chitosan concentration at 1.912% (F3). Keywords:Characteristic, Chitosan, Delivery system., Eleutherine palmifolia, MicrospheresView:PDF (778.14 KB) PDF Images X-Ray Diffraction Spectra of Chitosan ‹ The Interactive Antimicrobial Activities of Selected South African Terminalia spp. Extracts in Combination with Conventional Antibiotics against Gastrointestinal Pathogens up Effects of Acalypha indica L. Extract on Inflammatory Response in The Pathogenesis of Nonalcoholic Fatty Liver Disease: An Overview of TLR9, NFκB and TNFα Expression in Hepatocytes and Macrophages of Sprague-Dawley Rats ›