ArticleViewAbstractPharmacognosy Journal,2022,14,6,813-816.DOI:10.5530/pj.2022.14.172Published:December 2022Type:Research Article Correlation of the Presence of Non Structural-1 (NS1) Antigen Dengue Virus with Severity of Dengue InfectionIchwan Baihaki, Beti Ernawati Dewi, Viol Dhea Kharisma, Ahmad Affan Ali Murtadlo, Muhammad Badrut Tamam, Devi Purnamasari, Nunuk Hariani Soekamto, ANM Ansori, Kuswati, Riso Sari Mandeli, Kawther Ameen Muhammed Saeed Aledresi, Nur Farhana Mohd Yusof, Vikash Jakhmola, Maksim Rebezov, Pavel Burkov, Marina Derkho, Pavel Scherbakov, Rahadian Zainul, Muhammad Raffi Ghifari, Asmi Citra Malina AR Tasakka, and Tengku Siti Hajar Haryuna Ichwan Baihaki1, Beti Ernawati Dewi2,3, Viol Dhea Kharisma4,5, Ahmad Affan Ali Murtadlo5, Muhammad Badrut Tamam6, Devi Purnamasari7, Nunuk Hariani Soekamto8, ANM Ansori9, Kuswati10, Riso Sari Mandeli11, Kawther Ameen Muhammed Saeed Aledresi12, Nur Farhana Mohd Yusof13, Vikash Jakhmola14, Maksim Rebezov15,16,17, Pavel Burkov18, Marina Derkho18, Pavel Scherbakov18, Rahadian Zainul19,20,*, Muhammad Raffi Ghifari21, Asmi Citra Malina AR Tasakka22, Tengku Siti Hajar Haryuna23 1Master Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, INDONESIA. 2Department of Microbiology, Faculty of Medicine, Universitas Indonesia-RSUPN Cipto Mangunkusumo, Jakarta, INDONESIA. 3Infectious Disease and Immunology Cluster, Indonesian Medical Education and Research Institute, Jakarta, INDONESIA. 4Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, INDONESIA. 5Division of Molecular Biology and Genetics, Generasi Biologi Indonesia Foundation, Gresik, INDONESIA. 6Department of Biology, Faculty of Sciences and Technology, Universitas Muhammadiyah Lamongan, Lamongan, INDONESIA. 7Department of Radiology Engineering, Universitas Awal Bros, Pekanbaru, INDONESIA. 8Chemistry Department, Faculty of Mathematics and Natural Science, Hasanuddin University, INDONESIA. 9Professor Nidom Foundation, Surabaya, INDONESIA. 10Biology Education Study Program, Faculty of Teacher Training and Education, Jember University, INDONESIA. 11Environmental Science, Postgraduate Programme, Universitas Negeri Padang, Padang, INDONESIA. 12Biochemistry Department, Hawler Medical University, Erbil, Arbil Governorate, Iraqi Kurdistan, IRAQ. 13College of Engineering (Chemical), Universiti Teknologi MARA (UiTM), Jalan Purnama, Bandar Seri Alam, Masai, Johor, MALAYSIA. 14Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, INDIA. 15Department of Scientific Research, V. M. Gorbatov Federal Research Center for Food Systems, Moscow, RUSSIAN FEDERATION. 16Faculty of Biotechnology and Food Engineering, Ural State Agrarian University, Yekaterinburg, RUSSIAN FEDERATION. 17Department of Scientific Research, Russian State Agrarian University, Moscow, RUSSIAN FEDERATION. 18Institute of Veterinary Medicine, South Ural State Agrarian University, Troitsk, RUSSIAN FEDERATION. 19Center for Advanced Material Processing, Artificial Intelligence, and Biophysic Informatics (CAMP-BIOTICS), Universitas Negeri Padang, Padang, INDONESIA. 20Department of Chemistry, Faculty of Mathematics and Natural Sciences Universitas Negeri Padang, Padang, INDONESIA. 21Department of Informatics Engineering, Faculty of Computer Sciences, Universitas Brawijaya, Malang, INDONESIA 22Faculty of Marine Science and Fisheries, Universitas Hasanuddin, Makassar, INDONESIA 23Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, INDONESIA Abstract:Dengue is a major public health threat worldwide, affecting approximately 3 billion people. More than 100 countries in the world located in tropical and subtropical areas, there are at least 100 to 400 million people infected with the dengue virus which causes dengue hemorrhagic fever (DHF). Soluble Non Structural Protein (sNS1) DENV is a soluble NS1 protein that is secreted and found in the serum of patients during acute infection. Because of its presence early in infection, sNS1 is used as a diagnostic indicator of acute dengue infection. NS1 can directly activate platelets through TLR4 and can further increase platelet aggregation, endothelial cell adhesion, and phagocytosis by macrophages that can cause thrombocytopenia so that high sNS1 levels are associated with disease severity. From the results of the study showed p <0.05. This indicates that there is a correlation between the presence of NS1 and the severity of dengue infection. Keywords:Dengue virus, NS1 antigen, ThrombocytopeniaView:PDF (439.66 KB) PDF Images Graphical Abstract ‹ In Silico Study of the Potential of Endemic Sumatra Wild Turmeric Rhizomes (Curcuma Sumatrana: Zingiberaceae) As Anti-Cancer up An In Silico Study to Explore the Role of EGFR in Ovarian Cancer ›