ArticleViewAbstractPharmacognosy Journal,2021,13,5,1072-1078.DOI:10.5530/pj.2021.13.139Published:September 2021Type:Original ArticleTotal Phenol Content and Gastric Anti-Ulcer Activity of Hydroalcoholic Extract of Persea caerulea (Ruiz & Pav.) Mez. BarkAbhel A. Calderón-Peña, Cinthya L. Aspajo-Villalaz, Carmen R. Silva-Correa, Víctor E. Villarreal-La Torre, María V González-Blas, Orlando E Pretel-Sevillano, Marco L Salazar-Castillo, Maricielo Vaella-Alarcón, Franco Huaccha-Cáceres, Jonatam León-Soto, Whendy Alaya-Davirán, Anabel D. González-Siccha, William Antonio Sagástegui-Guarniz, Luz M. Guerrero-Espino, and Julio Hilario-Vargas Abhel A. Calderón-Peña1,*, Cinthya L. Aspajo-Villalaz1, Carmen R. Silva-Correa2, Víctor E. Villarreal-La Torre2, María V. González-Blas2, Orlando E. Pretel-Sevillano1, Marco L. Salazar-Castillo1, Maricielo Vaella-Alarcón1, Franco Huaccha- Cáceres1, Jonatam León-Soto1, Whendy Alaya-Davirán1, Anabel D. González-Siccha2, William Antonio Sagástegui-Guarniz2, Luz M. Guerrero-Espino3, Julio Hilario-Vargas3 1Facultad de Ciencias Biológicas, Universidad Nacional de Trujillo, PERÚ. 2Facultad de Farmacia y Bioquímica, Universidad Nacional de Trujillo, PERÚ. 3Facultad de Medicina, Universidad Nacional de Trujillo, PERÚ. Abstract:Objective: Determine the content of total phenols and evaluate the gastroprotective effect of the extract of Persea caerulea (Ruiz & Pav.) Mez. in mice with induced gastric ulcer. Material and Methods: The bark of Persea caerulea was macerated in 70% ethanol and the phenol content was determined using the Folin-Ciocalteu method. The female Mus musculus Balb/c specimens were distributed in the following groups: White Control Group, without indomethacin dosing; Negative Control Group, dosing with indomethacin; Positive Control Group treated with ranitidine at a dose of 50 mg/kg; Groups P. caerulea treated with extract at doses of 50 mg/kg, 100 mg/kg and 200 mg/kg. Gastric ulcer was induced with indomethacin orally at a dose of 50 mg/kg, the procedure was repeated 12 hours later; Gastroprotective treatment was administered 60 minutes after each dose of indomethacin, 6 hours after the last dose, sodium pentobarbital was euthanized and the stomach was resected to determine ulceration using the Marhuenda Scale. Results: Higher percentages of gastric ulcer inhibition were obtained in the P. caerulea 100 mg/kg (80%) and P. caerulea 200 mg/kg (85.71%) groups. Conclusions: Extract of Persea caerulea (Ruiz & Pav.) Mez., At doses of 100 and 200 mg/kg of body weight, has a gastric antiulcerative effect which is related to its content of total polyphenols. Keywords:Gastric ulcer, Indomethacin, MiceView:PDF (4.46 MB) PDF Images Graphical Abstract ‹ Chitosan-Tripolyphosphate Nanoparticles of Mango Ginger (Curcuma mangga) Extract: Phytochemical Screening, Formulation, Characterization, and Antioxidant Activity up Anti-diabetic Activity of the Red Dragon Fruit Peel (Hylocereus polyrhizus) in Ethanol Extract against Diabetic Rats ›