ArticleViewAbstractPharmacognosy Journal,2024,16,3,689-694.DOI:10.5530/pj.2024.16.110Published:June 2024Type:Research ArticleBiomarker Profiles Associated with Covid-19 Mortality in East Java, Indonesia: A Tertiary Care Hospital StudyRetno Budiarti, Ediono, Muhammad Miftahussurur, Abdulloh Machin, Mochammad Wijdan Rosyich, Ayu Imamatun Nisa, Fatimatuzzahro, Nila Novia Putri, and Muhammad Ja’far Shodiq Retno Budiarti1*, Ediono2, Muhammad Miftahussurur3,4, Abdulloh Machin5,7, Wiwin Is Effendi5,6, Mochammad Wijdan Rosyich7, Ayu Imamatun Nisa’8, Fatimatuzzahro’8, Nila Novia Putri7, Muhammad Ja’far Shodiq7 1Department of Microbiology, Faculty of Medicine, Hang Tuah University, Surabaya, INDONESIA. 2Pulmonology Department, Naval Hospital, RSAL Dr. Ramelan, Surabaya, INDONESIA. 3Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine / Dr. Soetomo Teaching Hospital, Airlangga University, Surabaya, INDONESIA. 4Helicobacter Pylori and Microbiota Study Group, Institute of Tropical Disease, Airlangga University, Surabaya, INDONESIA. 5Infectious Hospital, Airlangga University, Surabaya, INDONESIA. 6Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Airlangga University, Surabaya 7Neurology Department, Faculty of Medicine / Dr. Soetomo Teaching Hospital, Airlangga University, Surabaya, INDONESIA. 8Faculty of Medicine, Airlangga University, Surabaya, INDONESIA. Abstract:Objective: This study aimed to compare the most useful biomarkers for predicting prognosis and response to therapy in COVID-19 patients. Material and Methods: This quantitative study involved 639 patients who were hospitalized with COVID-19 infection. Patients without any biochemical marker result; patients referred to another hospital; and peripheral oxygen levels measured using oxygen supplementation were excluded from the study. Results: There was a statistically significant difference in terms of demographics, vital signs on admission, and laboratory parameters. The risk of mortality in COVID-19 is significantly influenced by c-reactive protein (CRP) and interleukin-6 (IL-6) levels (p-value <0.05). Conclusion: Findings revealed these biomarkers could help the future development of more personalized treatment and diagnostic approaches. Keywords:Biomarker, COVID-19, OutcomeView:PDF (299.24 KB) PDF Images ROC curve analysis of biochemical markers in predicting mortality in COVID-19 infection. ‹ Mechanism and Antifungal Activities Vulvovaginal Candidiasis Isolated from Patients Against Ethanol Extracts of Parameria laevigata (Juss.) Moldenke Stem Bark up The Relationship Between Blood Levels of Ubiquitin Carboxyterminal Hydrolase L1 (UCH-L1) Protein and the Severity of Traumatic Brain Injury Based on the Glasgow Coma Scale and Rotterdam CT Score ›